Gene/Proteome Database (LMPD)

LMPD ID
LMP001688
Gene ID
23986
Species
Mus musculus (Mouse)
Gene Name
enoyl-Coenzyme A delta isomerase 2
Gene Symbol
Eci2
Synonyms
Acbd2; Drs1; Hca88; Peci
Alternate Names
enoyl-CoA delta isomerase 2, mitochondrial; dodecenoyl-CoA isomerase; D3,D2-enoyl-CoA isomerase; delta(3),delta(2)-enoyl-CoA isomerase; peroxisomal 3,2-trans-enoyl-CoA isomerase; peroxisomal delta3, delta2-enoyl-Coenzyme A isomerase
Chromosome
13
Map Location
13|13 A4
EC Number
5.3.3.8

Proteins

enoyl-CoA delta isomerase 2, mitochondrial isoform a
Refseq ID NP_001103801
Protein GI 160333193
UniProt ID Q9WUR2
mRNA ID NM_001110331
Length 391
RefSeq Status VALIDATED
MAAVTWSRARCWCPSVLQVFRLQVAKLHLGRPTMRASQQDFENALNQVKLLKKDPGNEVKLRLYALYKQATEGPCNMPKPGMLDFVNKAKWDAWNALGSLPKETARQNYVDLVSSLSSSSEAPSQGKRGADEKARESKDILVTSEDGITKITFNRPTKKNAISFQMYRDIILALKNASTDNTVMAVFTGTGDYYCSGNDLTNFTSATGGIEEAASNGAVLLRDFVNSFIDFPKPLVAVVNGPAVGISVTLLGLFDAVFASDRATFHTPFSQLGQSPEACSSYTFPKMMGSAKAAEMLLFGKKLTAREAWAQGLVTEVFPESTFETEVWTRLKTYAKLPPNAMRISKELIRKNEKEKLYAVNAEECTTLQARWLSEECMNAIMSFVSRKPKL
enoyl-CoA delta isomerase 2, mitochondrial isoform b
Refseq ID NP_035998
Protein GI 160333195
UniProt ID Q9WUR2
mRNA ID NM_011868
Length 358
RefSeq Status VALIDATED
MRASQQDFENALNQVKLLKKDPGNEVKLRLYALYKQATEGPCNMPKPGMLDFVNKAKWDAWNALGSLPKETARQNYVDLVSSLSSSSEAPSQGKRGADEKARESKDILVTSEDGITKITFNRPTKKNAISFQMYRDIILALKNASTDNTVMAVFTGTGDYYCSGNDLTNFTSATGGIEEAASNGAVLLRDFVNSFIDFPKPLVAVVNGPAVGISVTLLGLFDAVFASDRATFHTPFSQLGQSPEACSSYTFPKMMGSAKAAEMLLFGKKLTAREAWAQGLVTEVFPESTFETEVWTRLKTYAKLPPNAMRISKELIRKNEKEKLYAVNAEECTTLQARWLSEECMNAIMSFVSRKPKL
transit_peptide: 1..36 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (Q9WUR2.2) calculated_mol_wt: 4141 peptide sequence: MAAVTWSRARCWCPSVLQVFRLQVAKLHLGRPTMRA mat_peptide: 37..391 product: Enoyl-CoA delta isomerase 2, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9WUR2.2) calculated_mol_wt: 39145 peptide sequence: SQQDFENALNQVKLLKKDPGNEVKLRLYALYKQATEGPCNMPKPGMLDFVNKAKWDAWNALGSLPKETARQNYVDLVSSLSSSSEAPSQGKRGADEKARESKDILVTSEDGITKITFNRPTKKNAISFQMYRDIILALKNASTDNTVMAVFTGTGDYYCSGNDLTNFTSATGGIEEAASNGAVLLRDFVNSFIDFPKPLVAVVNGPAVGISVTLLGLFDAVFASDRATFHTPFSQLGQSPEACSSYTFPKMMGSAKAAEMLLFGKKLTAREAWAQGLVTEVFPESTFETEVWTRLKTYAKLPPNAMRISKELIRKNEKEKLYAVNAEECTTLQARWLSEECMNAIMSFVSRKPKL

Gene Information

Entrez Gene ID
23986
Gene Name
enoyl-Coenzyme A delta isomerase 2
Gene Symbol
Eci2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IDA:MGI C mitochondrion
GO:0005782 ISS:UniProtKB C peroxisomal matrix
GO:0005777 IDA:HGNC C peroxisome
GO:0004165 IEA:UniProtKB-EC F dodecenoyl-CoA delta-isomerase activity
GO:0000062 IEA:InterPro F fatty-acyl-CoA binding
GO:0006635 IEA:Ensembl P fatty acid beta-oxidation
GO:0009062 ISS:UniProtKB P fatty acid catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu00071 Fatty acid degradation
ko04146 Peroxisome
mmu04146 Peroxisome

