Gene/Proteome Database (LMPD)

LMPD ID
LMP001695
Gene ID
71949
Species
Mus musculus (Mouse)
Gene Name
ceramide synthase 5
Gene Symbol
Cers5
Synonyms
2310081H14Rik; AU045339; AW544927; Lass5; Trh4
Alternate Names
ceramide synthase 5; TRAM homolog 4; longevity assurance homolog 5; LAG1 homolog, ceramide synthase 5; LAG1 longevity assurance homolog 5; translocating chain-associating membrane protein homolog 4
Chromosome
15
Map Location
15 F1|15
EC Number
2.3.1.24

Proteins

ceramide synthase 5
Refseq ID NP_082291
Protein GI 21312638
UniProt ID Q9D6K9
mRNA ID NM_028015
Length 414
RefSeq Status PROVISIONAL
MATAAAETLGLLWGWLWSESFWLPQNVSWADLEGPGDGYGYPRAQHVLSVFPLAVCIFSVRMLFERFIAKPCALRVGIKDSPVNKVEPNDTLEKVFVSVTKYPDEKRLKGLSKQLDWSVRKIQCWFRHRRNQDKPPTLTKFCESMWRFTYYLCIFCYGIRFLWSMPWFWDTRQCWYNYPYQPLSRELYYYYITQLAFYWSLMFSQFIDVKRKDFLMMFIHHMIGIMLTTFSYVNNMVRVGALIFCLHDFADPLLEAAKMANYARRERLCTTLFVIFGAAFIVSRLAIFPLWILNTTLFESWEIIGPYPSWWLFNALLLILQVLHAIWSYLIVQTASKALSRGKVSKDDRSDVESSSEEEDETTHKNNLSGSSSSNGANCMNGYMGGSHLAEEQGTCKATGNLHFRASPHLHSCD

Gene Information

Entrez Gene ID
71949
Gene Name
ceramide synthase 5
Gene Symbol
Cers5
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:MGI C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0003677 IEA:UniProtKB-KW F DNA binding
GO:0050291 IDA:HGNC F sphingosine N-acyltransferase activity
GO:0046513 IDA:HGNC P ceramide biosynthetic process
GO:0030148 IDA:MGI P sphingolipid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu00600 Sphingolipid metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY3DJ-12 ceramide biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR016439 Longevity assurance, LAG1/LAC1
IPR006634 TRAM/LAG1/CLN8 homology domain

UniProt Annotations

Entry Information

Gene Name
ceramide synthase 5
Protein Entry
CERS5_MOUSE
UniProt ID
Q9D6K9
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D6K9-1; Sequence=Displayed; Name=2; IsoId=Q9D6K9-2; Sequence=VSP_011192, VSP_011193;
Catalytic Activity Acyl-CoA + sphingosine = CoA + N- acylsphingosine.
Function Dihydroceramide synthase. Catalyzes the acylation of sphingosine to form dihydroceramide, with high selectivity toward palmitoyl-CoA as acyl donor compared to stearoyl-CoA. Inhibited by fumonisin B1. {ECO:0000269|PubMed:12912983, ECO:0000269|PubMed:16100120}.
Pathway Lipid metabolism; sphingolipid metabolism.
Similarity Contains 1 TLC (TRAM/LAG1/CLN8) domain. {ECO:0000255|PROSITE-ProRule:PRU00205}.
Similarity Contains 1 homeobox DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00108}.
Subcellular Location Nucleus membrane {ECO:0000255|PROSITE- ProRule:PRU00108}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:12912983}; Multi-pass membrane protein {ECO:0000269|PubMed:12912983}.
Tissue Specificity Ubiquitously expressed, with highest levels in testis and kidney. {ECO:0000269|PubMed:12912983, ECO:0000269|PubMed:15823095}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001695 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
21312638 RefSeq NP_082291 414 ceramide synthase 5

Identical Sequences to LMP001695 proteins

Reference Database Accession Length Protein Name
GI:21312638 DBBJ BAE26527.1 414 unnamed protein product [Mus musculus]
GI:21312638 DBBJ BAE26634.1 414 unnamed protein product [Mus musculus]
GI:21312638 GenBank AAH46797.1 414 LAG1 homolog, ceramide synthase 5 [Mus musculus]
GI:21312638 GenBank EDL04112.1 414 longevity assurance homolog 5 (S. cerevisiae), isoform CRA_b [Mus musculus]
GI:21312638 GenBank AGF22452.1 414 Sequence 10 from patent US 8372595
GI:21312638 SwissProt Q9D6K9.1 414 RecName: Full=Ceramide synthase 5; Short=CerS5; AltName: Full=LAG1 longevity assurance homolog 5; AltName: Full=Translocating chain-associating membrane protein homolog 4; Short=TRAM homolog 4 [Mus musculus]

Related Sequences to LMP001695 proteins

Reference Database Accession Length Protein Name
GI:21312638 DBBJ BAC35894.1 414 unnamed protein product [Mus musculus]
GI:21312638 GenBank AAK40301.1 414 TRH4 [Mus musculus]
GI:21312638 GenBank EDL86968.1 413 longevity assurance homolog 5 (S. cerevisiae) (predicted), isoform CRA_b [Rattus norvegicus]
GI:21312638 GenBank AAI66794.1 413 Lass5 protein [Rattus norvegicus]
GI:21312638 RefSeq NP_001102463.1 449 ceramide synthase 5 [Rattus norvegicus]
GI:21312638 RefSeq XP_006257436.1 413 PREDICTED: ceramide synthase 5 isoform X1 [Rattus norvegicus]