Gene/Proteome Database (LMPD)

LMPD ID
LMP001795
Gene ID
81579
Species
Homo sapiens (Human)
Gene Name
phospholipase A2, group XIIA
Gene Symbol
PLA2G12A
Synonyms
GXII; PLA2G12; ROSSY
Chromosome
4
Map Location
4q25
Summary
Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000 [PubMed 11031251]).[supplied by OMIM, Mar 2008]
Orthologs
View orthologs and multiple alignments for PLA2G12A

Proteins

group XIIA secretory phospholipase A2 precursor
Refseq ID NP_110448
Protein GI 21361944
UniProt ID Q542Y6
mRNA ID NM_030821
Length 189
RefSeq Status VALIDATED
MALLSRPALTLLLLLMAAVVRCQEQAQTTDWRATLKTIRNGVHKIDTYLNAALDLLGGEDGLCQYKCSDGSKPFPRYGYKPSPPNGCGSPLFGVHLNIGIPSLTKCCNQHDRCYETCGKSKNDCDEEFQYCLSKICRDVQKTLGLTQHVQACETTVELLFDSVIHLGCKPYLDSQRAACRCHYEEKTDL
sig_peptide: 1..22 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2369 peptide sequence: MALLSRPALTLLLLLMAAVVRC mat_peptide: 23..189 product: Group XIIA secretory phospholipase A2 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9BZM1.1) calculated_mol_wt: 18716 peptide sequence: QEQAQTTDWRATLKTIRNGVHKIDTYLNAALDLLGGEDGLCQYKCSDGSKPFPRYGYKPSPPNGCGSPLFGVHLNIGIPSLTKCCNQHDRCYETCGKSKNDCDEEFQYCLSKICRDVQKTLGLTQHVQACETTVELLFDSVIHLGCKPYLDSQRAACRCHYEEKTDL

Gene Information

Entrez Gene ID
81579
Gene Name
phospholipase A2, group XIIA
Gene Symbol
PLA2G12A
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:Ensembl C Golgi apparatus
GO:0005783 IEA:Ensembl C endoplasmic reticulum
GO:0005576 IEA:InterPro C extracellular region
GO:0005509 IEA:InterPro F calcium ion binding
GO:0004623 IEA:Ensembl F phospholipase A2 activity
GO:0016042 IEA:InterPro P lipid catabolic process
GO:0006644 IEA:InterPro P phospholipid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa04975 Fat digestion and absorption
hsa04972 Pancreatic secretion
hsa04014 Ras signaling pathway
hsa04270 Vascular smooth muscle contraction

Domain Information

InterPro Annotations

Accession Description
IPR016090 Phospholipase A2 domain
IPR013090 Phospholipase A2, active site
IPR010711 Phospholipase A2, group XII secretory

UniProt Annotations

Entry Information

Gene Name
phospholipase A2, group XIIA
Protein Entry
PG12A_HUMAN
UniProt ID
Q542Y6
Species
Human

Identical and Related Proteins

Unique RefSeq proteins for LMP001795 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
21361944 RefSeq NP_110448 189 group XIIA secretory phospholipase A2 precursor

Identical Sequences to LMP001795 proteins

Reference Database Accession Length Protein Name
GI:21361944 GenBank JAA37068.1 189 phospholipase A2, group XIIA [Pan troglodytes]
GI:21361944 GenBank JAA37069.1 189 phospholipase A2, group XIIA [Pan troglodytes]
GI:21361944 GenBank AGF22445.1 189 Sequence 11 from patent US 8372594
GI:21361944 GenBank AHD74341.1 189 Sequence 13707 from patent US 8586006
GI:21361944 GenBank AIC52430.1 189 PLA2G12A, partial [synthetic construct]
GI:21361944 RefSeq XP_004040321.1 189 PREDICTED: group XIIA secretory phospholipase A2 [Gorilla gorilla gorilla]

Related Sequences to LMP001795 proteins

Reference Database Accession Length Protein Name
GI:21361944 GenBank ABJ27864.1 189 Sequence 108 from patent US 7091315
GI:21361944 GenBank ABJ27956.1 237 Sequence 200 from patent US 7091315
GI:21361944 GenBank ACE20430.1 189 Sequence 5660 from patent US 7368531
GI:21361944 GenBank AEF65377.1 189 Sequence 108 from patent US 7932361
GI:21361944 GenBank AEF65469.1 237 Sequence 200 from patent US 7932361
GI:21361944 RefSeq XP_003269406.1 189 PREDICTED: group XIIA secretory phospholipase A2 [Nomascus leucogenys]