Gene/Proteome Database (LMPD)

LMPD ID
LMP001823
Gene ID
56794
Species
Mus musculus (Mouse)
Gene Name
2-hydroxyacyl-CoA lyase 1
Gene Symbol
Hacl1
Synonyms
1600020H07Rik; Hpcl; Phyh2
Alternate Names
2-hydroxyacyl-CoA lyase 1; 2-HPCL; 2-hydroxyphytanoyl-CoA lyase; phytanoyl-CoA 2-hydroxylase 2
Chromosome
14
Map Location
14 B|14
EC Number
4.1.-.-

Proteins

2-hydroxyacyl-CoA lyase 1
Refseq ID NP_064359
Protein GI 31560355
UniProt ID Q9QXE0
mRNA ID NM_019975
Length 581
RefSeq Status VALIDATED
MPESNSAEGSDRSEEQVSGAKVIAQALKTQDVEYMFGVVGIPVTEIALAAQELGIKYIGMRNEQAACYAASAVGYLTGRPGVCLVVSGPGLIHALGGMANANMNCWPLIVIGGSSERNQEAMGAFQEFPQVEACRLYTKFSARPSTIELIPFIIEKAVRSSIYGRPGACYIDIPADFVTLQANVTSIKYKECCMPPPVSMAETSAVCAAASVLRDAKQPLLIIGKGAAYSHAEDSIRKLVEQCSLPFLPTPMGKGVVPDNHPNCVGAARSRALQSADVIVLFGARLNWILHFGLPPRYQADVKFIQIDICAEELGNNVRPSVILLGDIDAVSKQLLEQFDKTPWQCPPDSQWWKTLREKMKSNEAISKELASQKSLPMNYYTVFYHVQEQLPRDSFIVSEGANTMDIGRTMLQNCLPRHRLDAGSFGTMGVGLGFAIAAALVAKDRSPGQRVICVEGDSAFGFSGMEVETICRYNLPIILLVVNNNGIYQGFDADTWEKMLHFQEAATTVPPMCLLPNSHYEQVMTAFGGKGYFVRTPEELQHSLRQALQDTSKPCLLNIMIEPQSTRKAQDFHWLTRSNM

Gene Information

Entrez Gene ID
56794
Gene Name
2-hydroxyacyl-CoA lyase 1
Gene Symbol
Hacl1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005777 ISS:HGNC C peroxisome
GO:0016830 ISS:HGNC F carbon-carbon lyase activity
GO:0016829 IDA:MGI F lyase activity
GO:0000287 IEA:InterPro F magnesium ion binding
GO:0030976 ISS:HGNC F thiamine pyrophosphate binding
GO:0001561 ISS:HGNC P fatty acid alpha-oxidation
GO:0006629 IDA:MGI P lipid metabolic process
GO:0051259 IEA:Ensembl P protein oligomerization

KEGG Pathway Links

KEGG Pathway ID Description
ko04146 Peroxisome
mmu04146 Peroxisome

REACTOME Pathway Links

REACTOME Pathway ID Description
5893690 Alpha-oxidation of phytanate
5892980 Peroxisomal lipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR029035 DHS-like NAD/FAD-binding domain
IPR029061 Thiamin diphosphate-binding fold
IPR011766 Thiamine pyrophosphate enzyme, C-terminal TPP-binding
IPR012001 Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain
IPR012000 Thiamine pyrophosphate enzyme, central domain

UniProt Annotations

Entry Information

Gene Name
2-hydroxyacyl-CoA lyase 1
Protein Entry
HACL1_MOUSE
UniProt ID
Q9QXE0
Species
Mouse

Comments

Comment Type Description
Catalytic Activity 2-hydroxyphytanoyl-CoA = pristanal + formyl- CoA.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000250};
Cofactor Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence={ECO:0000250}; Note=Binds 1 thiamine pyrophosphate per subunit. {ECO:0000250};
Function Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde. {ECO:0000250}.
Pathway Lipid metabolism; fatty acid metabolism.
Similarity Belongs to the TPP enzyme family. {ECO:0000305}.
Subcellular Location Peroxisome {ECO:0000250}.
Subunit Homotetramer. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001823 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
31560355 RefSeq NP_064359 581 2-hydroxyacyl-CoA lyase 1

Identical Sequences to LMP001823 proteins

Reference Database Accession Length Protein Name
GI:31560355 DBBJ BAB24085.1 581 unnamed protein product [Mus musculus]
GI:31560355 DBBJ BAC31032.1 581 unnamed protein product [Mus musculus]
GI:31560355 DBBJ BAC34059.1 581 unnamed protein product [Mus musculus]
GI:31560355 GenBank AAH21360.1 581 2-hydroxyacyl-CoA lyase 1 [Mus musculus]
GI:31560355 SwissProt Q9QXE0.2 581 RecName: Full=2-hydroxyacyl-CoA lyase 1; AltName: Full=2-hydroxyphytanoyl-CoA lyase; Short=2-HPCL; AltName: Full=Phytanoyl-CoA 2-hydroxylase 2 [Mus musculus]

Related Sequences to LMP001823 proteins

Reference Database Accession Length Protein Name
GI:31560355 EMBL CAB65550.1 581 2-hydroxyphytanoyl-CoA lyase [Mus musculus]
GI:31560355 EMBL CAD56981.1 581 2-hydroxyphytanoyl-CoA lyase [Rattus norvegicus]
GI:31560355 GenBank EDL24815.1 587 2-hydroxyacyl-CoA lyase 1, partial [Mus musculus]
GI:31560355 RefSeq NP_445945.1 581 2-hydroxyacyl-CoA lyase 1 [Rattus norvegicus]
GI:31560355 RefSeq XP_006519383.1 572 PREDICTED: 2-hydroxyacyl-CoA lyase 1 isoform X1 [Mus musculus]
GI:31560355 RefSeq XP_006996307.1 581 PREDICTED: 2-hydroxyacyl-CoA lyase 1 [Peromyscus maniculatus bairdii]