Gene/Proteome Database (LMPD)

LMPD ID
LMP001751
Gene ID
Species
Mus musculus (Mouse)
Gene Name
glutaryl-Coenzyme A dehydrogenase
Gene Symbol
Synonyms
9030411L18; AI266902; D17825; GCD
Alternate Names
glutaryl-CoA dehydrogenase, mitochondrial
Chromosome
8
Map Location
8 C3|8 41.28 cM
EC Number
1.3.8.6

Proteins

glutaryl-CoA dehydrogenase, mitochondrial
Refseq ID NP_032123
Protein GI 390190196
UniProt ID Q60759
mRNA ID NM_008097
Length 447
RefSeq Status VALIDATED
MVPAMLTGYMSLRGVSARLLSRRSGLRFPRFPRTWSSAAAHTEKTQIRPAKSSRPVFDWKDPLILEEQLTADEKLIRDTFRNYCQERLMSRILLANRNEVFHRDIVYEMGELGVLGPTIKGYGCAGVSSVAYGLLTRELERVDSGYRSMMSVQSSLVMHPIYTYGSEEQRQKYLPGLAKGELLGCFGLTEPNHGSDPGGMETRARHNPSNQSYTLSGTKTWITNSPVADLFIVWARCEDNCIRGFILEKGMRGLSAPRIEGKFSLRASATGMIIMDSVEVPEENVLPNVSSLAGPFGCLNTARYGITWGVLGAAEFCLHTARQYALDRIQFGVPLARNQLVQKKLADMLTEITLGLHACLQLGRLKDQDKATPEMVSMLKRNNCGKALDIARQARDILGGNGISDEYHVIRHAMNLEAVNTYEGTHDIHALILGRAITGIQAFTVGK
glutaryl-CoA dehydrogenase, mitochondrial
Refseq ID NP_001038209
Protein GI 390190197
UniProt ID Q8BVD4
mRNA ID NM_001044744
Length 447
RefSeq Status VALIDATED
Protein sequence is identical to GI:390190196 (mRNA isoform)

Gene Information

Entrez Gene ID
Gene Name
glutaryl-Coenzyme A dehydrogenase
Gene Symbol
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005743 IDA:MGI C mitochondrial inner membrane
GO:0005739 IDA:MGI C mitochondrion
GO:0003995 IEA:InterPro F acyl-CoA dehydrogenase activity
GO:0050660 IEA:InterPro F flavin adenine dinucleotide binding
GO:0006568 IEA:UniProtKB-UniPathway P tryptophan metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu00310 Lysine degradation
mmu00380 Tryptophan metabolism

Domain Information

InterPro Annotations

Accession Description
IPR006089 Acyl-CoA dehydrogenase, conserved site
IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain
IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain

UniProt Annotations

Entry Information

Gene Name
glutaryl-Coenzyme A dehydrogenase
Protein Entry
Q8BVD4_MOUSE
UniProt ID
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Glutaryl-CoA + electron-transfer flavoprotein = crotonyl-CoA + CO(2) + reduced electron-transfer flavoprotein.
Cofactor Name=FAD; Xref=ChEBI:CHEBI:57692;
Function Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor.
Pathway Amino-acid metabolism; lysine degradation.
Pathway Amino-acid metabolism; tryptophan metabolism.
Similarity Belongs to the acyl-CoA dehydrogenase family. {ECO:0000305}.
Subcellular Location Mitochondrion matrix.
Subunit Homotetramer.

Identical and Related Proteins

Unique RefSeq proteins for LMP001751 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
390190196 RefSeq NP_032123 447 glutaryl-CoA dehydrogenase, mitochondrial

Identical Sequences to LMP001751 proteins

Reference Database Accession Length Protein Name
GI:390190196 RefSeq NP_001038209.2 447 glutaryl-CoA dehydrogenase, mitochondrial [Mus musculus]

Related Sequences to LMP001751 proteins

Reference Database Accession Length Protein Name
GI:390190196 DBBJ BAE38166.1 438 unnamed protein product [Mus musculus]
GI:390190196 GenBank AAH61158.1 438 Glutaryl-Coenzyme A dehydrogenase [Mus musculus]
GI:390190196 GenBank EDL10967.1 454 glutaryl-Coenzyme A dehydrogenase, isoform CRA_a, partial [Mus musculus]
GI:390190196 GenBank EDL10968.1 447 glutaryl-Coenzyme A dehydrogenase, isoform CRA_b [Mus musculus]
GI:390190196 RefSeq NP_001102366.1 447 glutaryl-CoA dehydrogenase, mitochondrial [Rattus norvegicus]
GI:390190196 SwissProt Q60759.2 438 RecName: Full=Glutaryl-CoA dehydrogenase, mitochondrial; Short=GCD; Flags: Precursor [Mus musculus]