Gene/Proteome Database (LMPD)

LMPD ID
LMP001831
Gene ID
51302
Species
Homo sapiens (Human)
Gene Name
cytochrome P450, family 39, subfamily A, polypeptide 1
Gene Symbol
CYP39A1
Synonyms
-
Chromosome
6
Map Location
6p21.1-p11.2
EC Number
1.14.13.99
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is involved in the conversion of cholesterol to bile acids. Its substrates include the oxysterols 25-hydroxycholesterol, 27-hydroxycholesterol and 24-hydroxycholesterol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Orthologs
View orthologs and multiple alignments for CYP39A1

Proteins

24-hydroxycholesterol 7-alpha-hydroxylase isoform 1
Refseq ID NP_057677
Protein GI 32313587
UniProt ID Q9NYL5
mRNA ID NM_016593
Length 469
RefSeq Status REVIEWED
MELISPTVIIILGCLALFLLLQRKNLRRPPCIKGWIPWIGVGFEFGKAPLEFIEKARIKYGPIFTVFAMGNRMTFVTEEEGINVFLKSKKVDFELAVQNIVYRTASIPKNVFLALHEKLYIMLKGKMGTVNLHQFTGQLTEELHEQLENLGTHGTMDLNNLVRHLLYPVTVNMLFNKSLFSTNKKKIKEFHQYFQVYDEDFEYGSQLPECLLRNWSKSKKWFLELFEKNIPDIKACKSAKDNSMTLLQATLDIVETETSKENSPNYGLLLLWASLSNAVPVAFWTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDLENLLLIKWCVLETIRLKAPGVITRKVVKPVEILNYIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEKHSFLDCFMAFGSGKFQCPARWFALLEVQMCIILILYKYDCSLLDPLPKQSYLHLVGVPQPEGQCRIEYKQRI
24-hydroxycholesterol 7-alpha-hydroxylase isoform 2
Refseq ID NP_001265667
Protein GI 525313655
UniProt ID Q9NYL5
mRNA ID NM_001278738
Length 449
RefSeq Status REVIEWED
MELISPTVIIILGCLALFLLLQRKNLRRPPCIKGWIPWIGVGFEFGKAPLEFIEKARIKYGPIFTVFAMGNRMTFVTEEEGINVFLKSKKVDFELAVQNIVYRTGKMGTVNLHQFTGQLTEELHEQLENLGTHGTMDLNNLVRHLLYPVTVNMLFNKSLFSTNKKKIKEFHQYFQVYDEDFEYGSQLPECLLRNWSKSKKWFLELFEKNIPDIKACKSAKDNSMTLLQATLDIVETETSKENSPNYGLLLLWASLSNAVPVAFWTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDLENLLLIKWCVLETIRLKAPGVITRKVVKPVEILNYIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEKHSFLDCFMAFGSGKFQCPARWFALLEVQMCIILILYKYDCSLLDPLPKQSYLHLVGVPQPEGQCRIEYKQRI
24-hydroxycholesterol 7-alpha-hydroxylase isoform 3
Refseq ID NP_001265668
Protein GI 525313660
UniProt ID Q9NYL5
mRNA ID NM_001278739
Length 297
RefSeq Status REVIEWED
MLFNKSLFSTNKKKIKEFHQYFQVYDEDFEYGSQLPECLLRNWSKSKKWFLELFEKNIPDIKACKSAKDNSMTLLQATLDIVETETSKENSPNYGLLLLWASLSNAVPVAFWTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDLENLLLIKWCVLETIRLKAPGVITRKVVKPVEILNYIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEKHSFLDCFMAFGSGKFQCPARWFALLEVQMCIILILYKYDCSLLDPLPKQSYLHLVGVPQPEGQCRIEYKQRI

Gene Information

Entrez Gene ID
51302
Gene Name
cytochrome P450, family 39, subfamily A, polypeptide 1
Gene Symbol
CYP39A1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0043231 TAS:UniProtKB C intracellular membrane-bounded organelle
GO:0033782 IEA:UniProtKB-EC F 24-hydroxycholesterol 7alpha-hydroxylase activity
GO:0020037 IEA:InterPro F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0008396 IDA:UniProtKB F oxysterol 7-alpha-hydroxylase activity
GO:0008387 IEA:Ensembl F steroid 7-alpha-hydroxylase activity
GO:0006699 IDA:UniProtKB P bile acid biosynthetic process
GO:0030573 IEA:UniProtKB-KW P bile acid catabolic process
GO:0008206 TAS:Reactome P bile acid metabolic process
GO:0006707 IEA:Ensembl P cholesterol catabolic process
GO:0007586 TAS:UniProtKB P digestion
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0016125 TAS:Reactome P sterol metabolic process
GO:0006805 TAS:Reactome P xenobiotic metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00120 Primary bile acid biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_11053 Synthesis of bile acids and bile salts via 24-hydroxycholesterol

