Gene/Proteome Database (LMPD)
LMPD ID
LMP001696
Gene ID
Species
Homo sapiens (Human)
Gene Name
lipase, hepatic
Gene Symbol
Synonyms
HDLCQ12; HL; HTGL; LIPH
Chromosome
15
Map Location
15q21-q23
Summary
LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| hepatic triacylglycerol lipase precursor | |
|---|---|
| Refseq ID | NP_000227 |
| Protein GI | 194097335 |
| UniProt ID | P11150 |
| mRNA ID | NM_000236 |
| Length | 499 |
| RefSeq Status | REVIEWED |
| MDTSPLCFSILLVLCIFIQSSALGQSLKPEPFGRRAQAVETNKTLHEMKTRFLLFGETNQGCQIRINHPDTLQECGFNSSLPLVMIIHGWSVDGVLENWIWQMVAALKSQPAQPVNVGLVDWITLAHDHYTIAVRNTRLVGKEVAALLRWLEESVQLSRSHVHLIGYSLGAHVSGFAGSSIGGTHKIGRITGLDAAGPLFEGSAPSNRLSPDDANFVDAIHTFTREHMGLSVGIKQPIGHYDFYPNGGSFQPGCHFLELYRHIAQHGFNAITQTIKCSHERSVHLFIDSLLHAGTQSMAYPCGDMNSFSQGLCLSCKKGRCNTLGYHVRQEPRSKSKRLFLVTRAQSPFKVYHYQFKIQFINQTETPIQTTFTMSLLGTKEKMQKIPITLGKGIASNKTYSFLITLDVDIGELIMIKFKWENSAVWANVWDTVQTIIPWSTGPRHSGLVLKTIRVKAGETQQRMTFCSENTDDLLLRPTQEKIFVKCEIKSKTSKRKIR | |
| sig_peptide: 1..22 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2402 peptide sequence: MDTSPLCFSILLVLCIFIQSSA mat_peptide: 23..499 product: hepatic triacylglycerol lipase calculated_mol_wt: 53531 peptide sequence: LGQSLKPEPFGRRAQAVETNKTLHEMKTRFLLFGETNQGCQIRINHPDTLQECGFNSSLPLVMIIHGWSVDGVLENWIWQMVAALKSQPAQPVNVGLVDWITLAHDHYTIAVRNTRLVGKEVAALLRWLEESVQLSRSHVHLIGYSLGAHVSGFAGSSIGGTHKIGRITGLDAAGPLFEGSAPSNRLSPDDANFVDAIHTFTREHMGLSVGIKQPIGHYDFYPNGGSFQPGCHFLELYRHIAQHGFNAITQTIKCSHERSVHLFIDSLLHAGTQSMAYPCGDMNSFSQGLCLSCKKGRCNTLGYHVRQEPRSKSKRLFLVTRAQSPFKVYHYQFKIQFINQTETPIQTTFTMSLLGTKEKMQKIPITLGKGIASNKTYSFLITLDVDIGELIMIKFKWENSAVWANVWDTVQTIIPWSTGPRHSGLVLKTIRVKAGETQQRMTFCSENTDDLLLRPTQEKIFVKCEIKSKTSKRKIR | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005576 | IEA:UniProtKB-KW | C | extracellular region |
| GO:0004806 | IEA:InterPro | F | triglyceride lipase activity |
| GO:0006629 | IEA:InterPro | P | lipid metabolic process |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_6841 | Chylomicron-mediated lipid transport |
Domain Information
UniProt Annotations
Entry Information
Identical and Related Proteins
Unique RefSeq proteins for LMP001696 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 194097335 | RefSeq | NP_000227 | 499 | hepatic triacylglycerol lipase precursor |
Identical Sequences to LMP001696 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:194097335 | EMBL | CDH61623.1 | 499 | unnamed protein product [Homo sapiens] |
| GI:194097335 | EMBL | CDH93589.1 | 499 | unnamed protein product [Homo sapiens] |
| GI:194097335 | RefSeq | XP_005254429.1 | 499 | PREDICTED: hepatic triacylglycerol lipase isoform X1 [Homo sapiens] |
| GI:194097335 | RefSeq | XP_006720564.1 | 499 | PREDICTED: hepatic triacylglycerol lipase isoform X4 [Homo sapiens] |
| GI:194097335 | SwissProt | P11150.3 | 499 | RecName: Full=Hepatic triacylglycerol lipase; Short=HL; Short=Hepatic lipase; AltName: Full=Lipase member C; Flags: Precursor [Homo sapiens] |
Related Sequences to LMP001696 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:194097335 | GenBank | EAW77536.1 | 499 | lipase, hepatic [Homo sapiens] |
| GI:194097335 | GenBank | ACM84926.1 | 502 | Sequence 10424 from patent US 6812339 |
| GI:194097335 | GenBank | ACP57450.1 | 499 | Sequence 1579 from patent US 7482117 |
| GI:194097335 | GenBank | ADR83028.1 | 499 | lipase, hepatic, partial [synthetic construct] |
| GI:194097335 | GenBank | ADS31047.1 | 499 | Sequence 1579 from patent US 7781168 |
| GI:194097335 | GenBank | AIC54703.1 | 499 | LIPC, partial [synthetic construct] |