Gene/Proteome Database (LMPD)
Proteins
mevalonate kinase | |
---|---|
Refseq ID | NP_076045 |
Protein GI | 12963731 |
UniProt ID | Q9R008 |
mRNA ID | NM_023556 |
Length | 395 |
RefSeq Status | PROVISIONAL |
MLSEALLVSAPGKVILHGEHAVVHGKVALAAALNLRTFLLLRPQSNGKVSVNLPNIGIKQVWDVGMLQRLDTSFLEQGDVSVPTLEQLEKLKKMGDLPRDRAGNEGMALLAFLYLYLAICRKQRTLPSLDMVVWSELPPGAGLGSSAAYSVCLAAALLTACEEVSNPLKDGVSVSRWPEEDLKSINKWAFEGERVIHGNPSGVDNAVSTWGGALRFQQGTMSSLKSLPSLQILLTNTKVPRSTKALVAAVRSRLTKFPEIVAPLLTSIDAISLECERVLGEMVAAPVPEQYLVLEELIDMNQHHLNALGVGHNSLDQLCQVTAAHGLHSKLTGAGGGGCGITLLKPGLEQATVEAAKQALTSCGFDCWETSIGAPGVSTHSAAAVGDPVRQALGL |
Gene Information
Gene Ontology (GO Annotations)
GO ID | Source | Type | Description |
---|---|---|---|
GO:0005829 | IEA:Ensembl | C | cytosol |
GO:0070062 | IEA:Ensembl | C | extracellular vesicular exosome |
GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
GO:0004496 | IDA:MGI | F | mevalonate kinase activity |
GO:0006695 | IEA:UniProtKB-KW | P | cholesterol biosynthetic process |
GO:0019287 | IEA:UniProtKB-UniPathway | P | isopentenyl diphosphate biosynthetic process, mevalonate pathway |
GO:0050728 | IEA:Ensembl | P | negative regulation of inflammatory response |
KEGG Pathway Links
Domain Information
InterPro Annotations
Accession | Description |
---|---|
IPR006203 | GHMP kinase, ATP-binding, conserved site |
IPR013750 | GHMP kinase, C-terminal domain |
IPR006204 | GHMP kinase N-terminal domain |
IPR006206 | Mevalonate/galactokinase |
IPR006205 | Mevalonate kinase |
IPR020568 | Ribosomal protein S5 domain 2-type fold |
IPR014721 | Ribosomal protein S5 domain 2-type fold, subgroup |
UniProt Annotations
Entry Information
Comments
Comment Type | Description |
---|---|
Catalytic Activity | ATP + (R)-mevalonate = ADP + (R)-5- phosphomevalonate. |
Enzyme Regulation | Farnesyl- and geranyl-pyrophosphates are competitive inhibitors. {ECO:0000250}. |
Function | May be a regulatory site in cholesterol biosynthetic pathway. |
Pathway | Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3. |
Similarity | Belongs to the GHMP kinase family. Mevalonate kinase subfamily. {ECO:0000305}. |
Subcellular Location | Cytoplasm {ECO:0000250}. |
Subunit | Homodimer. {ECO:0000250}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP001743 (as displayed in Record Overview)
Identical Sequences to LMP001743 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:12963731 | GenBank | AAF00700.1 | 395 | mevalonate kinase [Mus musculus] |
GI:12963731 | GenBank | AAH05606.1 | 395 | Mevalonate kinase [Mus musculus] |
GI:12963731 | GenBank | ADI53345.1 | 395 | Sequence 3 from patent US 7422884 |
GI:12963731 | GenBank | AGD02018.1 | 395 | Sequence 31 from patent US 8338155 |
GI:12963731 | RefSeq | XP_006530248.1 | 395 | PREDICTED: mevalonate kinase isoform X3 [Mus musculus] |
GI:12963731 | SwissProt | Q9R008.1 | 395 | RecName: Full=Mevalonate kinase; Short=MK [Mus musculus] |
Related Sequences to LMP001743 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:12963731 | DBBJ | BAE28997.1 | 407 | unnamed protein product [Mus musculus] |
GI:12963731 | GenBank | EDM13937.1 | 395 | mevalonate kinase, isoform CRA_a [Rattus norvegicus] |
GI:12963731 | GenBank | ADI53346.1 | 395 | Sequence 4 from patent US 7422884 |
GI:12963731 | PDB | 1KVK | 395 | Chain A, The Structure Of Binary Complex Between A Mammalian Mevalonate Kinase And Atp: Insights Into The Reaction Mechanism And Human Inherited Disease |
GI:12963731 | RefSeq | XP_006530246.1 | 407 | PREDICTED: mevalonate kinase isoform X1 [Mus musculus] |
GI:12963731 | RefSeq | XP_006530247.1 | 407 | PREDICTED: mevalonate kinase isoform X2 [Mus musculus] |