Gene/Proteome Database (LMPD)

LMPD ID
LMP001845
Gene ID
4836
Species
Homo sapiens (Human)
Gene Name
N-myristoyltransferase 1
Gene Symbol
NMT1
Synonyms
NMT
Alternate Names
glycylpeptide N-tetradecanoyltransferase 1; NMT 1; long form, NMT-L; alternative, short form NMT-S; type I N-myristoyltransferase; peptide N-myristoyltransferase 1; myristoyl-CoA:protein N-myristoyltransferase 1
Chromosome
17
Map Location
17q21.31
EC Number
2.3.1.97
Summary
Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311) (Duronio et al., 1992 [PubMed 1570339]).[supplied by OMIM, Nov 2008]
Orthologs
View orthologs and multiple alignments for NMT1

Proteins

glycylpeptide N-tetradecanoyltransferase 1
Refseq ID NP_066565
Protein GI 10835073
UniProt ID P30419
mRNA ID NM_021079
Length 496
RefSeq Status PROVISIONAL
MADESETAVKPPAPPLPQMMEGNGNGHEHCSDCENEEDNSYNRGGLSPANDTGAKKKKKKQKKKKEKGSETDSAQDQPVKMNSLPAERIQEIQKAIELFSVGQGPAKTMEEASKRSYQFWDTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQGFTWDALDLGDRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEKKMVEINFLCVHKKLRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRSLNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMETKDIPVVHQLLTRYLKQFHLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNHPTHKSLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWKCPSMGAEKVGLVLQ

Gene Information

Entrez Gene ID
4836
Gene Name
N-myristoyltransferase 1
Gene Symbol
NMT1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0015629 IDA:HPA C actin cytoskeleton
GO:0030054 IDA:HPA C cell junction
GO:0005737 IDA:HPA C cytoplasm
GO:0005829 TAS:Reactome C cytosol
GO:0005886 IDA:HPA C plasma membrane
GO:0003824 TAS:ProtInc F catalytic activity
GO:0004379 IEA:UniProtKB-EC F glycylpeptide N-tetradecanoyltransferase activity
GO:0006499 IEA:Ensembl P N-terminal protein myristoylation
GO:0006915 TAS:Reactome P apoptotic process
GO:0001701 IEA:Ensembl P in utero embryonic development
GO:0097193 TAS:Reactome P intrinsic apoptotic signaling pathway
GO:0007603 TAS:Reactome P phototransduction, visible light
GO:1900740 TAS:Reactome P positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0009249 TAS:ProtInc P protein lipoylation
GO:0022400 TAS:Reactome P regulation of rhodopsin mediated signaling pathway
GO:0016056 TAS:Reactome P rhodopsin mediated signaling pathway
GO:0016032 TAS:Reactome P viral process

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_701 Activation, myristolyation of BID and translocation to mitochondria
REACT_163919 Inactivation, recovery and regulation of the phototransduction cascade
REACT_163722 The phototransduction cascade
REACT_160125 Visual phototransduction

Domain Information

InterPro Annotations

Accession Description
IPR016181 Acyl-CoA N-acyltransferase
IPR000903 Myristoyl-CoA:protein N-myristoyltransferase
IPR022677 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal
IPR022676 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal
IPR022678 Myristoyl-CoA:protein N-myristoyltransferase, conserved site

UniProt Annotations

Entry Information

Gene Name
N-myristoyltransferase 1
Protein Entry
NMT1_HUMAN
UniProt ID
P30419
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=P30419-1; Sequence=Displayed; Name=Short; IsoId=P30419-2; Sequence=VSP_003570;
Catalytic Activity Tetradecanoyl-CoA + glycylpeptide = CoA + N- tetradecanoylglycylpeptide.
Function Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.
Sequence Caution Sequence=AAC09294.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the NMT family.
Subcellular Location Cytoplasm.
Tissue Specificity Heart, gut, kidney, liver and placenta.
Web Resource Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/NMT1ID43604ch17q21.html";

Identical and Related Proteins

Unique RefSeq proteins for LMP001845 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
10835073 RefSeq NP_066565 496 glycylpeptide N-tetradecanoyltransferase 1

Identical Sequences to LMP001845 proteins

Reference Database Accession Length Protein Name
GI:10835073 DBBJ BAI45680.1 496 N-myristoyltransferase 1, partial [synthetic construct]
GI:10835073 GenBank JAA07986.1 496 N-myristoyltransferase 1 [Pan troglodytes]
GI:10835073 GenBank JAA11963.1 496 N-myristoyltransferase 1 [Pan troglodytes]
GI:10835073 GenBank JAA40215.1 496 N-myristoyltransferase 1 [Pan troglodytes]
GI:10835073 GenBank AHD69576.1 496 Sequence 590 from patent US 8586006
GI:10835073 GenBank AIC49295.1 496 NMT1, partial [synthetic construct]

Related Sequences to LMP001845 proteins

Reference Database Accession Length Protein Name
GI:10835073 PDB 1RXT 496 Chain A, Crystal Structure Of Human Myristoyl-Coa:protein N- Myristoyltransferase.
GI:10835073 PDB 1RXT 496 Chain B, Crystal Structure Of Human Myristoyl-Coa:protein N- Myristoyltransferase.
GI:10835073 PDB 1RXT 496 Chain C, Crystal Structure Of Human Myristoyl-Coa:protein N- Myristoyltransferase.
GI:10835073 PDB 1RXT 496 Chain D, Crystal Structure Of Human Myristoyl-Coa:protein N- Myristoyltransferase.
GI:10835073 RefSeq XP_005257479.1 521 PREDICTED: glycylpeptide N-tetradecanoyltransferase 1 isoform X2 [Homo sapiens]
GI:10835073 RefSeq XP_003806571.2 521 PREDICTED: glycylpeptide N-tetradecanoyltransferase 1 [Pan paniscus]