Gene/Proteome Database (LMPD)

LMPD ID
LMP001770
Gene ID
3995
Species
Homo sapiens (Human)
Gene Name
fatty acid desaturase 3
Gene Symbol
FADS3
Synonyms
CYB5RP; LLCDL3
Alternate Names
fatty acid desaturase 3; delta-9-desaturase; cytochrome b5-related protein; delta-9 fatty acid desaturase; linoleoyl-CoA desaturase (delta-9-desaturase)-like 3
Chromosome
11
Map Location
11q12-q13.1
EC Number
1.14.19.-
Summary
The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for FADS3

Proteins

fatty acid desaturase 3
Refseq ID NP_068373
Protein GI 13375616
UniProt ID Q9Y5Q0
mRNA ID NM_021727
Length 445
RefSeq Status REVIEWED
MGGVGEPGPREGPAQPGAPLPTFCWEQIRAHDQPGDKWLVIERRVYDISRWAQRHPGGSRLIGHHGAEDATDAFRAFHQDLNFVRKFLQPLLIGELAPEEPSQDGPLNAQLVEDFRALHQAAEDMKLFDASPTFFAFLLGHILAMEVLAWLLIYLLGPGWVPSALAAFILAISQAQSWCLQHDLGHASIFKKSWWNHVAQKFVMGQLKGFSAHWWNFRHFQHHAKPNIFHKDPDVTVAPVFLLGESSVEYGKKKRRYLPYNQQHLYFFLIGPPLLTLVNFEVENLAYMLVCMQWADLLWAASFYARFFLSYLPFYGVPGVLLFFVAVRVLESHWFVWITQMNHIPKEIGHEKHRDWVSSQLAATCNVEPSLFTNWFSGHLNFQIEHHLFPRMPRHNYSRVAPLVKSLCAKHGLSYEVKPFLTALVDIVRSLKKSGDIWLDAYLHQ

Gene Information

Entrez Gene ID
3995
Gene Name
fatty acid desaturase 3
Gene Symbol
FADS3
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016020 NAS:UniProtKB C membrane
GO:0020037 IEA:InterPro F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0016717 IEA:InterPro F oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
GO:0006636 NAS:UniProtKB P unsaturated fatty acid biosynthetic process

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_121100 Linoleic acid (LA) metabolism
REACT_116145 PPARA activates gene expression
REACT_121284 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
REACT_121147 alpha-linolenic acid (ALA) metabolism

Domain Information

InterPro Annotations

Accession Description
IPR001199 Cytochrome b5-like heme/steroid binding domain
IPR005804 Fatty acid desaturase, type 1
IPR012171 Fatty acid/sphingolipid desaturase

UniProt Annotations

Entry Information

Gene Name
fatty acid desaturase 3
Protein Entry
FADS3_HUMAN
UniProt ID
Q9Y5Q0
Species
Human

Comments

Comment Type Description
Domain The histidine box domains may contain the active site and/or be involved in metal ion binding.
Sequence Caution Sequence=AAC23396.1; Type=Erroneous gene model prediction; Evidence= ;
Similarity Belongs to the fatty acid desaturase family.
Similarity Contains 1 cytochrome b5 heme-binding domain.
Subcellular Location Endoplasmic reticulum membrane {ECO
Tissue Specificity Has been found in heart, liver, lung, uterus, and brainstem.

Identical and Related Proteins

Unique RefSeq proteins for LMP001770 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13375616 RefSeq NP_068373 445 fatty acid desaturase 3

Identical Sequences to LMP001770 proteins

Reference Database Accession Length Protein Name
GI:13375616 GenBank JAA09368.1 445 fatty acid desaturase 3 [Pan troglodytes]
GI:13375616 GenBank JAA16191.1 445 fatty acid desaturase 3 [Pan troglodytes]
GI:13375616 GenBank JAA30786.1 445 fatty acid desaturase 3 [Pan troglodytes]
GI:13375616 GenBank JAA41519.1 445 fatty acid desaturase 3 [Pan troglodytes]
GI:13375616 GenBank AIC54705.1 445 FADS3, partial [synthetic construct]
GI:13375616 RefSeq XP_003828508.1 445 PREDICTED: fatty acid desaturase 3 isoform X2 [Pan paniscus]

Related Sequences to LMP001770 proteins

Reference Database Accession Length Protein Name
GI:13375616 GenBank AFI35623.1 445 fatty acid desaturase 3 [Macaca mulatta]
GI:13375616 RefSeq NP_001138558.1 445 fatty acid desaturase 3 [Papio anubis]
GI:13375616 RefSeq XP_007994023.1 445 PREDICTED: fatty acid desaturase 3 [Chlorocebus sabaeus]
GI:13375616 RefSeq XP_008952129.1 454 PREDICTED: fatty acid desaturase 3 isoform X1 [Pan paniscus]
GI:13375616 RefSeq XP_009421526.1 454 PREDICTED: fatty acid desaturase 3 isoform X1 [Pan troglodytes]
GI:13375616 RefSeq XP_010383223.1 445 PREDICTED: fatty acid desaturase 3 isoform X1 [Rhinopithecus roxellana]