Gene/Proteome Database (LMPD)
LMPD ID
LMP001838
Gene ID
Species
Homo sapiens (Human)
Gene Name
lipase, member H
Gene Symbol
Synonyms
AH; ARWH2; HYPT7; LAH2; LPDLR; PLA1B; mPA-PLA1
Alternate Names
lipase member H; lipase H; mPA-PLA1 alpha; phospholipase A1 member B; LPD lipase-related protein; membrane-bound phosphatidic acid-selective phospholipase A1; membrane-associated phosphatidic acid-selective phospholipase A1-alpha
Chromosome
3
Map Location
3q27
EC Number
3.1.1.-
Summary
This gene encodes a membrane-bound member of the mammalian triglyceride lipase family. It catalyzes the production of 2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| lipase member H precursor | |
|---|---|
| Refseq ID | NP_640341 |
| Protein GI | 21245106 |
| UniProt ID | Q8WWY8 |
| mRNA ID | NM_139248 |
| Length | 451 |
| RefSeq Status | REVIEWED |
| MLRFYLFISLLCLSRSDAEETCPSFTRLSFHSAVVGTGLNVRLMLYTRKNLTCAQTINSSAFGNLNVTKKTTFIVHGFRPTGSPPVWMDDLVKGLLSVEDMNVVVVDWNRGATTLIYTHASSKTRKVAMVLKEFIDQMLAEGASLDDIYMIGVSLGAHISGFVGEMYDGWLGRITGLDPAGPLFNGKPHQDRLDPSDAQFVDVIHSDTDALGYKEPLGNIDFYPNGGLDQPGCPKTILGGFQYFKCDHQRSVYLYLSSLRESCTITAYPCDSYQDYRNGKCVSCGTSQKESCPLLGYYADNWKDHLRGKDPPMTKAFFDTAEESPFCMYHYFVDIITWNKNVRRGDITIKLRDKAGNTTESKINHEPTTFQKYHQVSLLARFNQDLDKVAAISLMFSTGSLIGPRYKLRILRMKLRSLAHPERPQLCRYDLVLMENVETVFQPILCPELQL | |
| sig_peptide: 1..18 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2149 peptide sequence: MLRFYLFISLLCLSRSDA mat_peptide: 19..451 product: lipase member H calculated_mol_wt: 48729 peptide sequence: EETCPSFTRLSFHSAVVGTGLNVRLMLYTRKNLTCAQTINSSAFGNLNVTKKTTFIVHGFRPTGSPPVWMDDLVKGLLSVEDMNVVVVDWNRGATTLIYTHASSKTRKVAMVLKEFIDQMLAEGASLDDIYMIGVSLGAHISGFVGEMYDGWLGRITGLDPAGPLFNGKPHQDRLDPSDAQFVDVIHSDTDALGYKEPLGNIDFYPNGGLDQPGCPKTILGGFQYFKCDHQRSVYLYLSSLRESCTITAYPCDSYQDYRNGKCVSCGTSQKESCPLLGYYADNWKDHLRGKDPPMTKAFFDTAEESPFCMYHYFVDIITWNKNVRRGDITIKLRDKAGNTTESKINHEPTTFQKYHQVSLLARFNQDLDKVAAISLMFSTGSLIGPRYKLRILRMKLRSLAHPERPQLCRYDLVLMENVETVFQPILCPELQL | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005615 | IDA:UniProtKB | C | extracellular space |
| GO:0005886 | IDA:UniProtKB | C | plasma membrane |
| GO:0008201 | IDA:UniProtKB | F | heparin binding |
| GO:0004620 | IDA:UniProtKB | F | phospholipase activity |
| GO:0016042 | IDA:UniProtKB | P | lipid catabolic process |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Disease | Hypotrichosis 7 (HYPT7) [MIM |
| Disease | Woolly hair autosomal recessive 2 (ARWH2) [MIM |
| Enzyme Regulation | Inhibited by sodium vanadate. |
| Function | Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG). |
| Sequence Caution | Sequence=BAB85023.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; |
| Similarity | Belongs to the AB hydrolase superfamily. Lipase family. |
| Subcellular Location | Secreted. Membrane; Peripheral membrane protein. |
| Tissue Specificity | Present in intestine (at protein level). Expressed in colon, prostate, kidney, pancreas, ovary, testis, intestine, lung and pancreas. Expressed at lower level in brain, spleen and heart. In hair, it is prominently expressed in hair follicles, including the stem cell-rich bulge region. {ECO |
Identical and Related Proteins
Unique RefSeq proteins for LMP001838 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 21245106 | RefSeq | NP_640341 | 451 | lipase member H precursor |
Identical Sequences to LMP001838 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:21245106 | DBBJ | BAG53642.1 | 451 | unnamed protein product [Homo sapiens] |
| GI:21245106 | GenBank | EAW78218.1 | 451 | lipase, member H [Homo sapiens] |
| GI:21245106 | GenBank | ABM67095.1 | 451 | lipase H [Homo sapiens] |
| GI:21245106 | GenBank | ACE17021.1 | 451 | Sequence 5 from patent US 7368270 |
| GI:21245106 | GenBank | ADQ32559.1 | 451 | lipase, member H, partial [synthetic construct] |
| GI:21245106 | GenBank | AIC53380.1 | 451 | LIPH, partial [synthetic construct] |
Related Sequences to LMP001838 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:21245106 | GenBank | AFI36466.1 | 451 | lipase member H precursor [Macaca mulatta] |
| GI:21245106 | GenBank | AFJ70790.1 | 451 | lipase member H precursor [Macaca mulatta] |
| GI:21245106 | RefSeq | XP_003256633.1 | 451 | PREDICTED: lipase member H isoform 1 [Nomascus leucogenys] |
| GI:21245106 | RefSeq | XP_516924.3 | 451 | PREDICTED: lipase member H isoform X1 [Pan troglodytes] |
| GI:21245106 | RefSeq | XP_003806656.1 | 451 | PREDICTED: lipase member H isoform X1 [Pan paniscus] |
| GI:21245106 | RefSeq | XP_010374896.1 | 451 | PREDICTED: lipase member H [Rhinopithecus roxellana] |