Gene/Proteome Database (LMPD)
LMPD ID
LMP001732
Gene ID
Species
Homo sapiens (Human)
Gene Name
peroxiredoxin 6
Gene Symbol
Synonyms
1-Cys; AOP2; HEL-S-128m; NSGPx; PRX; aiPLA2; p29
Alternate Names
peroxiredoxin-6; 1-Cys PRX; 24 kDa protein; 1-Cys peroxiredoxin; antioxidant protein 2; liver 2D page spot 40; red blood cells page spot 12; non-selenium glutathione peroxidase; acidic calcium-independent phospholipase A2; epididymis secretory sperm binding protein Li 128m
Chromosome
1
Map Location
1q25.1
EC Number
1.11.1.15
Summary
The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| peroxiredoxin-6 | |
|---|---|
| Refseq ID | NP_004896 |
| Protein GI | 4758638 |
| UniProt ID | P30041 |
| mRNA ID | NM_004905 |
| Length | 224 |
| RefSeq Status | REVIEWED |
| MPGGLLLGDVAPNFEANTTVGRIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLGMLDPAEKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRVATPVDWKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRYTPQP | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005737 | IDA:UniProtKB | C | cytoplasm |
| GO:0031410 | IEA:UniProtKB-KW | C | cytoplasmic vesicle |
| GO:0005829 | NAS:UniProtKB | C | cytosol |
| GO:0005615 | IDA:UniProt | C | extracellular space |
| GO:0070062 | IDA:UniProtKB | C | extracellular vesicular exosome |
| GO:0005764 | IEA:UniProtKB-KW | C | lysosome |
| GO:0016020 | IDA:UniProtKB | C | membrane |
| GO:0016209 | NAS:UniProtKB | F | antioxidant activity |
| GO:0004602 | IEA:UniProtKB-EC | F | glutathione peroxidase activity |
| GO:0051920 | IEA:UniProtKB-EC | F | peroxiredoxin activity |
| GO:0004623 | IDA:UniProtKB | F | phospholipase A2 activity |
| GO:0042744 | IEA:Ensembl | P | hydrogen peroxide catabolic process |
| GO:0009395 | IDA:UniProtKB | P | phospholipid catabolic process |
| GO:0006979 | IDA:UniProtKB | P | response to oxidative stress |
KEGG Pathway Links
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_120956 | Cellular responses to stress |
| REACT_172715 | Detoxification of Reactive Oxygen Species |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | 2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH. |
| Catalytic Activity | 2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O. |
| Function | Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. |
| Interaction | P29991:- (xeno); NbExp=3; IntAct=EBI-2255129, EBI-8826747; P09211:GSTP1; NbExp=2; IntAct=EBI-2255129, EBI-353467; |
| Miscellaneous | Irreversibly inactivated by overoxidation of Cys-47 (to Cys-SO(3)H) upon oxidative stress. |
| Miscellaneous | The active site is the redox-active Cys-47 oxidized to Cys-SOH. Unlike 2-Cys peroxiredoxins, PRDX6 conserves only this peroxidatic cysteine. To regenerate and activate the enzyme, the oxidized form is directly reduced to cysteine by glutathione and not thioredoxin. |
| Similarity | Belongs to the AhpC/TSA family. Rehydrin subfamily. |
| Similarity | Contains 1 thioredoxin domain. {ECO |
| Subcellular Location | Cytoplasm {ECO |
| Subunit | Homotetramer. Interacts with GSTP1; mediates PRDX6 glutathionylation and regeneration. May interact with HTR2A (By similarity). Interacts with APEX1 and STH. May interact with FAM168B. {ECO |
| Web Resource | Name=NIEHS SNPs; URL="http://egp.gs.washington.edu/data/prdx6/"; |
Identical and Related Proteins
Unique RefSeq proteins for LMP001732 (as displayed in Record Overview)
Identical Sequences to LMP001732 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4758638 | GenBank | AEU43322.1 | 224 | Sequence 71 from patent US 8052970 |
| GI:4758638 | GenBank | AEU43492.1 | 224 | Sequence 241 from patent US 8052970 |
| GI:4758638 | GenBank | AHD70560.1 | 224 | Sequence 3235 from patent US 8586006 |
| GI:4758638 | GenBank | AIC50395.1 | 224 | PRDX6, partial [synthetic construct] |
| GI:4758638 | RefSeq | XP_004027965.1 | 224 | PREDICTED: peroxiredoxin-6 [Gorilla gorilla gorilla] |
| GI:4758638 | RefSeq | XP_009454110.1 | 224 | PREDICTED: peroxiredoxin-6 [Pan troglodytes] |
Related Sequences to LMP001732 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4758638 | EMBL | CAH92320.1 | 224 | hypothetical protein [Pongo abelii] |
| GI:4758638 | GenBank | AAV20778.1 | 223 | Sequence 1038 from patent US 6753314 |
| GI:4758638 | GenBank | ADA18554.1 | 223 | Sequence 378 from patent US 7608413 |
| GI:4758638 | GenBank | AEN34450.1 | 223 | Sequence 378 from patent US 7998689 |
| GI:4758638 | RefSeq | XP_003258941.1 | 224 | PREDICTED: peroxiredoxin-6 [Nomascus leucogenys] |
| GI:4758638 | SwissProt | Q5R7E0.3 | 224 | RecName: Full=Peroxiredoxin-6; AltName: Full=Non-selenium glutathione peroxidase; Short=NSGPx [Pongo abelii] |