Gene/Proteome Database (LMPD)

LMPD ID
LMP001723
Gene ID
122970
Species
Homo sapiens (Human)
Gene Name
acyl-CoA thioesterase 4
Gene Symbol
ACOT4
Synonyms
PTE-Ib; PTE1B; PTE2B
Alternate Names
acyl-coenzyme A thioesterase 4; PTE-2b; peroxisomal acyl-CoA thioesterase 2B; peroxisomal long-chain acyl-CoA thioesterase Ib; peroxisomal acyl coenzyme A thioester hydrolase Ib
Chromosome
14
Map Location
14q24.3
EC Number
3.1.2.2

Proteins

acyl-coenzyme A thioesterase 4
Refseq ID NP_689544
Protein GI 187761341
UniProt ID Q8N9L9
mRNA ID NM_152331
Length 421
RefSeq Status VALIDATED
MSATLILEPPGRCCWNEPVRIAVRGLAPEQRVTLRASLRDEKGALFRAHARYCADARGELDLERAPALGGSFAGLEPMGLLWALEPEKPFWRFLKRDVQIPFVVELEVLDGHDPEPGRLLCQAQHERHFLPPGVRRQSVRAGRVRATLFLPPGPGPFPGIIDIFGIGGGLLEYRASLLAGHGFATLALAYYNFEDLPNNMDNISLEYFEEAVCYMLQHPQVKGPGIGLLGISLGADICLSMASFLKNVSATVSINGSGISGNTAINYKHSSIPPLGYDLRRIKVAFSGLVDIVDIRNALVGGYKNPSMIPIEKAQGPILLIVGQDDHNWRSELYAQTVSERLQAHGKEKPQIICYPGTGHYIEPPYFPLCPASLHRLLNKHVIWGGEPRAHSKAQEDAWKQILAFFCKHLGGTQKTAVPKL

Gene Information

Entrez Gene ID
122970
Gene Name
acyl-CoA thioesterase 4
Gene Symbol
ACOT4
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005777 IDA:UniProtKB C peroxisome
GO:0047617 IDA:UniProtKB F acyl-CoA hydrolase activity
GO:0052689 IEA:UniProtKB-KW F carboxylic ester hydrolase activity
GO:0016290 IEA:UniProtKB-EC F palmitoyl-CoA hydrolase activity
GO:0005102 IPI:UniProtKB F receptor binding
GO:0004778 IDA:UniProtKB F succinyl-CoA hydrolase activity
GO:0006637 IDA:HGNC P acyl-CoA metabolic process
GO:0043649 IDA:UniProtKB P dicarboxylic acid catabolic process
GO:0043648 IDA:HGNC P dicarboxylic acid metabolic process
GO:0001676 IDA:HGNC P long-chain fatty acid metabolic process
GO:0032788 IDA:HGNC P saturated monocarboxylic acid metabolic process
GO:0046459 IDA:HGNC P short-chain fatty acid metabolic process
GO:0006104 IDA:HGNC P succinyl-CoA metabolic process
GO:0032789 IDA:HGNC P unsaturated monocarboxylic acid metabolic process
GO:0000038 IDA:HGNC P very long-chain fatty acid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa01040 Biosynthesis of unsaturated fatty acids
hsa00062 Fatty acid elongation

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-5996 oleate biosynthesis II (animals)
PWY-5972 stearate biosynthesis I (animals)

Domain Information

InterPro Annotations

Accession Description
IPR006862 Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
IPR016662 Acyl-CoA thioesterase, long chain
IPR029058 Alpha/Beta hydrolase fold
IPR014940 BAAT/Acyl-CoA thioester hydrolase C-terminal

UniProt Annotations

Entry Information

Gene Name
acyl-CoA thioesterase 4
Protein Entry
ACOT4_HUMAN
UniProt ID
Q8N9L9
Species
Human

Comments

Comment Type Description
Biophysicochemical Properties Kinetic parameters: KM=14 uM for succinyl-CoA ; KM=147 uM for glutaryl-CoA ; KM=3.4 uM for C14-acyl-CoA ; Vmax=581 nmol/min/mg enzyme toward succinyl-CoA ; Vmax=132 nmol/min/mg enzyme toward glutaryl-CoA ; Vmax=137 nmol/min/mg enzyme toward C14-acyl-CoA ;
Catalytic Activity Palmitoyl-CoA + H(2)O = CoA + palmitate.
Function Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Succinyl-CoA thioesterase that also hydrolyzes long chain saturated and unsaturated monocarboxylic acyl-CoAs.
Miscellaneous Human ACOT4 may have acquired the combined activities of mouse ACOT3, ACOT4, and ACOT5.
Similarity Belongs to the C/M/P thioester hydrolase family.
Subcellular Location Peroxisome .
Tissue Specificity Strongest expression in liver and kidney and weaker expression in placenta, heart, and muscle.

Identical and Related Proteins

Unique RefSeq proteins for LMP001723 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
187761341 RefSeq NP_689544 421 acyl-coenzyme A thioesterase 4

Identical Sequences to LMP001723 proteins

Reference Database Accession Length Protein Name
GI:187761341 GenBank AAI17342.1 421 Acyl-CoA thioesterase 4 [Homo sapiens]
GI:187761341 GenBank AAI17344.1 421 Acyl-CoA thioesterase 4 [Homo sapiens]
GI:187761341 GenBank EAW81121.1 421 acyl-CoA thioesterase 4, isoform CRA_b [Homo sapiens]
GI:187761341 GenBank AIC52956.1 421 ACOT4, partial [synthetic construct]
GI:187761341 SwissProt Q8N9L9.2 421 RecName: Full=Acyl-coenzyme A thioesterase 4; Short=Acyl-CoA thioesterase 4; AltName: Full=PTE-2b; AltName: Full=Peroxisomal acyl coenzyme A thioester hydrolase Ib; AltName: Full=Peroxisomal long-chain acyl-CoA thioesterase Ib; Short=PTE-Ib [Homo sapiens]

Related Sequences to LMP001723 proteins

Reference Database Accession Length Protein Name
GI:187761341 EMBL CAD35497.1 421 unnamed protein product [Homo sapiens]
GI:187761341 GenBank AAH90945.1 421 Acyl-CoA thioesterase 4 [Homo sapiens]
GI:187761341 GenBank AHD74848.1 421 Sequence 15552 from patent US 8586006
GI:187761341 RefSeq XP_510049.2 421 PREDICTED: acyl-coenzyme A thioesterase 4 [Pan troglodytes]
GI:187761341 RefSeq XP_003846022.1 421 PREDICTED: LOW QUALITY PROTEIN: acyl-coenzyme A thioesterase 4 [Pan paniscus]
GI:187761341 RefSeq XP_004055467.1 421 PREDICTED: acyl-coenzyme A thioesterase 4 [Gorilla gorilla gorilla]