Gene/Proteome Database (LMPD)

LMPD ID
LMP001728
Gene ID
9373
Species
Homo sapiens (Human)
Gene Name
phospholipase A2-activating protein
Gene Symbol
PLAA
Synonyms
DOA1; PLA2P; PLAP
Alternate Names
phospholipase A-2-activating protein; DOA1 homolog; phospholipase A2 activating protein
Chromosome
9
Map Location
9p21

Proteins

phospholipase A-2-activating protein
Refseq ID NP_001026859
Protein GI 72534670
UniProt ID Q9Y263
mRNA ID NM_001031689
Length 795
RefSeq Status VALIDATED
MTSGATRYRLSCSLRGHELDVRGLVCCAYPPGAFVSVSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSCVCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSSGKFGTLLSGSWDTTAKVWLNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWKAGRCERTFSGHEDCVRGLAILSETEFLSCANDASIRRWQITGECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIWKHGECAQTIRLPAQSIWCCCVLDNGDIVVGASDGIIRVFTESEDRTASAEEIKAFEKELSHATIDSKTGDLGDINAEQLPGREHLNEPGTREGQTRLIRDGEKVEAYQWSVSEGRWIKIGDVVGSSGANQQTSGKVLYEGKEFDYVFSIDVNEGGPSYKLPYNTSDDPWLTAYNFLQKNDLNPMFLDQVAKFIIDNTKGQMLGLGNPSFSDPFTGGGRYVPGSSGSSNTLPTADPFTGAGRYVPGSASMGTTMAGVDPFTGNSAYRSAASKTMNIYFPKKEAVTFDQANPTQILGKLKELNGTAPEEKKLTEDDLILLEKILSLICNSSSEKPTVQQLQILWKAINCPEDIVFPALDILRLSIKHPSVNENFCNEKEGAQFSSHLINLLNPKGKPANQLLALRTFCNCFVGQAGQKLMMSQRESLMSHAIELKSGSNKNIHIALATLALNYSVCFHKDHNIEGKAQCLSLISTILEVVQDLEATFRLLVALGTLISDDSNAVQLAKSLGVDSQIKKYSSVSEPAKVSECCRFILNLL

Gene Information

Entrez Gene ID
9373
Gene Name
phospholipase A2-activating protein
Gene Symbol
PLAA
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IDA:UniProtKB C extracellular vesicular exosome
GO:0016005 TAS:ProtInc F phospholipase A2 activator activity
GO:0006954 IEA:Ensembl P inflammatory response
GO:0006644 TAS:ProtInc P phospholipid metabolic process
GO:0007165 TAS:ProtInc P signal transduction

KEGG Pathway Links

KEGG Pathway ID Description
hsa04141 Protein processing in endoplasmic reticulum
ko04141 Protein processing in endoplasmic reticulum

Domain Information

InterPro Annotations

Accession Description
IPR016024 Armadillo-type fold
IPR015155 PLAA family ubiquitin binding, PFU
IPR013535 PUL
IPR017986 WD40-repeat-containing domain
IPR015943 WD40/YVTN repeat-like-containing domain
IPR001680 WD40_repeat

UniProt Annotations

Entry Information

Gene Name
phospholipase A2-activating protein
Protein Entry
PLAP_HUMAN
UniProt ID
Q9Y263
Species
Human

Comments

Comment Type Description
Domain The PFU domain mediates interaction with ubiquitin.
Domain The PUL domain is composed of 6 armadillo-like repeats and mediates the interaction with VCP C-terminus.
Function Involved in the maintenance of ubiquitin levels.
Interaction Q76353:- (xeno); NbExp=3; IntAct=EBI-1994037, EBI-6248077;
Sequence Caution Sequence=AAD03030.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=AAD42075.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=AAD42075.1; Type=Frameshift; Positions=698; Evidence= ; Sequence=BAA92105.1; Type=Erroneous termination; Positions=545; Note=Translated as Gln.; Evidence= ; Sequence=BAD97264.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=CAB42881.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=CAH72641.1; Type=Erroneous gene model prediction; Evidence= ;
Similarity Belongs to the WD repeat PLAP family.
Similarity Contains 1 PFU domain. {ECO
Similarity Contains 1 PUL domain. {ECO
Similarity Contains 6 ARM repeats.
Similarity Contains 7 WD repeats. {ECO
Subunit Interacts with ubiquitin. Interacts with VCP.

Identical and Related Proteins

Unique RefSeq proteins for LMP001728 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
72534670 RefSeq NP_001026859 795 phospholipase A-2-activating protein

Identical Sequences to LMP001728 proteins

Reference Database Accession Length Protein Name
GI:72534670 DBBJ BAG10899.1 795 phospholipase A2-activating protein, partial [synthetic construct]
GI:72534670 GenBank ABW63510.1 795 Sequence 21 from patent US 7282209
GI:72534670 GenBank ABX90727.1 795 Sequence 21 from patent US 7285398
GI:72534670 GenBank ACV97572.1 795 Sequence 21 from patent US 7544491
GI:72534670 GenBank ADT50523.1 795 Sequence 2540 from patent US 7842467
GI:72534670 GenBank AFL62061.1 795 Sequence 21 from patent US 8187819

Related Sequences to LMP001728 proteins

Reference Database Accession Length Protein Name
GI:72534670 GenBank ABI10787.1 855 Sequence 45 from patent US 7083793
GI:72534670 GenBank ABW63528.1 855 Sequence 45 from patent US 7282209
GI:72534670 GenBank ABX90745.1 855 Sequence 45 from patent US 7285398
GI:72534670 GenBank ACV97590.1 855 Sequence 45 from patent US 7544491
GI:72534670 GenBank AFL62079.1 855 Sequence 45 from patent US 8187819
GI:72534670 GenBank JAA08891.1 795 phospholipase A2-activating protein [Pan troglodytes]