Gene/Proteome Database (LMPD)
LMPD ID
LMP001701
Gene ID
Species
Homo sapiens (Human)
Gene Name
sphingosine-1-phosphate receptor 3
Gene Symbol
Synonyms
EDG-3; EDG3; LPB3; S1P3
Alternate Names
sphingosine 1-phosphate receptor 3; S1P receptor 3; S1P receptor EDG3; S1P receptor Edg-3; sphingosine 1-phosphate receptor Edg-3; endothelial differentiation G-protein coupled receptor 3; G protein-coupled receptor, endothelial differentiation gene-3; endothelial differentiation, sphingolipid G-protein-coupled receptor, 3
Chromosome
9
Map Location
9q22.1-q22.2
Summary
This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| sphingosine 1-phosphate receptor 3 | |
|---|---|
| Refseq ID | NP_005217 |
| Protein GI | 38788193 |
| UniProt ID | Q99500 |
| mRNA ID | NM_005226 |
| Length | 378 |
| RefSeq Status | REVIEWED |
| MATALPPRLQPVRGNETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMVLIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFVALGASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLHNLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSSSRKVANHNNSERSMALLRTVVIVVSVFIACWSPLFILFLIDVACRVQACPILFKAQWFIVLAVLNSAMNPVIYTLASKEMRRAFFRLVCNCLVRGRGARASPIQPALDPSRSKSSSSNNSSHSPKVKEDLPHTAPSSCIMDKNAALQNGIFCN | |
Gene Information
Entrez Gene ID
Gene Name
sphingosine-1-phosphate receptor 3
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005887 | TAS:ProtInc | C | integral component of plasma membrane |
| GO:0005886 | IDA:UniProtKB | C | plasma membrane |
| GO:0004930 | TAS:ProtInc | F | G-protein coupled receptor activity |
| GO:0005178 | IPI:UniProtKB | F | integrin binding |
| GO:0008289 | TAS:ProtInc | F | lipid binding |
| GO:0038036 | IEA:InterPro | F | sphingosine-1-phosphate receptor activity |
| GO:0007193 | IEA:Ensembl | P | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway |
| GO:0009653 | TAS:ProtInc | P | anatomical structure morphogenesis |
| GO:0001816 | IEA:Ensembl | P | cytokine production |
| GO:0007186 | TAS:ProtInc | P | G-protein coupled receptor signaling pathway |
| GO:0006954 | TAS:ProtInc | P | inflammatory response |
| GO:1903141 | IMP:UniProtKB | P | negative regulation of establishment of endothelial barrier |
| GO:0008284 | TAS:ProtInc | P | positive regulation of cell proliferation |
| GO:0007204 | TAS:ProtInc | P | positive regulation of cytosolic calcium ion concentration |
| GO:0032651 | IEA:Ensembl | P | regulation of interleukin-1 beta production |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_19231 | G alpha (i) signalling events |
| REACT_18365 | Lysosphingolipid and LPA receptors |
Domain Information
UniProt Annotations
Entry Information
Gene Name
sphingosine-1-phosphate receptor 3
Protein Entry
S1PR3_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Function | Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis. |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Expressed in all tissues, but most abundantly in heart, placenta, kidney, and liver. |
Identical and Related Proteins
Unique RefSeq proteins for LMP001701 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 38788193 | RefSeq | NP_005217 | 378 | sphingosine 1-phosphate receptor 3 |
Identical Sequences to LMP001701 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:38788193 | GenBank | ADS30907.1 | 378 | Sequence 1439 from patent US 7781168 |
| GI:38788193 | GenBank | ADS30908.1 | 378 | Sequence 1440 from patent US 7781168 |
| GI:38788193 | GenBank | AEL91034.1 | 378 | Sequence 58 from patent US 7981598 |
| GI:38788193 | GenBank | AFO05712.1 | 378 | Sequence 350 from patent US 8216786 |
| GI:38788193 | GenBank | AFO05748.1 | 378 | Sequence 386 from patent US 8216786 |
| GI:38788193 | GenBank | AIC48674.1 | 378 | S1PR3, partial [synthetic construct] |
Related Sequences to LMP001701 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:38788193 | GenBank | JAA07346.1 | 378 | sphingosine-1-phosphate receptor 3 [Pan troglodytes] |
| GI:38788193 | GenBank | JAA07347.1 | 378 | sphingosine-1-phosphate receptor 3 [Pan troglodytes] |
| GI:38788193 | GenBank | JAA13108.1 | 378 | sphingosine-1-phosphate receptor 3 [Pan troglodytes] |
| GI:38788193 | GenBank | JAA32894.1 | 378 | sphingosine-1-phosphate receptor 3 [Pan troglodytes] |
| GI:38788193 | GenBank | JAA32908.1 | 378 | sphingosine-1-phosphate receptor 3 [Pan troglodytes] |
| GI:38788193 | RefSeq | XP_003806368.1 | 378 | PREDICTED: sphingosine 1-phosphate receptor 3 [Pan paniscus] |