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR024204 Cytochrome P450, cholesterol 7-alpha-monooxygenase-type
IPR002403 Cytochrome P450, E-class, group IV

UniProt Annotations

Entry Information

Gene Name
cytochrome P450, family 39, subfamily A, polypeptide 1
Protein Entry
CP39A_HUMAN
UniProt ID
Q9NYL5
Species
Human

Comments

Comment Type Description
Catalytic Activity (24R)-cholest-5-ene-3-beta,24-diol + NADPH + O(2) = (24R)-cholest-5-ene-3-beta,7-alpha,24-triol + NADP(+) + H(2)O.
Cofactor Name=heme; Xref=ChEBI
Function Involved in the bile acid metabolism. Has a preference for 24-hydroxycholesterol, and converts it into a 7-alpha- hydroxylated product.
Similarity Belongs to the cytochrome P450 family.
Subcellular Location Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue Specificity Liver specific.

Identical and Related Proteins

Unique RefSeq proteins for LMP001831 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
32313587 RefSeq NP_057677 469 24-hydroxycholesterol 7-alpha-hydroxylase isoform 1
525313655 RefSeq NP_001265667 449 24-hydroxycholesterol 7-alpha-hydroxylase isoform 2
525313660 RefSeq NP_001265668 297 24-hydroxycholesterol 7-alpha-hydroxylase isoform 3

Identical Sequences to LMP001831 proteins

Reference Database Accession Length Protein Name
GI:32313587 DBBJ BAF84952.1 469 unnamed protein product [Homo sapiens]
GI:32313587 SwissProt Q9NYL5.2 469 RecName: Full=24-hydroxycholesterol 7-alpha-hydroxylase; AltName: Full=Cytochrome P450 39A1; Short=hCYP39A1; AltName: Full=Oxysterol 7-alpha-hydroxylase [Homo sapiens]

Related Sequences to LMP001831 proteins

Reference Database Accession Length Protein Name
GI:525313655 DBBJ BAF84952.1 469 unnamed protein product [Homo sapiens]
GI:525313660 DBBJ BAF84952.1 469 unnamed protein product [Homo sapiens]
GI:525313660 DBBJ BAH13522.1 449 unnamed protein product [Homo sapiens]
GI:525313655 DBBJ BAH13522.1 449 unnamed protein product [Homo sapiens]
GI:32313587 GenBank AAF63329.1 469 oxysterol 7alpha-hydroxylase [Homo sapiens]
GI:32313587 GenBank AAH10358.1 469 Cytochrome P450, family 39, subfamily A, polypeptide 1 [Homo sapiens]
GI:32313587 GenBank EAX04297.1 469 cytochrome P450, family 39, subfamily A, polypeptide 1 [Homo sapiens]
GI:525313655 GenBank EAX04297.1 469 cytochrome P450, family 39, subfamily A, polypeptide 1 [Homo sapiens]
GI:32313587 GenBank ABM83815.1 469 cytochrome P450, family 39, subfamily A, polypeptide 1 [synthetic construct]
GI:525313660 GenBank ABM83815.1 469 cytochrome P450, family 39, subfamily A, polypeptide 1 [synthetic construct]
GI:32313587 GenBank ABW03520.1 469 cytochrome P450, family 39, subfamily A, polypeptide 1, partial [synthetic construct]
GI:32313587 GenBank AIC56434.1 469 CYP39A1, partial [synthetic construct]
GI:525313655 RefSeq NP_057677.2 469 24-hydroxycholesterol 7-alpha-hydroxylase isoform 1 [Homo sapiens]
GI:525313660 RefSeq NP_057677.2 469 24-hydroxycholesterol 7-alpha-hydroxylase isoform 1 [Homo sapiens]
GI:525313655 RefSeq XP_003311399.1 449 PREDICTED: 24-hydroxycholesterol 7-alpha-hydroxylase isoform X4 [Pan troglodytes]
GI:525313660 RefSeq NP_001265667.1 449 24-hydroxycholesterol 7-alpha-hydroxylase isoform 2 [Homo sapiens]
GI:525313660 SwissProt Q9NYL5.2 469 RecName: Full=24-hydroxycholesterol 7-alpha-hydroxylase; AltName: Full=Cytochrome P450 39A1; Short=hCYP39A1; AltName: Full=Oxysterol 7-alpha-hydroxylase [Homo sapiens]
GI:525313655 SwissProt Q9NYL5.2 469 RecName: Full=24-hydroxycholesterol 7-alpha-hydroxylase; AltName: Full=Cytochrome P450 39A1; Short=hCYP39A1; AltName: Full=Oxysterol 7-alpha-hydroxylase [Homo sapiens]