Gene/Proteome Database (LMPD)

LMPD ID
LMP001813
Gene ID
20442
Species
Mus musculus (Mouse)
Gene Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
Gene Symbol
St3gal1
Synonyms
5330418N22Rik; AI467004; ST3GalI; Siat4; Siat4a; St3gal-1
Alternate Names
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1; ST3O; SIAT4-A; ST3Gal I; ST3GalA.1; gal-NAc6S; alpha 2,3-ST 1; ST3GAL-I sialyltransferase; Gal beta1,3 GalNAc alpha2,3 sialyltransferase; beta-galactoside alpha-2,3-sialyltransferase 1; gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase; sialyltransferase 4A (beta-galactoside alpha-2,3-sialytransferase); sialyltransferase 4A (beta-galactosidase alpha-2,3-sialytransferase); CMP-N-acetylneuraminate: [beta-galactosidase alpha-2,3] sialytransferase
Chromosome
15
Map Location
15 D2|15
EC Number
2.4.99.4

Proteins

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
Refseq ID NP_033203
Protein GI 6677957
UniProt ID P54751
mRNA ID NM_009177
Length 337
RefSeq Status VALIDATED
MRRKTLKYLTFFLLFIFLTSFVLNYSNTGVPSAWFPKQMLLELSENFRRFIKSQPCTCRHCISQDKVSYWFDQRFNKTMQPLLTVHNALMEEDTYRWWLRLQRERKPNNLSDTVKELFRLVPGNVDPMLNKRLVGCRRCAVVGNSGNLKDSSYGPEIDSHDFVLRMNKAPTVGFEADVGSRTTHHLVYPESFRELGENVNMVLVPFKTTDLQWVISATTTGTITHTYVPVPPKIKVKQEKILIYHPAFIKYVFDNWLQGHGRYPSTGILSIIFSIHICDEVDLYGFGADSKGNWHHYWENNPSAGAFRKTGVHDGDFEYNITTTLAAINKIRIFKGR

Gene Information

Entrez Gene ID
20442
Gene Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
Gene Symbol
St3gal1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0030173 IEA:InterPro C integral component of Golgi membrane
GO:0003836 IDA:MGI F beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
GO:0006054 ISS:UniProtKB P N-acetylneuraminate metabolic process
GO:0006487 ISS:UniProtKB P protein N-linked glycosylation
GO:0006486 IDA:MGI P protein glycosylation
GO:0006468 IDA:MGI P protein phosphorylation
GO:0097503 ISS:UniProtKB P sialylation

KEGG Pathway Links

KEGG Pathway ID Description
mmu00533 Glycosaminoglycan biosynthesis - keratan sulfate
mmu00603 Glycosphingolipid biosynthesis - globo series
mmu00512 Mucin type O-Glycan biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5893854 Keratan sulfate biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR001675 Glycosyl transferase, family 29
IPR012163 Sialyltransferase

UniProt Annotations

Entry Information

Gene Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
Protein Entry
SIA4A_MOUSE
UniProt ID
P54751
Species
Mouse

Comments

Comment Type Description
Catalytic Activity CMP-N-acetylneuraminate + beta-D-galactosyl- 1,3-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N- acetylneuraminyl-2,3-beta-D-galactosyl-1,3-N-acetyl-alpha-D- galactosaminyl-R.
Function It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found on sugar chains O- linked to Thr or Ser and also as a terminal sequence on certain gangliosides. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values.
Pathway Protein modification; protein glycosylation.
Ptm The soluble form derives from the membrane form by proteolytic processing.
Similarity Belongs to the glycosyltransferase 29 family. {ECO:0000305}.
Subcellular Location Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane- bound form in trans cisternae of Golgi. Secreted into the body fluid.
Tissue Specificity Highly expressed in submaxillary gland and to a much lesser extent in liver, lung, kidney, heart and brain.
Web Resource Name=Functional Glycomics Gateway - GTase; Note=ST3Gal I; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_642";

Identical and Related Proteins

Unique RefSeq proteins for LMP001813 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6677957 RefSeq NP_033203 337 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

Identical Sequences to LMP001813 proteins

Reference Database Accession Length Protein Name
GI:6677957 GenBank EDL29390.1 337 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 [Mus musculus]
GI:6677957 GenBank AFG79796.1 337 Sequence 55 from patent US 8137928
GI:6677957 GenBank AFN90529.1 337 Sequence 52 from patent US 8198045
GI:6677957 RefSeq XP_006520726.1 337 PREDICTED: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1 [Mus musculus]
GI:6677957 RefSeq XP_006520727.1 337 PREDICTED: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X2 [Mus musculus]
GI:6677957 RefSeq XP_006520728.1 337 PREDICTED: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X3 [Mus musculus]

Related Sequences to LMP001813 proteins

Reference Database Accession Length Protein Name
GI:6677957 DBBJ BAE23767.1 337 unnamed protein product [Mus musculus]
GI:6677957 EMBL CAG44449.1 340 sialyltransferase ST3Gal-I [Rattus norvegicus]
GI:6677957 GenBank AFG79797.1 340 Sequence 56 from patent US 8137928
GI:6677957 GenBank AFN90530.1 340 Sequence 53 from patent US 8198045
GI:6677957 RefSeq NP_001013237.1 340 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 [Rattus norvegicus]
GI:6677957 RefSeq XP_006241771.1 340 PREDICTED: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1 [Rattus norvegicus]