Gene/Proteome Database (LMPD)

LMPD ID
LMP001687
Gene ID
14739
Species
Mus musculus (Mouse)
Gene Name
sphingosine-1-phosphate receptor 2
Gene Symbol
S1pr2
Synonyms
1100001A16Rik; Edg5; Gpcr13; H218; LPb2; S1P2
Alternate Names
sphingosine 1-phosphate receptor 2; S1P receptor 2; S1P receptor Edg-5; lysophospholipid receptor B2; G-protein coupled receptor 13; sphingosine 1-phosphate receptor Edg-5; sphingosine-1-phosphate receptor S1P(2); endothelial differentiation G-protein coupled receptor 5; endothelial differentiation, sphingolipid G-protein-coupled receptor, 5
Chromosome
9
Map Location
9 A3|9 7.68 cM

Proteins

sphingosine 1-phosphate receptor 2
Refseq ID NP_034463
Protein GI 45433562
UniProt ID P52592
mRNA ID NM_010333
Length 352
RefSeq Status VALIDATED
MGGLYSEYLNPEKVLEHYNYTKETLDMQETTSRKVASAFIIILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGHVTLSLTPVQWFAREGSAFITLSASVFSLLAIAIERQVALAKVKLYGSDKSCRMLMLIGASWLISLILGGLPILGWNCLNQLEACSTVLPLYAKHYVLCVVTIFSVILLAIVALYVRIYFVVRSSHADVAGPQTLALLKTVTIVLGVFIICWLPAFSILLLDSTCPVRACPVLYKAHYFFAFATLNSLLNPVIYTWRSRDLRREVLRPLQCWRRGKGVTGRRGGNPGHRLLPLRSSSSLERGMHMPTSPTFLEGNTVV

Gene Information

Entrez Gene ID
14739
Gene Name
sphingosine-1-phosphate receptor 2
Gene Symbol
S1pr2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0038036 IEA:InterPro F sphingosine-1-phosphate receptor activity
GO:0090394 IMP:MGI P negative regulation of excitatory postsynaptic membrane potential

REACTOME Pathway Links

REACTOME Pathway ID Description
5893663 G alpha (i) signalling events
5893755 Lysosphingolipid and LPA receptors

Domain Information

InterPro Annotations

Accession Description
IPR004063 EDG-5 sphingosine 1-phosphate receptor
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
IPR004061 Sphingosine 1-phosphate receptor

UniProt Annotations

Entry Information

Gene Name
sphingosine-1-phosphate receptor 2
Protein Entry
S1PR2_MOUSE
UniProt ID
P52592
Species
Mouse

Comments

Comment Type Description
Function Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues.
Similarity Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Most abundant in heart and lung; low, but clearly observed in kidney, liver and thymus; much lower but detectable in brain, testis, stomach and intestine. Not significantly detected in any of the sections of embryonic day (E) 14-18, except in embryonic brain. {ECO:0000269|PubMed:9931453}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001687 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
45433562 RefSeq NP_034463 352 sphingosine 1-phosphate receptor 2

Identical Sequences to LMP001687 proteins

Reference Database Accession Length Protein Name
GI:45433562 DBBJ BAE30079.1 352 unnamed protein product [Mus musculus]
GI:45433562 DBBJ BAE35224.1 352 unnamed protein product [Mus musculus]
GI:45433562 DBBJ BAE41795.1 352 unnamed protein product [Mus musculus]
GI:45433562 GenBank EDL25146.1 352 endothelial differentiation, sphingolipid G-protein-coupled receptor, 5 [Mus musculus]
GI:45433562 RefSeq XP_006510082.1 352 PREDICTED: sphingosine 1-phosphate receptor 2 isoform X1 [Mus musculus]
GI:45433562 SwissProt P52592.3 352 RecName: Full=Sphingosine 1-phosphate receptor 2; Short=S1P receptor 2; Short=S1P2; AltName: Full=Endothelial differentiation G-protein coupled receptor 5; AltName: Full=Lysophospholipid receptor B2; AltName: Full=Sphingosine 1-phosphate receptor Edg-5; Short=S1P receptor Edg-5 [Mus musculus]

Related Sequences to LMP001687 proteins

Reference Database Accession Length Protein Name
GI:45433562 DBBJ BAE31960.1 352 unnamed protein product [Mus musculus]
GI:45433562 GenBank AAA19241.1 352 pH218 [Rattus norvegicus]
GI:45433562 GenBank AAB44805.1 352 Sequence 2 from patent US 5585476
GI:45433562 GenBank AAD16976.1 352 lysophospholipid receptor B2 [Mus musculus]
GI:45433562 GenBank AAP00841.1 352 Sequence 2 from patent US 6518414
GI:45433562 SwissProt P47752.1 352 RecName: Full=Sphingosine 1-phosphate receptor 2; Short=S1P receptor 2; Short=S1P2; AltName: Full=AGR16; AltName: Full=Endothelial differentiation G-protein coupled receptor 5; AltName: Full=G-protein coupled receptor H218; AltName: Full=Sphingosine 1-phosphate receptor Edg-5; Short=S1P receptor Edg-5 [Rattus norvegicus]