Gene/Proteome Database (LMPD)

LMPD ID
LMP001787
Gene ID
1056
Species
Homo sapiens (Human)
Gene Name
carboxyl ester lipase
Gene Symbol
CEL
Synonyms
BAL; BSDL; BSSL; CELL; CEase; FAP; FAPP; LIPA; MODY8
Chromosome
9
Map Location
9q34.3
Summary
The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for CEL

Proteins

bile salt-activated lipase precursor
Refseq ID NP_001798
Protein GI 148536848
UniProt ID X6R868
mRNA ID NM_001807
Length 756
RefSeq Status REVIEWED
MLTMGRLQLVVLGLTCCWAVASAAKLGAVYTEGGFVEGVNKKLGLLGDSVDIFKGIPFAAPTKALENPQPHPGWQGTLKAKNFKKRCLQATITQDSTYGDEDCLYLNIWVPQGRKQVSRDLPVMIWIYGGAFLMGSGHGANFLNNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPWVIQKNPLFWAKKVAEKVGCPVGDAARMAQCLKVTDPRALTLAYKVPLAGLEYPMLHYVGFVPVIDGDFIPADPINLYANAADIDYIAGTNNMDGHIFASIDMPAINKGNKKVTEEDFYKLVSEFTITKGLRGAKTTFDVYTESWAQDPSQENKKKTVVDFETDVLFLVPTEIALAQHRANAKSAKTYAYLFSHPSRMPVYPKWVGADHADDIQYVFGKPFATPTGYRPQDRTVSKAMIAYWTNFAKTGDPNMGDSAVPTHWEPYTTENSGYLEITKKMGSSSMKRSLRTNFLRYWTLTYLALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPAVIRF
sig_peptide: 1..23 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2437 peptide sequence: MLTMGRLQLVVLGLTCCWAVASA

Gene Information

Entrez Gene ID
1056
Gene Name
carboxyl ester lipase
Gene Symbol
CEL
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016787 IEA:UniProtKB-KW F hydrolase activity

KEGG Pathway Links

KEGG Pathway ID Description
hsa04975 Fat digestion and absorption
hsa04972 Pancreatic secretion

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_9518 Digestion of dietary lipid

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR019826 Carboxylesterase type B, active site
IPR002018 Carboxylesterase, type B

UniProt Annotations

Entry Information

Gene Name
carboxyl ester lipase
Protein Entry
B4DSX9_HUMAN
UniProt ID
X6R868
Species
Human

Identical and Related Proteins

Unique RefSeq proteins for LMP001787 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
148536848 RefSeq NP_001798 756 bile salt-activated lipase precursor

Identical Sequences to LMP001787 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP001787 proteins

Reference Database Accession Length Protein Name
GI:148536848 GenBank AAC26514.1 745 carboxyl ester lipase [Homo sapiens]
GI:148536848 GenBank AAE13239.1 745 Sequence 2 from patent US 5827683
GI:148536848 GenBank ACM84349.1 759 Sequence 9847 from patent US 6812339
GI:148536848 GenBank ADS30697.1 745 Sequence 1229 from patent US 7781168
GI:148536848 pat US 745 Sequence 2 from patent US 5763739
GI:148536848 SwissProt P19835.3 753 RecName: Full=Bile salt-activated lipase; Short=BAL; AltName: Full=Bile salt-stimulated lipase; Short=BSSL; AltName: Full=Bucelipase; AltName: Full=Carboxyl ester lipase; AltName: Full=Cholesterol esterase; AltName: Full=Pancreatic lysophospholipase; AltName: Full=Sterol esterase; Flags: Precursor [Homo sapiens]