Gene/Proteome Database (LMPD)
LMPD ID
LMP001778
Gene ID
Species
Homo sapiens (Human)
Gene Name
protein kinase D2
Gene Symbol
Synonyms
PKD2; nPKC-D2
Chromosome
19
Map Location
19q13.3
Summary
The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| serine/threonine-protein kinase D2 isoform A | |
|---|---|
| Refseq ID | NP_001073349 |
| Protein GI | 120659782 |
| UniProt ID | Q9BZL6 |
| mRNA ID | NM_001079880 |
| Length | 878 |
| RefSeq Status | REVIEWED |
| MATAPSYPAGLPGSPGPGSPPPPGGLELQSPPPLLPQIPAPGSGVSFHIQIGLTREFVLLPAASELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTSANLLQLVRSSGDIQEGDLVEVVLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPCTAEELSRSTTELLPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADKSALMDESEDSGVIPGSHSENALHASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSLVPPGTNPHCFEIVTANATYFVGEMPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELEGKMGERYITHESDDARWEQFAAEHPLPGSGLPTDRDLGGACPPQDHDMQGLAERISVL | |
| serine/threonine-protein kinase D2 isoform A | |
|---|---|
| Refseq ID | NP_001073350 |
| Protein GI | 120659785 |
| UniProt ID | Q9BZL6 |
| mRNA ID | NM_001079881 |
| Length | 878 |
| RefSeq Status | REVIEWED |
| Protein sequence is identical to GI:120659782 (mRNA isoform) | |
| serine/threonine-protein kinase D2 isoform A | |
|---|---|
| Refseq ID | NP_057541 |
| Protein GI | 19923468 |
| UniProt ID | Q9BZL6 |
| mRNA ID | NM_016457 |
| Length | 878 |
| RefSeq Status | REVIEWED |
| Protein sequence is identical to GI:120659782 (mRNA isoform) | |
| serine/threonine-protein kinase D2 isoform B | |
|---|---|
| Refseq ID | NP_001073351 |
| Protein GI | 120659787 |
| UniProt ID | Q8NCK8 |
| mRNA ID | NM_001079882 |
| Length | 721 |
| RefSeq Status | REVIEWED |
| MLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPCTAEELSRSTTELLPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADKSALMDESEDSGVIPGSHSENALHASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSLVPPGTNPHCFEIVTANATYFVGEMPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELEGKMGERYITHESDDARWEQFAAEHPLPGSGLPTDRDLGGACPPQDHDMQGLAERISVL | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
| GO:0046872 | IEA:UniProtKB-KW | F | metal ion binding |
| GO:0004697 | IEA:InterPro | F | protein kinase C activity |
| GO:0035556 | IEA:InterPro | P | intracellular signal transduction |
| GO:2000573 | IEA:Ensembl | P | positive regulation of DNA biosynthetic process |
| GO:0070374 | IEA:Ensembl | P | positive regulation of ERK1 and ERK2 cascade |
| GO:0050862 | IEA:Ensembl | P | positive regulation of T cell receptor signaling pathway |
| GO:0032743 | IEA:Ensembl | P | positive regulation of interleukin-2 production |
KEGG Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR020454 | Diacylglycerol/phorbol-ester binding |
| IPR001849 | Pleckstrin homology domain |
| IPR011993 | Pleckstrin homology-like domain |
| IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
| IPR000719 | Protein kinase domain |
| IPR017441 | Protein kinase, ATP binding site |
| IPR011009 | Protein kinase-like domain |
| IPR015727 | Protein_Kinase_C_mu-related |
| IPR008271 | Serine/threonine-protein kinase, active site |
| IPR002290 | Serine/threonine/dual specificity protein kinase, catalytic domain |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | ATP + a protein = ADP + a phosphoprotein. |
| Similarity | Contains 1 PH domain. |
| Similarity | Contains PH domain. |
| Similarity | Contains protein kinase domain. |
Identical and Related Proteins
Unique RefSeq proteins for LMP001778 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 120659782 | RefSeq | NP_001073349 | 878 | serine/threonine-protein kinase D2 isoform A |
| 120659787 | RefSeq | NP_001073351 | 721 | serine/threonine-protein kinase D2 isoform B |
Identical Sequences to LMP001778 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:120659787 | DBBJ | BAC11127.1 | 721 | unnamed protein product [Homo sapiens] |
| GI:120659787 | DBBJ | BAG53158.1 | 721 | unnamed protein product [Homo sapiens] |
| GI:120659787 | EMBL | CAF86729.1 | 721 | unnamed protein product [Homo sapiens] |
| GI:120659782 | GenBank | AAV26699.1 | 878 | Sequence 2 from patent US 6780626 |
| GI:120659782 | GenBank | ABA65335.1 | 878 | Sequence 2 from patent US 6942983 |
| GI:120659782 | GenBank | EAW57441.1 | 878 | protein kinase D2 [Homo sapiens] |
| GI:120659782 | GenBank | AAI56947.1 | 878 | Protein kinase D2 [synthetic construct] |
| GI:120659782 | GenBank | AAI56074.1 | 878 | Protein kinase D2, partial [synthetic construct] |
| GI:120659782 | RefSeq | NP_001073350.1 | 878 | serine/threonine-protein kinase D2 isoform A [Homo sapiens] |
| GI:120659787 | RefSeq | XP_005258773.2 | 721 | PREDICTED: serine/threonine-protein kinase D2 isoform X2 [Homo sapiens] |
Related Sequences to LMP001778 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:120659782 | DBBJ | BAG62084.1 | 888 | unnamed protein product [Homo sapiens] |
| GI:120659787 | GenBank | AAP02193.1 | 878 | Sequence 2 from patent US 6528294 |
| GI:120659787 | GenBank | AAV26699.1 | 878 | Sequence 2 from patent US 6780626 |
| GI:120659787 | GenBank | ABA65335.1 | 878 | Sequence 2 from patent US 6942983 |
| GI:120659787 | GenBank | EAW57441.1 | 878 | protein kinase D2 [Homo sapiens] |
| GI:120659782 | GenBank | AFK96103.1 | 878 | Sequence 131 from patent US 8153598 |
| GI:120659787 | RefSeq | NP_001073349.1 | 878 | serine/threonine-protein kinase D2 isoform A [Homo sapiens] |
| GI:120659787 | RefSeq | NP_001073350.1 | 878 | serine/threonine-protein kinase D2 isoform A [Homo sapiens] |
| GI:120659782 | RefSeq | XP_007995496.1 | 878 | PREDICTED: serine/threonine-protein kinase D2 [Chlorocebus sabaeus] |
| GI:120659782 | RefSeq | XP_007995497.1 | 878 | PREDICTED: serine/threonine-protein kinase D2 [Chlorocebus sabaeus] |
| GI:120659782 | RefSeq | XP_007995498.1 | 878 | PREDICTED: serine/threonine-protein kinase D2 [Chlorocebus sabaeus] |
| GI:120659782 | SwissProt | Q9BZL6.2 | 878 | RecName: Full=Serine/threonine-protein kinase D2; AltName: Full=nPKC-D2 [Homo sapiens] |