BIOCYC Pathway Links

BIOCYC Pathway ID Description
FAO-PWY fatty acid beta-oxidation I

Domain Information

InterPro Annotations

Accession Description
IPR000582 Acyl-CoA-binding protein, ACBP
IPR022408 Acyl-CoA-binding protein, ACBP, conserved site
IPR029045 ClpP/crotonase-like domain
IPR001753 Crotonase_core_superfam
IPR014352 FERM/acyl-CoA-binding protein, 3-helical bundle

UniProt Annotations

Entry Information

Gene Name
enoyl-Coenzyme A delta isomerase 2
Protein Entry
ECI2_MOUSE
UniProt ID
Q9WUR2
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9WUR2-1; Sequence=Displayed; Name=2; IsoId=Q9WUR2-2; Sequence=VSP_037855;
Catalytic Activity (3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl- CoA.
Function Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates (By similarity). {ECO:0000250}.
Ptm Acetylation of Lys-60 is observed in liver mitochondria from fasted mice but not from fed mice. {ECO:0000269|PubMed:23576753, ECO:0000269|PubMed:23806337}.
Sequence Caution Sequence=AAH01983.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Similarity Contains 1 ACB (acyl-CoA-binding) domain. {ECO:0000255|PROSITE-ProRule:PRU00573}.
Similarity In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. {ECO:0000305}.
Subcellular Location Isoform 1: Mitochondrion {ECO:0000250}.
Subcellular Location Isoform 2: Peroxisome matrix {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001688 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
160333193 RefSeq NP_001103801 391 enoyl-CoA delta isomerase 2, mitochondrial isoform a
160333195 RefSeq NP_035998 358 enoyl-CoA delta isomerase 2, mitochondrial isoform b

Identical Sequences to LMP001688 proteins

Reference Database Accession Length Protein Name
GI:160333195 RefSeq XP_006516736.1 358 PREDICTED: enoyl-CoA delta isomerase 2, mitochondrial isoform X1 [Mus musculus]
GI:160333195 RefSeq XP_006516737.1 358 PREDICTED: enoyl-CoA delta isomerase 2, mitochondrial isoform X2 [Mus musculus]
GI:160333195 RefSeq XP_006516738.1 358 PREDICTED: enoyl-CoA delta isomerase 2, mitochondrial isoform X3 [Mus musculus]
GI:160333195 RefSeq XP_006516739.1 358 PREDICTED: enoyl-CoA delta isomerase 2, mitochondrial isoform X4 [Mus musculus]
GI:160333195 RefSeq XP_006516740.1 358 PREDICTED: enoyl-CoA delta isomerase 2, mitochondrial isoform X5 [Mus musculus]
GI:160333193 SwissProt Q9WUR2.2 391 RecName: Full=Enoyl-CoA delta isomerase 2, mitochondrial; AltName: Full=Delta(3),delta(2)-enoyl-CoA isomerase; Short=D3,D2-enoyl-CoA isomerase; AltName: Full=Dodecenoyl-CoA isomerase; AltName: Full=Peroxisomal 3,2-trans-enoyl-CoA isomerase; Short=pECI; Flags: Precursor [Mus musculus]

Related Sequences to LMP001688 proteins

Reference Database Accession Length Protein Name
GI:160333193 DBBJ BAB26315.2 391 unnamed protein product [Mus musculus]
GI:160333195 DBBJ BAB26315.2 391 unnamed protein product [Mus musculus]
GI:160333193 DBBJ BAE42023.1 378 unnamed protein product [Mus musculus]
GI:160333195 DBBJ BAE42023.1 378 unnamed protein product [Mus musculus]
GI:160333195 GenBank EDL40901.1 358 mCG22255, isoform CRA_a [Mus musculus]
GI:160333195 GenBank EDL40902.1 358 mCG22255, isoform CRA_a [Mus musculus]
GI:160333195 RefSeq NP_001103801.1 391 enoyl-CoA delta isomerase 2, mitochondrial isoform a [Mus musculus]
GI:160333193 RefSeq XP_006516736.1 358 PREDICTED: enoyl-CoA delta isomerase 2, mitochondrial isoform X1 [Mus musculus]
GI:160333193 RefSeq XP_006516737.1 358 PREDICTED: enoyl-CoA delta isomerase 2, mitochondrial isoform X2 [Mus musculus]
GI:160333193 RefSeq XP_006516738.1 358 PREDICTED: enoyl-CoA delta isomerase 2, mitochondrial isoform X3 [Mus musculus]
GI:160333193 RefSeq XP_006516739.1 358 PREDICTED: enoyl-CoA delta isomerase 2, mitochondrial isoform X4 [Mus musculus]
GI:160333195 SwissProt Q9WUR2.2 391 RecName: Full=Enoyl-CoA delta isomerase 2, mitochondrial; AltName: Full=Delta(3),delta(2)-enoyl-CoA isomerase; Short=D3,D2-enoyl-CoA isomerase; AltName: Full=Dodecenoyl-CoA isomerase; AltName: Full=Peroxisomal 3,2-trans-enoyl-CoA isomerase; Short=pECI; Flags: Precursor [Mus musculus]