Gene/Proteome Database (LMPD)

LMPD ID
LMP001852
Gene ID
6720
Species
Homo sapiens (Human)
Gene Name
sterol regulatory element binding transcription factor 1
Gene Symbol
SREBF1
Synonyms
SREBP-1c; SREBP1; bHLHd1
Alternate Names
sterol regulatory element-binding protein 1; SREBP-1; class D basic helix-loop-helix protein 1
Chromosome
17
Map Location
17p11.2
Summary
This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for SREBF1

Proteins

sterol regulatory element-binding protein 1 isoform a
Refseq ID NP_001005291
Protein GI 52630419
UniProt ID P36956
mRNA ID NM_001005291
Length 1177
RefSeq Status REVIEWED
MDEPPFSEAALEQALGEPCDLDAALLTDIEGEVGAGRGRANGLDAPRAGADRGAMDCTFEDMLQLINNQDSDFPGLFDPPYAGSGAGGTDPASPDTSSPGSLSPPPATLSSSLEAFLSGPQAAPSPLSPPQPAPTPLKMYPSMPAFSPGPGIKEESVPLSILQTPTPQPLPGALLPQSFPAPAPPQFSSTPVLGYPSPPGGFSTGSPPGNTQQPLPGLPLASPPGVPPVSLHTQVQSVVPQQLLTVTAAPTAAPVTTTVTSQIQQVPVLLQPHFIKADSLLLTAMKTDGATVKAAGLSPLVSGTTVQTGPLPTLVSGGTILATVPLVVDAEKLPINRLAAGSKAPASAQSRGEKRTAHNAIEKRYRSSINDKIIELKDLVVGTEAKLNKSAVLRKAIDYIRFLQHSNQKLKQENLSLRTAVHKSKSLKDLVSACGSGGNTDVLMEGVKTEVEDTLTPPPSDAGSPFQSSPLSLGSRGSGSGGSGSDSEPDSPVFEDSKAKPEQRPSLHSRGMLDRSRLALCTLVFLCLSCNPLASLLGARGLPSPSDTTSVYHSPGRNVLGTESRDGPGWAQWLLPPVVWLLNGLLVLVSLVLLFVYGEPVTRPHSGPAVYFWRHRKQADLDLARGDFAQAAQQLWLALRALGRPLPTSHLDLACSLLWNLIRHLLQRLWVGRWLAGRAGGLQQDCALRVDASASARDAALVYHKLHQLHTMGKHTGGHLTATNLALSALNLAECAGDAVSVATLAEIYVAAALRVKTSLPRALHFLTRFFLSSARQACLAQSGSVPPAMQWLCHPVGHRFFVDGDWSVLSTPWESLYSLAGNPVDPLAQVTQLFREHLLERALNCVTQPNPSPGSADGDKEFSDALGYLQLLNSCSDAAGAPAYSFSISSSMATTTGVDPVAKWWASLTAVVIHWLRRDEEAAERLCPLVEHLPRVLQESERPLPRAALHSFKAARALLGCAKAESGPASLTICEKASGYLQDSLATTPASSSIDKAVQLFLCDLLLVVRTSLWRQQQPPAPAPAAQGTSSRPQASALELRGFQRDLSSLRRLAQSFRPAMRRVFLHEATARLMAGASPTRTHQLLDRSLRRRAGPGGKGGAVAELEPRPTRREHAEALLLASCYLPPGFLSAPGQRVGMLAEAARTLEKLGDRRLLHDCQQMLMRLGGGTTVTSS
sterol regulatory element-binding protein 1 isoform b
Refseq ID NP_004167
Protein GI 22547195
UniProt ID P36956
mRNA ID NM_004176
Length 1147
RefSeq Status REVIEWED
MDEPPFSEAALEQALGEPCDLDAALLTDIEDMLQLINNQDSDFPGLFDPPYAGSGAGGTDPASPDTSSPGSLSPPPATLSSSLEAFLSGPQAAPSPLSPPQPAPTPLKMYPSMPAFSPGPGIKEESVPLSILQTPTPQPLPGALLPQSFPAPAPPQFSSTPVLGYPSPPGGFSTGSPPGNTQQPLPGLPLASPPGVPPVSLHTQVQSVVPQQLLTVTAAPTAAPVTTTVTSQIQQVPVLLQPHFIKADSLLLTAMKTDGATVKAAGLSPLVSGTTVQTGPLPTLVSGGTILATVPLVVDAEKLPINRLAAGSKAPASAQSRGEKRTAHNAIEKRYRSSINDKIIELKDLVVGTEAKLNKSAVLRKAIDYIRFLQHSNQKLKQENLSLRTAVHKSKSLKDLVSACGSGGNTDVLMEGVKTEVEDTLTPPPSDAGSPFQSSPLSLGSRGSGSGGSGSDSEPDSPVFEDSKAKPEQRPSLHSRGMLDRSRLALCTLVFLCLSCNPLASLLGARGLPSPSDTTSVYHSPGRNVLGTESRDGPGWAQWLLPPVVWLLNGLLVLVSLVLLFVYGEPVTRPHSGPAVYFWRHRKQADLDLARGDFAQAAQQLWLALRALGRPLPTSHLDLACSLLWNLIRHLLQRLWVGRWLAGRAGGLQQDCALRVDASASARDAALVYHKLHQLHTMGKHTGGHLTATNLALSALNLAECAGDAVSVATLAEIYVAAALRVKTSLPRALHFLTRFFLSSARQACLAQSGSVPPAMQWLCHPVGHRFFVDGDWSVLSTPWESLYSLAGNPVDPLAQVTQLFREHLLERALNCVTQPNPSPGSADGDKEFSDALGYLQLLNSCSDAAGAPAYSFSISSSMATTTGVDPVAKWWASLTAVVIHWLRRDEEAAERLCPLVEHLPRVLQESERPLPRAALHSFKAARALLGCAKAESGPASLTICEKASGYLQDSLATTPASSSIDKAVQLFLCDLLLVVRTSLWRQQQPPAPAPAAQGTSSRPQASALELRGFQRDLSSLRRLAQSFRPAMRRVFLHEATARLMAGASPTRTHQLLDRSLRRRAGPGGKGGAVAELEPRPTRREHAEALLLASCYLPPGFLSAPGQRVGMLAEAARTLEKLGDRRLLHDCQQMLMRLGGGTTVTSS

