Gene/Proteome Database (LMPD)

LMPD ID
LMP001757
Gene ID
11997
Species
Mus musculus (Mouse)
Gene Name
aldo-keto reductase family 1, member B7
Gene Symbol
Akr1b7
Synonyms
AR; Avdp; MVDP
Alternate Names
aldose reductase-related protein 1; aldehyde reductase; androgen regulated vas deferens protein; vas deferens androgen-dependent protein
Chromosome
6
Map Location
6 B1|6 14.95 cM
EC Number
1.1.1.21

Proteins

aldose reductase-related protein 1
Refseq ID NP_033861
Protein GI 160415215
UniProt ID P21300
mRNA ID NM_009731
Length 316
RefSeq Status VALIDATED
MATFVELSTKAKMPLVGLGTWKSSPGQVKEAVKAAIDAGYRHIDCAYVYHNENEVGEAIQEKIKENAVKREDLFIVSKLWATFFEKSLVKKAFQNTLSDLKLDYLDLYLVHWPQGFQAGNALLPKDNKGKVLLSKSTFLDAWEAMEELVDQGLVKALGISNFNHFQIERLLNKPGLKHKPVTNQIESHPYLTQEKLIQYCQSKGIAVTAYSPLGSPDRPYAKPEDPVVMEIPKIKEIAAKHKKTVAQVLIRFHVQRNVVVIPKSVTPSRIQENLQVFDFQLSEEDMAAILSFNRNWRACDLLDARTEEDYPFHEEY

Gene Information

Entrez Gene ID
11997
Gene Name
aldo-keto reductase family 1, member B7
Gene Symbol
Akr1b7
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IDA:MGI C mitochondrion
GO:0004032 IEA:UniProtKB-EC F alditol:NADP+ 1-oxidoreductase activity
GO:0044255 TAS:MGI P cellular lipid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu00561 Glycerolipid metabolism
mmu01100 Metabolic pathways
mmu00040 Pentose and glucuronate interconversions

REACTOME Pathway Links

REACTOME Pathway ID Description
5893902 Retinoid metabolism and transport

Domain Information

InterPro Annotations

Accession Description
IPR001395 Aldo/keto reductase
IPR020471 Aldo/keto reductase subgroup
IPR018170 Aldo/keto reductase, conserved site
IPR023210 NADP-dependent oxidoreductase domain

UniProt Annotations

Entry Information

Gene Name
aldo-keto reductase family 1, member B7
Protein Entry
ALD1_MOUSE
UniProt ID
P21300
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Alditol + NAD(P)(+) = aldose + NAD(P)H.
Function Reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. May play a role in the metabolism of xenobiotic aromatic aldehydes (By similarity). The role of MVDP in sperm maturation and storage may be related to its potential capacity to produce fructose, or MVDP may play an osmoregulatory role by producing sorbitol. {ECO:0000250}.
Induction Castration resulted in a marked decrease in the level of the mRNA coding for the protein, whereas administration of testosterone to castrated males resulted in a marked increase.
Similarity Belongs to the aldo/keto reductase family. {ECO:0000305}.
Subcellular Location Cytoplasm {ECO:0000250}.
Subunit Monomer. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001757 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
160415215 RefSeq NP_033861 316 aldose reductase-related protein 1

Identical Sequences to LMP001757 proteins

Reference Database Accession Length Protein Name
GI:160415215 DBBJ BAB22299.1 316 unnamed protein product [Mus musculus]
GI:160415215 GenBank AAA39774.1 316 aldose reductase [Mus musculus domesticus]
GI:160415215 GenBank AAH86929.1 316 Aldo-keto reductase family 1, member B7 [Mus musculus]
GI:160415215 GenBank EDL13689.1 316 mCG6071 [Mus musculus]
GI:160415215 SwissProt P21300.4 316 RecName: Full=Aldose reductase-related protein 1; AltName: Full=Aldehyde reductase; Short=AR; AltName: Full=Aldo-keto reductase family 1 member B7; AltName: Full=MVDP; AltName: Full=Vas deferens androgen-dependent protein [Mus musculus]

Related Sequences to LMP001757 proteins

Reference Database Accession Length Protein Name
GI:160415215 DBBJ BAE28129.1 316 unnamed protein product [Mus musculus]
GI:160415215 EMBL CAZ67102.1 316 aldo-keto reductase 1-B7 [Meriones libycus]
GI:160415215 EMBL CAZ67103.1 316 aldo-keto reductase 1-B7 [Gerbillus gerbillus]
GI:160415215 GenBank AAA39773.1 316 vas deferens protein [Mus musculus]
GI:160415215 RefSeq XP_005365863.1 316 PREDICTED: aldose reductase-related protein 1-like [Microtus ochrogaster]
GI:160415215 RefSeq XP_007616243.1 316 PREDICTED: aldose reductase-related protein 1 [Cricetulus griseus]