Gene/Proteome Database (LMPD)

LMPD ID
LMP001705
Gene ID
19012
Species
Mus musculus (Mouse)
Gene Name
phosphatidic acid phosphatase type 2A
Gene Symbol
Ppap2a
Synonyms
Hic53; Hpic53; LPP-1; LPP1; PAP-2a; PAP2-alpha; PAP2a; mPAP
Alternate Names
lipid phosphate phosphohydrolase 1; 35 kDa PAP; phosphatidic acid phosphatase 2a; hydrogen peroxide inducible protein 53; phosphatidate phosphohydrolase type 2a
Chromosome
13
Map Location
13 D2.2|13
EC Number
3.1.3.4

Proteins

lipid phosphate phosphohydrolase 1 isoform 1
Refseq ID NP_032273
Protein GI 45592928
UniProt ID Q61469
mRNA ID NM_008247
Length 284
RefSeq Status VALIDATED
MFDKTRLPYVALDVICVLLAAMPMTILKLGKVYPFQRGFFCTDNSVKYPYHDSTIPSRILAILGLGLPIFSMSIGESLSVYFNVLHSNSFVGNPYIATIYKAVGAFLFGVSASQSLTDIAKYTIGSLRPHFLAICNPDWSKINCSDGYIEDYICQGNEEKVKEGRLSFYSGHSSFSMYCMLFVALYLQARMKGDWARLLRPMLQFGLIAFSIYVGLSRVSDYKHHWSDVTVGLIQGAAMAILVALYVSDFFKDTHSYKERKEEDPHTTLHETASSRNYSTNHEP
lipid phosphate phosphohydrolase 1 isoform 2
Refseq ID NP_032929
Protein GI 6679431
UniProt ID Q61469
mRNA ID NM_008903
Length 283
RefSeq Status VALIDATED
MFDKTRLPYVALDVICVLLAGLPFAILTSRHTPFQRGIFCNDDSIKYPYKEDTIPYALLGGIVIPFCIIVMSIGESLSVYFNVLHSNSFVGNPYIATIYKAVGAFLFGVSASQSLTDIAKYTIGSLRPHFLAICNPDWSKINCSDGYIEDYICQGNEEKVKEGRLSFYSGHSSFSMYCMLFVALYLQARMKGDWARLLRPMLQFGLIAFSIYVGLSRVSDYKHHWSDVTVGLIQGAAMAILVALYVSDFFKDTHSYKERKEEDPHTTLHETASSRNYSTNHEP

Gene Information

Entrez Gene ID
19012
Gene Name
phosphatidic acid phosphatase type 2A
Gene Symbol
Ppap2a
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005887 TAS:MGI C integral component of plasma membrane
GO:0016020 ISS:UniProtKB C membrane
GO:0005886 TAS:MGI C plasma membrane
GO:0008195 ISS:UniProtKB F phosphatidate phosphatase activity
GO:0006672 TAS:MGI P ceramide metabolic process
GO:0006651 TAS:MGI P diacylglycerol biosynthetic process
GO:0006470 IDA:MGI P protein dephosphorylation
GO:0007165 TAS:MGI P signal transduction
GO:0006670 TAS:MGI P sphingosine metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu04975 Fat digestion and absorption
mmu04666 Fc gamma R-mediated phagocytosis
mmu00600 Sphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR028670 Lipid phosphate phosphohydrolase 1
IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase

UniProt Annotations

Entry Information

Gene Name
phosphatidic acid phosphatase type 2A
Protein Entry
LPP1_MOUSE
UniProt ID
Q61469
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q61469-1; Sequence=Displayed; Name=2; IsoId=Q61469-2; Sequence=VSP_009652;
Catalytic Activity A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.
Function Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), diacyl glycerol pyrophosphate (DGPP), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > C-1-P > S-1-P.
Induction Moderately, by hydrogen peroxide, calcium ionophore and dexamethasone. {ECO:0000269|PubMed:7556647}.
Miscellaneous Overexpression elicited a number of phenotypic alteration without affecting several aspects of LPA signaling. Phenotypic abnormalities affect primarily three organs: the liver, the skin, and the reproductive organs. There is a reduction on body size, birth weight, abnormalities in fur growth, and a severely impaired spermatogenesis.
Ptm N-glycosylated. Contains high-mannose oligosaccharide.
Sequence Caution Sequence=AAA85353.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};
Similarity Belongs to the PA-phosphatase related phosphoesterase family. {ECO:0000305}.
Subcellular Location Cell membrane; Multi-pass membrane protein. Note=Found predominantly in plasma membrane.
Subunit Homodimer. This complex seems not to be involved in substrate recognition, it may confer only structural or functional stability. {ECO:0000269|PubMed:14725715}.
Tissue Specificity Highly expressed in kidney and lung. Almost undetectable in brain, heart, bone, muscle or spleen.

