Gene/Proteome Database (LMPD)

LMPD ID
LMP001747
Gene ID
16803
Species
Mus musculus (Mouse)
Gene Name
lipopolysaccharide binding protein
Gene Symbol
Lbp
Synonyms
Bpifd2; Ly88
Alternate Names
lipopolysaccharide-binding protein
Chromosome
2
Map Location
2 H1|2 78.72 cM

Proteins

lipopolysaccharide-binding protein precursor
Refseq ID NP_032515
Protein GI 113865991
UniProt ID Q61805
mRNA ID NM_008489
Length 481
RefSeq Status VALIDATED
MKAGTGPLLSTLLGLLFLSIQGTGGVNPGVVARITDKGLAYAAKEGLVALQRELYKITLPDFSGDFKIKAVGRGQYEFHSLEIQNCELRGSSLKLLPGQGLSLAISDSSIGVRGKWKVRKSFLKLHGSFDLDVKGVTISVDLLLGMDPSGRPTVSASGCSSRICDLDVHISGNVGWLLNLFHNQIESKLQKVLENKVCEMIQKSVTSDLQPYLQTLPVTAEIDNVLGIDYSLVAAPQAKAQVLDVMFKGEIFNRNHRSPVATPTPTMSLPEDSKQMVYFAISDYAFNIASRVYHQAGYLNFSITDDMLPHDSGIRLNTKAFRPFTPQIYKKYPDMKLELLGTVVSAPILNVSPGNLSLAPQMEIEGFVILPTSAREPVFRLGVVTNVFASLTFNNSKVTGMLHPDKAQVRLIESKVGMFNVNLFQAFLNYYLLNSLYPDVNAELAQGFPLPLPRHIQLHDLDFQIRKDFLYLGANVQYMRV
sig_peptide: 1..24 inference: non-experimental evidence, no additional details recorded note: Potential; propagated from UniProtKB/Swiss-Prot (Q61805.2) calculated_mol_wt: 2389 peptide sequence: MKAGTGPLLSTLLGLLFLSIQGTG mat_peptide: 25..481 product: Lipopolysaccharide-binding protein experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q61805.2) calculated_mol_wt: 50685 peptide sequence: GVNPGVVARITDKGLAYAAKEGLVALQRELYKITLPDFSGDFKIKAVGRGQYEFHSLEIQNCELRGSSLKLLPGQGLSLAISDSSIGVRGKWKVRKSFLKLHGSFDLDVKGVTISVDLLLGMDPSGRPTVSASGCSSRICDLDVHISGNVGWLLNLFHNQIESKLQKVLENKVCEMIQKSVTSDLQPYLQTLPVTAEIDNVLGIDYSLVAAPQAKAQVLDVMFKGEIFNRNHRSPVATPTPTMSLPEDSKQMVYFAISDYAFNIASRVYHQAGYLNFSITDDMLPHDSGIRLNTKAFRPFTPQIYKKYPDMKLELLGTVVSAPILNVSPGNLSLAPQMEIEGFVILPTSAREPVFRLGVVTNVFASLTFNNSKVTGMLHPDKAQVRLIESKVGMFNVNLFQAFLNYYLLNSLYPDVNAELAQGFPLPLPRHIQLHDLDFQIRKDFLYLGANVQYMRV

