Gene/Proteome Database (LMPD)
LMPD ID
LMP001799
Gene ID
Species
Mus musculus (Mouse)
Gene Name
acyl-Coenzyme A oxidase 2, branched chain
Gene Symbol
Synonyms
THCCox
Alternate Names
peroxisomal acyl-coenzyme A oxidase 2; THCA-CoA oxidase; branched chain acyl-CoA oxidase; trihydroxycoprostanoyl-CoA oxidase; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase
Chromosome
14
Map Location
14 A1|14
EC Number
1.17.99.3
Proteins
| peroxisomal acyl-coenzyme A oxidase 2 | |
|---|---|
| Refseq ID | NP_444345 |
| Protein GI | 239787088 |
| UniProt ID | Q9QXD1 |
| mRNA ID | NM_053115 |
| Length | 681 |
| RefSeq Status | VALIDATED |
| MGNPGDRVSLGETWSREVHPDIDSERHSPSFSVERLTNILDGGIPNTELRRRVESLIQRDPVFNLKHLYFMTRDELYEDAVQKRFHLEKLAWSLGWSEDGPERIYADRVLAGYNNLNLHGIAMNAIRSLGSDEQIAKWGQLGKNFQIITTYAQTELGHGTYLQGLETEATYDATTQEFVIHSPTMTSIKWWPGDLGRTVTHAVVLAHLICLGARHGMHAFIVPIRSLEDHTPLPGITVGDIGPKMGFENIDNGFLRLNHVRVPRENMLSRFAEVLPDGTYQRLGTPQSNYLGMLVTRVQLLYKGFLPTLQKACTIAVRYAVIRHQSRLRPSDPEAKILEYQTQQQKLLPQLAVSYALHFMTTSLLQFFHSSYSDILKRDFSLLPELHALSTGMKAMSSDFCAQGTEICRRACGGHGYSKLSGLPTLVTQAIASCTYEGENTVLYLQVARFLMKSYLQAQVSPGSIPQKPLPQSVMYLATPRPARCPAQTAADFRCPEVYTTAWAYVSARLIRDATQHTQTLMRSGVDQYDAWNQTSVIHLQAAKAHCYFLTVRNFKEAVEKLDNEPEIQRVLQNLCDLYALNGILTNSGDFLHDGFLSGAQVDMARTAFLDLLPLIRKDAILLTDAFDFSDHCLNSALGCYDGHVYQRLFEWAQKSPANTQENPAYKKYIRPLMQSWKPKL | |
| peroxisomal acyl-coenzyme A oxidase 2 | |
|---|---|
| Refseq ID | NP_001155139 |
| Protein GI | 239787090 |
| UniProt ID | Q9QXD1 |
| mRNA ID | NM_001161667 |
| Length | 681 |
| RefSeq Status | VALIDATED |
| Protein sequence is identical to GI:239787088 (mRNA isoform) | |
Gene Information
Entrez Gene ID
Gene Name
acyl-Coenzyme A oxidase 2, branched chain
Gene Symbol
Species
Mus musculus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005777 | IEA:UniProtKB-KW | C | peroxisome |
| GO:0033791 | IEA:UniProtKB-EC | F | 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity |
| GO:0003995 | IEA:InterPro | F | acyl-CoA dehydrogenase activity |
| GO:0003997 | IEA:InterPro | F | acyl-CoA oxidase activity |
| GO:0050660 | IEA:InterPro | F | flavin adenine dinucleotide binding |
| GO:0006635 | IEA:InterPro | P | fatty acid beta-oxidation |
KEGG Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR009075 | Acyl-CoA dehydrogenase/oxidase C-terminal |
| IPR013786 | Acyl-CoA dehydrogenase/oxidase, N-terminal |
| IPR009100 | Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain |
| IPR012258 | Acyl-CoA oxidase |
| IPR002655 | Acyl-CoA oxidase, C-terminal |
| IPR006091 | Acyl-CoA oxidase/dehydrogenase, central domain |
| IPR029320 | Acyl-coenzyme A oxidase, N-terminal |
UniProt Annotations
Entry Information
Gene Name
acyl-Coenzyme A oxidase 2, branched chain
Protein Entry
ACOX2_MOUSE
UniProt ID
Species
Mouse
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | (25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5- beta-cholestan-26-oyl-CoA + H(2)O + acceptor = (24R,25R)-3- alpha,7-alpha,12-alpha,24-tetrahydroxy-5-beta-cholestan-26-oyl-CoA + reduced acceptor. |
| Cofactor | Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250}; |
| Function | Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycoprostanic acids. {ECO:0000250}. |
| Ptm | Acetylation of Lys-667 is observed in liver mitochondria from fasted mice but not from fed mice. |
| Similarity | Belongs to the acyl-CoA oxidase family. {ECO:0000305}. |
| Subcellular Location | Peroxisome {ECO:0000250}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP001799 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 239787088 | RefSeq | NP_444345 | 681 | peroxisomal acyl-coenzyme A oxidase 2 |
Identical Sequences to LMP001799 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:239787088 | EMBL | CBU96012.1 | 681 | unnamed protein product [Mus musculus] |
| GI:239787088 | GenBank | AGX52689.1 | 681 | Sequence 5733 from patent US 8541208 |
| GI:239787088 | GenBank | AGX57626.1 | 681 | Sequence 15595 from patent US 8541208 |
| GI:239787088 | GenBank | AGX63410.1 | 681 | Sequence 26924 from patent US 8541208 |
| GI:239787088 | RefSeq | XP_006518171.1 | 681 | PREDICTED: peroxisomal acyl-coenzyme A oxidase 2 isoform X1 [Mus musculus] |
| GI:239787088 | SwissProt | Q9QXD1.2 | 681 | RecName: Full=Peroxisomal acyl-coenzyme A oxidase 2; AltName: Full=3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase; AltName: Full=3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase; AltName: Full=Trihydroxycoprostanoyl-CoA oxidase; Short=THCA-CoA oxidase; Short=THCCox [Mus musculus] |
Related Sequences to LMP001799 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:239787088 | DBBJ | BAE25794.1 | 681 | unnamed protein product [Mus musculus] |
| GI:239787088 | EMBL | CAB65251.1 | 681 | branched chain acyl-CoA oxidase [Mus musculus] |
| GI:239787088 | GenBank | EDL20586.1 | 675 | acyl-Coenzyme A oxidase 2, branched chain, isoform CRA_a [Mus musculus] |
| GI:239787088 | GenBank | EDL20587.1 | 731 | acyl-Coenzyme A oxidase 2, branched chain, isoform CRA_b, partial [Mus musculus] |
| GI:239787088 | GenBank | EDL20588.1 | 744 | acyl-Coenzyme A oxidase 2, branched chain, isoform CRA_c, partial [Mus musculus] |
| GI:239787088 | RefSeq | XP_006518172.1 | 628 | PREDICTED: peroxisomal acyl-coenzyme A oxidase 2 isoform X2 [Mus musculus] |