Gene/Proteome Database (LMPD)
Proteins
| lipoprotein lipase precursor | |
|---|---|
| Refseq ID | NP_032535 |
| Protein GI | 126723006 |
| UniProt ID | P11152 |
| mRNA ID | NM_008509 |
| Length | 474 |
| RefSeq Status | VALIDATED |
| MESKALLLVVLGVWLQSLTAFRGGVAAADAGRDFSDIESKFALRTPEDTAEDTCHLIPGLADSVSNCHFNHSSKTFVVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLYRAQQHYPVSAGYTKLVGNDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGVAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCNSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTEDGKQHNQAFEISLYGTVAESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMMKLKWISDSYFSWPDWWSSPSFVIERIRVKAGETQKKVIFCAREKVSHLQKGKDSAVFVKCHDKSLKKSG | |
| sig_peptide: 1..27 inference: non-experimental evidence, no additional details recorded note: Potential; propagated from UniProtKB/Swiss-Prot (P11152.3) calculated_mol_wt: 2830 peptide sequence: MESKALLLVVLGVWLQSLTAFRGGVAA mat_peptide: 28..474 product: Lipoprotein lipase experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P11152.3) calculated_mol_wt: 50297 peptide sequence: ADAGRDFSDIESKFALRTPEDTAEDTCHLIPGLADSVSNCHFNHSSKTFVVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLYRAQQHYPVSAGYTKLVGNDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGVAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCNSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTEDGKQHNQAFEISLYGTVAESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMMKLKWISDSYFSWPDWWSSPSFVIERIRVKAGETQKKVIFCAREKVSHLQKGKDSAVFVKCHDKSLKKSG | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0031225 | IEA:UniProtKB-KW | C | anchored component of membrane |
| GO:0009986 | IDA:BHF-UCL | C | cell surface |
| GO:0042627 | IEA:UniProtKB-KW | C | chylomicron |
| GO:0031012 | IEA:Ensembl | C | extracellular matrix |
| GO:0005615 | IDA:BHF-UCL | C | extracellular space |
| GO:0070062 | IEA:Ensembl | C | extracellular vesicular exosome |
| GO:0005886 | IEA:UniProtKB-KW | C | plasma membrane |
| GO:0034361 | IEA:UniProtKB-KW | C | very-low-density lipoprotein particle |
| GO:0008201 | IEA:UniProtKB-KW | F | heparin binding |
| GO:0004465 | IDA:MGI | F | lipoprotein lipase activity |
| GO:0017129 | IEA:Ensembl | F | triglyceride binding |
| GO:0004806 | IDA:BHF-UCL | F | triglyceride lipase activity |
| GO:0010886 | IEA:Ensembl | P | positive regulation of cholesterol storage |
| GO:0010744 | IGI:BHF-UCL | P | positive regulation of macrophage derived foam cell differentiation |
| GO:0010890 | IEA:Ensembl | P | positive regulation of sequestering of triglyceride |
| GO:0009409 | IEA:Ensembl | P | response to cold |
| GO:0042493 | IEA:Ensembl | P | response to drug |
| GO:0019432 | IEA:Ensembl | P | triglyceride biosynthetic process |
| GO:0019433 | IDA:BHF-UCL | P | triglyceride catabolic process |
| GO:0070328 | IEA:Ensembl | P | triglyceride homeostasis |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| mmu05010 | Alzheimer's disease |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Triacylglycerol + H(2)O = diacylglycerol + a carboxylate. |
| Developmental Stage | Maximum expression in adipose tissue during early development. In heart, low levels 6 days before birth increasing 278-fold as animals reach adulthood. {ECO:0000269|PubMed:2723548}. |
| Function | The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity). {ECO:0000250}. |
| Ptm | Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity. {ECO:0000250}. |
| Similarity | Belongs to the AB hydrolase superfamily. Lipase family. {ECO:0000305}. |
| Similarity | Contains 1 PLAT domain. {ECO:0000255|PROSITE- ProRule:PRU00152}. |
| Subcellular Location | Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}. Secreted {ECO:0000250}. Note=Locates to the plasma membrane of microvilli of hepatocytes with triacyl- glycerol-rich lipoproteins (TRL). Some of the bound LPL is then internalized and located inside non-coated endocytic vesicles (By similarity). {ECO:0000250}. |
| Subunit | Homodimer (By similarity). Interacts with APOC2; the interaction activates LPL activity in the presence of lipids (By similarity). Interacts with GPIHBP1. {ECO:0000250, ECO:0000269|PubMed:17403372}. |
| Tissue Specificity | Expressed in liver, epididymal fat, heart, psoas muscle, lactating mammary gland, adrenal, lung, and ovary. Highest levels in heart and adrenal gland. {ECO:0000269|PubMed:2723548}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP001697 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 126723006 | RefSeq | NP_032535 | 474 | lipoprotein lipase precursor |
Identical Sequences to LMP001697 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:126723006 | DBBJ | BAE29507.1 | 474 | unnamed protein product [Mus musculus] |
| GI:126723006 | DBBJ | BAE29577.1 | 474 | unnamed protein product [Mus musculus] |
| GI:126723006 | DBBJ | BAE29604.1 | 474 | unnamed protein product [Mus musculus] |
| GI:126723006 | DBBJ | BAE29618.1 | 474 | unnamed protein product [Mus musculus] |
| GI:126723006 | DBBJ | BAE31394.1 | 474 | unnamed protein product [Mus musculus] |
| GI:126723006 | SwissProt | P11152.3 | 474 | RecName: Full=Lipoprotein lipase; Short=LPL; Flags: Precursor [Mus musculus] |
Related Sequences to LMP001697 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:126723006 | DBBJ | BAC37646.1 | 474 | unnamed protein product [Mus musculus] |
| GI:126723006 | DBBJ | BAE30110.1 | 474 | unnamed protein product [Mus musculus] |
| GI:126723006 | DBBJ | BAE31178.1 | 474 | unnamed protein product [Mus musculus] |
| GI:126723006 | DBBJ | BAE29470.1 | 474 | unnamed protein product [Mus musculus] |
| GI:126723006 | DBBJ | BAE31487.1 | 474 | unnamed protein product [Mus musculus] |
| GI:126723006 | RefSeq | XP_006509626.1 | 475 | PREDICTED: lipoprotein lipase isoform X1 [Mus musculus] |