Identical and Related Proteins

Unique RefSeq proteins for LMP001705 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
45592928 RefSeq NP_032273 284 lipid phosphate phosphohydrolase 1 isoform 1
6679431 RefSeq NP_032929 283 lipid phosphate phosphohydrolase 1 isoform 2

Identical Sequences to LMP001705 proteins

Reference Database Accession Length Protein Name
GI:45592928 DBBJ BAC36724.1 284 unnamed protein product [Mus musculus]
GI:6679431 GenBank AAE73274.1 283 Sequence 3 from patent US 6242179
GI:6679431 GenBank AAO95202.1 283 Sequence 53 from patent US 6495739
GI:6679431 GenBank AAP04434.1 283 lipid phosphate phosphatase 1 [Mus musculus]
GI:45592928 GenBank AAP04435.1 284 lipid phosphate phosphatase 1a [Mus musculus]
GI:45592928 GenBank AAH61161.1 284 Phosphatidic acid phosphatase type 2A [Mus musculus]
GI:45592928 GenBank ABK42258.1 284 PA-phosphatase [synthetic construct]
GI:6679431 GenBank ABL31794.1 283 Sequence 9 from patent US 7135314
GI:6679431 GenBank EDL18405.1 283 phosphatidic acid phosphatase 2a, isoform CRA_a [Mus musculus]
GI:6679431 SwissProt Q61469.1 283 RecName: Full=Lipid phosphate phosphohydrolase 1; AltName: Full=35 kDa PAP; Short=mPAP; AltName: Full=Hydrogen peroxide-inducible protein 53; Short=Hic53; AltName: Full=PAP2-alpha; AltName: Full=Phosphatidate phosphohydrolase type 2a; AltName: Full=Phosphatidic acid phosphatase 2a; Short=PAP-2a; Short=PAP2a [Mus musculus]

Related Sequences to LMP001705 proteins

Reference Database Accession Length Protein Name
GI:45592928 DBBJ BAA12335.1 283 Phosphatidic acid phosphatase [Mus musculus]
GI:45592928 GenBank AAE73274.1 283 Sequence 3 from patent US 6242179
GI:6679431 GenBank AAO16874.1 325 PAP2A-trimeric MYC tag fusion protein [synthetic construct]
GI:6679431 GenBank AAO16875.1 534 PAP2A-GFP fusion protein [synthetic construct]
GI:6679431 GenBank AAP04435.1 284 lipid phosphate phosphatase 1a [Mus musculus]
GI:6679431 GenBank AAH61161.1 284 Phosphatidic acid phosphatase type 2A [Mus musculus]
GI:6679431 GenBank ABK42258.1 284 PA-phosphatase [synthetic construct]
GI:45592928 GenBank EDL18406.1 354 phosphatidic acid phosphatase 2a, isoform CRA_b, partial [Mus musculus]
GI:6679431 RefSeq NP_032273.1 284 lipid phosphate phosphohydrolase 1 isoform 1 [Mus musculus]
GI:45592928 RefSeq XP_006517634.1 290 PREDICTED: lipid phosphate phosphohydrolase 1 isoform X1 [Mus musculus]
GI:45592928 RefSeq XP_006517635.1 280 PREDICTED: lipid phosphate phosphohydrolase 1 isoform X2 [Mus musculus]
GI:45592928 RefSeq XP_006517636.1 263 PREDICTED: lipid phosphate phosphohydrolase 1 isoform X3 [Mus musculus]