Gene/Proteome Database (LMPD)

LMPD ID
LMP001830
Gene ID
5037
Species
Homo sapiens (Human)
Gene Name
phosphatidylethanolamine binding protein 1
Gene Symbol
PEBP1
Synonyms
HCNP; HCNPpp; HEL-210; HEL-S-34; PBP; PEBP; PEBP-1; RKIP
Chromosome
12
Map Location
12q24.23

Proteins

phosphatidylethanolamine-binding protein 1 preproprotein
Refseq ID NP_002558
Protein GI 4505621
UniProt ID P30086
mRNA ID NM_002567
Length 187
RefSeq Status VALIDATED
MPVDLSKWSGPLSLQEVDEQPQHPLHVTYAGAAVDELGKVLTPTQVKNRPTSISWDGLDSGKLYTLVLTDPDAPSRKDPKYREWHHFLVVNMKGNDISSGTVLSDYVGSGPPKGTGLHRYVWLVYEQDRPLKCDEPILSNRSGDHRGKFKVASFRKKYELRAPVAGTCYQAEWDDYVPKLYEQLSGK
mat_peptide: 2..12 product: Hippocampal cholinergic neurostimulating peptide experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P30086.3) calculated_mol_wt: 1198 peptide sequence: PVDLSKWSGPL

Gene Information

Entrez Gene ID
5037
Gene Name
phosphatidylethanolamine binding protein 1
Gene Symbol
PEBP1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0070062 IDA:UniProtKB C extracellular vesicular exosome
GO:0005634 IDA:UniProt C nucleus
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0019899 IPI:UniProtKB F enzyme binding
GO:0008429 TAS:ProtInc F phosphatidylethanolamine binding
GO:0044822 IDA:UniProtKB F poly(A) RNA binding
GO:0019901 IPI:UniProtKB F protein kinase binding
GO:0004867 IEA:UniProtKB-KW F serine-type endopeptidase inhibitor activity

Domain Information

InterPro Annotations

Accession Description
IPR008914 Phosphatidylethanolamine-binding protein PEBP
IPR001858 Phosphatidylethanolamine-binding, conserved site

UniProt Annotations

Entry Information

Gene Name
phosphatidylethanolamine binding protein 1
Protein Entry
PEBP1_HUMAN
UniProt ID
P30086
Species
Human

Comments

Comment Type Description
Function Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. {ECO:0000250, ECO:0000269|PubMed:18294816}.
Function HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity). {ECO:0000250}.
Interaction P04049:RAF1; NbExp=7; IntAct=EBI-716384, EBI-365996;
Similarity Belongs to the phosphatidylethanolamine-binding protein family. {ECO:0000305}.
Subcellular Location Cytoplasm {ECO:0000250}.
Subunit Has a tendency to form dimers by disulfide cross-linking (By similarity). Interacts with RAF1 and this interaction is enhanced if RAF1 is phosphorylated on residues 'Ser-338', 'Ser- 339', 'Tyr-340' and 'Tyr-341'. Interacts with ALOX15; in response to IL13/interleukin-13, prevents the interaction of PEBP1 with RAF1 to activate the ERK signaling cascade. {ECO:0000250, ECO:0000269|PubMed:10490027, ECO:0000269|PubMed:18294816, ECO:0000269|PubMed:21831839}.
Web Resource Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/PEBP1ID44021ch12q24.html";

Identical and Related Proteins

Unique RefSeq proteins for LMP001830 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
4505621 RefSeq NP_002558 187 phosphatidylethanolamine-binding protein 1 preproprotein

Identical Sequences to LMP001830 proteins

Reference Database Accession Length Protein Name
GI:4505621 GenBank JAA17529.1 187 phosphatidylethanolamine binding protein 1 [Pan troglodytes]
GI:4505621 GenBank JAA17530.1 187 phosphatidylethanolamine binding protein 1 [Pan troglodytes]
GI:4505621 GenBank JAA28392.1 187 phosphatidylethanolamine binding protein 1 [Pan troglodytes]
GI:4505621 GenBank JAA40382.1 187 phosphatidylethanolamine binding protein 1 [Pan troglodytes]
GI:4505621 GenBank JAA40383.1 187 phosphatidylethanolamine binding protein 1 [Pan troglodytes]
GI:4505621 GenBank AGA52055.1 187 Sequence 42 from patent US 8329399

Related Sequences to LMP001830 proteins

Reference Database Accession Length Protein Name
GI:4505621 EMBL CAD33310.1 233 unnamed protein product [Homo sapiens]
GI:4505621 GenBank AAB32876.1 186 neuropolypeptide h3 [Homo sapiens]
GI:4505621 GenBank ACK24436.1 223 Sequence 12 from patent US 7452678
GI:4505621 GenBank JAB39754.1 187 phosphatidylethanolamine-binding protein 1 preproprotein [Callithrix jacchus]
GI:4505621 RefSeq XP_004054017.1 187 PREDICTED: phosphatidylethanolamine-binding protein 1 [Gorilla gorilla gorilla]
GI:4505621 RefSeq XP_509413.3 266 PREDICTED: phosphatidylethanolamine-binding protein 1 [Pan troglodytes]