Gene/Proteome Database (LMPD)
LMPD ID
LMP001808
Gene ID
Species
Homo sapiens (Human)
Gene Name
oxysterol binding protein
Gene Symbol
Synonyms
OSBP1
Alternate Names
oxysterol-binding protein 1
Chromosome
11
Map Location
11q12-q13
Summary
Oxysterol binding protein is an intracellular protein that is believed to transport sterols from lysosomes to the nucleus where the sterol down-regulates the genes for the LDL receptor, HMG-CoA reductase, and HMG synthetase [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| oxysterol-binding protein 1 | |
|---|---|
| Refseq ID | NP_002547 |
| Protein GI | 4505531 |
| UniProt ID | P22059 |
| mRNA ID | NM_002556 |
| Length | 807 |
| RefSeq Status | REVIEWED |
| MAATELRGVVGPGPAAIAALGGGGAGPPVVGGGGGRGDAGPGSGAASGTVVAAAAGGPGPGAGGVAAAGPAPAPPTGGSGGSGAGGSGSAREGWLFKWTNYIKGYQRRWFVLSNGLLSYYRSKAEMRHTCRGTINLATANITVEDSCNFIISNGGAQTYHLKASSEVERQRWVTALELAKAKAVKMLAESDESGDEESVSQTDKTELQNTLRTLSSKVEDLSTCNDLIAKHGTALQRSLSELESLKLPAESNEKIKQVNERATLFRITSNAMINACRDFLMLAQTHSKKWQKSLQYERDQRIRLEETLEQLAKQHNHLERAFRGATVLPANTPGNVGSGKDQCCSGKGDMSDEDDENEFFDAPEIITMPENLGHKRTGSNISGASSDISLDEQYKHQLEETKKEKRTRIPYKPNYSLNLWSIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDLEYHELLDRAAKCENSLEQLCYVAAFTVSSYSTTVFRTSKPFNPLLGETFELDRLEENGYRSLCEQVSHHPPAAAHHAESKNGWTLRQEIKITSKFRGKYLSIMPLGTIHCIFHATGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDIVNHKTGDKCNLKFVPYSYFSRDVARKVTGEVTDPSGKVHFALLGTWDEKMECFKVQPVIGENGGDARQRGHEAEESRVMLWKRNPLPKNAENMYYFSELALTLNAWESGTAPTDSRLRPDQRLMENGRWDEANAEKQRLEEKQRLSRKKREAEAMKATEDGTPYDPYKALWFERKKDPVTKELTHIYRGEYWECKEKQDWSSCPDIF | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005794 | IDA:HPA | C | Golgi apparatus |
| GO:0030054 | IDA:HPA | C | cell junction |
| GO:0005737 | IDA:HPA | C | cytoplasm |
| GO:0016020 | IEA:UniProtKB-KW | C | membrane |
| GO:0005730 | IDA:HPA | C | nucleolus |
| GO:0005634 | IDA:HPA | C | nucleus |
| GO:0008142 | TAS:ProtInc | F | oxysterol binding |
| GO:0006869 | IEA:UniProtKB-KW | P | lipid transport |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_111217 | Metabolism |
| REACT_22258 | Metabolism of lipids and lipoproteins |
| REACT_115810 | Sphingolipid de novo biosynthesis |
| REACT_19323 | Sphingolipid metabolism |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Domain | The PH and Ala/Gly-rich domains control cholesterol binding without affecting 25-hydroxycholesterol binding. |
| Domain | The second coiled-coil domain is required for interaction with the tyrosine phosphatase. |
| Function | Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25- hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability. |
| Interaction | O75344:FKBP6; NbExp=2; IntAct=EBI-2681902, EBI-744771; |
| Sequence Caution | Sequence=AAH63121.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence= ; |
| Similarity | Belongs to the OSBP family. |
| Similarity | Contains 1 PH domain. {ECO |
| Subcellular Location | Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Note=When bound to oxysterols, translocates to the periphery of Golgi membranes. |
| Subunit | Homodimer or homotrimer. Interacts with VAPA. |
| Tissue Specificity | Widely expressed. |
Identical and Related Proteins
Unique RefSeq proteins for LMP001808 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 4505531 | RefSeq | NP_002547 | 807 | oxysterol-binding protein 1 |
Identical Sequences to LMP001808 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4505531 | GenBank | AAA59973.1 | 807 | oxysterol-binding protein [Homo sapiens] |
| GI:4505531 | GenBank | AAG17011.1 | 807 | oxysterol-binding protein 1 [Homo sapiens] |
| GI:4505531 | GenBank | AAG28373.1 | 807 | oxysterol binding protein 1 [Homo sapiens] |
| GI:4505531 | GenBank | AAH11581.1 | 807 | Oxysterol binding protein [Homo sapiens] |
| GI:4505531 | GenBank | EAW73849.1 | 807 | oxysterol binding protein [Homo sapiens] |
| GI:4505531 | GenBank | AHD74698.1 | 807 | Sequence 14715 from patent US 8586006 |
Related Sequences to LMP001808 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4505531 | GenBank | AFJ71525.1 | 805 | oxysterol-binding protein 1 [Macaca mulatta] |
| GI:4505531 | GenBank | JAA20141.1 | 807 | oxysterol binding protein [Pan troglodytes] |
| GI:4505531 | RefSeq | XP_508451.1 | 807 | PREDICTED: oxysterol-binding protein 1 isoform X1 [Pan troglodytes] |
| GI:4505531 | RefSeq | XP_002821783.1 | 808 | PREDICTED: oxysterol-binding protein 1 [Pongo abelii] |
| GI:4505531 | RefSeq | XP_003275246.1 | 807 | PREDICTED: oxysterol-binding protein 1 [Nomascus leucogenys] |
| GI:4505531 | RefSeq | NP_001253105.1 | 805 | oxysterol-binding protein 1 [Macaca mulatta] |