Gene Information

Entrez Gene ID
16803
Gene Name
lipopolysaccharide binding protein
Gene Symbol
Lbp
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009986 IDA:BHF-UCL C cell surface
GO:0005615 IDA:BHF-UCL C extracellular space
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0001530 IDA:MGI F lipopolysaccharide binding
GO:0070891 IEA:Ensembl F lipoteichoic acid binding
GO:0005102 IDA:BHF-UCL F receptor binding
GO:0006953 IMP:BHF-UCL P acute-phase response
GO:0071223 IEA:Ensembl P cellular response to lipoteichoic acid
GO:0050829 IMP:BHF-UCL P defense response to Gram-negative bacterium
GO:0050830 IMP:BHF-UCL P defense response to Gram-positive bacterium
GO:0032490 IEA:Ensembl P detection of molecule of bacterial origin
GO:0045087 IMP:BHF-UCL P innate immune response
GO:0002232 IMP:MGI P leukocyte chemotaxis involved in inflammatory response
GO:0015920 IEA:Ensembl P lipopolysaccharide transport
GO:0031663 IEA:Ensembl P lipopolysaccharide-mediated signaling pathway
GO:0002281 IDA:BHF-UCL P macrophage activation involved in immune response
GO:0044130 IMP:MGI P negative regulation of growth of symbiont in host
GO:0032720 IEA:Ensembl P negative regulation of tumor necrosis factor production
GO:0008228 IC:BHF-UCL P opsonization
GO:0032722 IMP:MGI P positive regulation of chemokine production
GO:0032755 IEA:Ensembl P positive regulation of interleukin-6 production
GO:0032757 IEA:Ensembl P positive regulation of interleukin-8 production
GO:0043032 IEA:Ensembl P positive regulation of macrophage activation
GO:0090023 IMP:MGI P positive regulation of neutrophil chemotaxis
GO:0060265 IMP:BHF-UCL P positive regulation of respiratory burst involved in inflammatory response
GO:0034145 IEA:Ensembl P positive regulation of toll-like receptor 4 signaling pathway
GO:0042535 IMP:MGI P positive regulation of tumor necrosis factor biosynthetic process
GO:0032760 IDA:BHF-UCL P positive regulation of tumor necrosis factor production
GO:0032496 IMP:BHF-UCL P response to lipopolysaccharide

KEGG Pathway Links

KEGG Pathway ID Description
mmu04064 NF-kappa B signaling pathway
mmu05132 Salmonella infection
mmu04620 Toll-like receptor signaling pathway
mmu05152 Tuberculosis

Domain Information

InterPro Annotations

Accession Description
IPR017943 Bactericidal permeability-increasing protein, alpha/beta domain
IPR001124 Lipid-binding serum glycoprotein, C-terminal
IPR017942 Lipid-binding serum glycoprotein, N-terminal
IPR017954 Lipid-binding serum glycoprotein, conserved site

UniProt Annotations

Entry Information

Gene Name
lipopolysaccharide binding protein
Protein Entry
LBP_MOUSE
UniProt ID
Q61805
Species
Mouse

Comments

Comment Type Description
Function Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria, and acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (By similarity). {ECO:0000250}.
Similarity Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. {ECO:0000305}.
Subcellular Location Secreted.
Subunit When bound to LPS, interacts (via C-terminus) with soluble CD14. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001747 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
113865991 RefSeq NP_032515 481 lipopolysaccharide-binding protein precursor

Identical Sequences to LMP001747 proteins

Reference Database Accession Length Protein Name
GI:113865991 GenBank EDL06262.1 481 lipopolysaccharide binding protein [Mus musculus]
GI:113865991 SwissProt Q61805.2 481 RecName: Full=Lipopolysaccharide-binding protein; Short=LBP; Flags: Precursor [Mus musculus]

Related Sequences to LMP001747 proteins

Reference Database Accession Length Protein Name
GI:113865991 EMBL CAA67727.1 481 LPS-binding protein [Mus musculus]
GI:113865991 GenBank AAH04795.1 481 Lbp protein [Mus musculus]
GI:113865991 GenBank AAI01907.1 481 Lipopolysaccharide binding protein [Rattus norvegicus]
GI:113865991 PDB 4M4D 467 Chain A, Crystal Structure Of Lipopolysaccharide Binding Protein
GI:113865991 PDB 4M4D 467 Chain B, Crystal Structure Of Lipopolysaccharide Binding Protein
GI:113865991 RefSeq NP_058904.2 481 lipopolysaccharide-binding protein precursor [Rattus norvegicus]