Gene/Proteome Database (LMPD)

LMPD ID
LMP001780
Gene ID
1588
Species
Homo sapiens (Human)
Gene Name
cytochrome P450, family 19, subfamily A, polypeptide 1
Gene Symbol
CYP19A1
Synonyms
ARO; ARO1; CPV1; CYAR; CYP19; CYPXIX; P-450AROM
Alternate Names
aromatase; estrogen synthase; estrogen synthetase; cytochrome P-450AROM; cytochrome P450 19A1; microsomal monooxygenase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily XIX (aromatization of androgens)
Chromosome
15
Map Location
15q21.1
EC Number
1.14.14.14
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Orthologs
View orthologs and multiple alignments for CYP19A1

Proteins

aromatase
Refseq ID NP_000094
Protein GI 13904858
UniProt ID Q8TCA4
mRNA ID NM_000103
Length 503
RefSeq Status REVIEWED
MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFTPRNSDRCLEH
aromatase
Refseq ID NP_112503
Protein GI 13904860
UniProt ID Q8TCA4
mRNA ID NM_031226
Length 503
RefSeq Status REVIEWED
Protein sequence is identical to GI:13904858 (mRNA isoform)

Gene Information

Entrez Gene ID
1588
Gene Name
cytochrome P450, family 19, subfamily A, polypeptide 1
Gene Symbol
CYP19A1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:LIFEdb C endoplasmic reticulum
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0016020 TAS:ProtInc C membrane
GO:0070330 IDA:UniProtKB F aromatase activity
GO:0009055 TAS:UniProtKB F electron carrier activity
GO:0020037 IDA:UniProtKB F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0016712 TAS:UniProtKB F oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0019825 TAS:ProtInc F oxygen binding
GO:0008209 IEA:Ensembl P androgen metabolic process
GO:0006703 TAS:Reactome P estrogen biosynthetic process
GO:0060736 IEA:Ensembl P prostate gland growth
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0006694 TAS:ProtInc P steroid biosynthetic process
GO:0008202 TAS:Reactome P steroid metabolic process
GO:0016125 TAS:Reactome P sterol metabolic process
GO:0006805 TAS:Reactome P xenobiotic metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa04913 Ovarian steroidogenesis
hsa00140 Steroid hormone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR017972 Cytochrome P450, conserved site

UniProt Annotations

Entry Information

Gene Name
cytochrome P450, family 19, subfamily A, polypeptide 1
Protein Entry
CP19A_HUMAN
UniProt ID
Q8TCA4
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P11511-1; Sequence=Displayed; Name=2; IsoId=P11511-2; Sequence=VSP_055583, VSP_055584; Note=No experimental confirmation available.;
Catalytic Activity Androst-4-ene-3,17-dione + 3 O(2) + 3 reduced flavoproteins = estrone + formate + 4 H(2)O + 3 oxidized flavoproteins.
Catalytic Activity Testosterone + 3 O(2) + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H(2)O + 3 oxidized flavoproteins.
Cofactor Name=heme; Xref=ChEBI
Disease Aromatase deficiency (AROD) [MIM
Disease Aromatase excess syndrome (AEXS) [MIM
Function Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Similarity Belongs to the cytochrome P450 family.
Subcellular Location Membrane; Peripheral membrane protein.
Tissue Specificity Brain, placenta and gonads. {ECO
Web Resource Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cyp19a1/";
Web Resource Name=Wikipedia; Note=Aromatase entry; URL="http://en.wikipedia.org/wiki/Aromatase";

Identical and Related Proteins

Unique RefSeq proteins for LMP001780 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13904858 RefSeq NP_000094 503 aromatase

Identical Sequences to LMP001780 proteins

Reference Database Accession Length Protein Name
GI:13904858 GenBank AHD72607.1 503 Sequence 9675 from patent US 8586006
GI:13904858 GenBank AHD72608.1 503 Sequence 9676 from patent US 8586006
GI:13904858 PDB 4GL5 503 Chain A, Structure Of Human Placental Aromatase Complexed With Designed Inhibitor Hddg029 (Compound 4)
GI:13904858 PDB 4GL7 503 Chain A, Structure Of Human Placental Aromatase Complexed With Designed Inhibitor Hddg046 (Compound 5)
GI:13904858 RefSeq XP_005254247.1 503 PREDICTED: aromatase isoform X1 [Homo sapiens]
GI:13904858 RefSeq XP_005254248.1 503 PREDICTED: aromatase isoform X2 [Homo sapiens]

Related Sequences to LMP001780 proteins

Reference Database Accession Length Protein Name
GI:13904858 EMBL CAA31929.1 503 unnamed protein product [Homo sapiens]
GI:13904858 GenBank AAA35557.1 503 aromatase precursor (EC 1.14.14.1) [Homo sapiens]
GI:13904858 GenBank ACM85103.1 512 Sequence 10601 from patent US 6812339
GI:13904858 RefSeq XP_004056230.1 503 PREDICTED: cytochrome P450 19A1-like isoform 1 [Gorilla gorilla gorilla]
GI:13904858 RefSeq XP_004056231.1 503 PREDICTED: cytochrome P450 19A1-like isoform 2 [Gorilla gorilla gorilla]
GI:13904858 RefSeq XP_009427400.1 503 PREDICTED: aromatase [Pan troglodytes]