Gene Information

Entrez Gene ID
6720
Gene Name
sterol regulatory element binding transcription factor 1
Gene Symbol
SREBF1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0000139 TAS:Reactome C Golgi membrane
GO:0005737 ISS:UniProtKB C cytoplasm
GO:0031410 IEA:UniProtKB-KW C cytoplasmic vesicle
GO:0005829 TAS:Reactome C cytosol
GO:0005783 IDA:UniProtKB C endoplasmic reticulum
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005635 TAS:ProtInc C nuclear envelope
GO:0005654 TAS:Reactome C nucleoplasm
GO:0005634 IDA:BHF-UCL C nucleus
GO:0043234 IEA:Ensembl C protein complex
GO:0003677 ISS:UniProtKB F DNA binding
GO:0003682 IEA:Ensembl F chromatin binding
GO:0043565 IEA:Ensembl F sequence-specific DNA binding
GO:0003700 IDA:HGNC F sequence-specific DNA binding transcription factor activity
GO:0032810 IDA:HGNC F sterol response element binding
GO:0007568 IEA:Ensembl P aging
GO:0044255 TAS:Reactome P cellular lipid metabolic process
GO:0071398 IEA:Ensembl P cellular response to fatty acid
GO:0009267 ISS:HGNC P cellular response to starvation
GO:0008203 IEA:UniProtKB-KW P cholesterol metabolic process
GO:0007623 IEA:Ensembl P circadian rhythm
GO:0008286 IEA:Ensembl P insulin receptor signaling pathway
GO:0008610 ISS:UniProtKB P lipid biosynthetic process
GO:0006629 TAS:ProtInc P lipid metabolic process
GO:0030324 IEA:Ensembl P lung development
GO:0046676 IEA:Ensembl P negative regulation of insulin secretion
GO:0000122 IEA:Ensembl P negative regulation of transcription from RNA polymerase II promoter
GO:0045542 IEA:Ensembl P positive regulation of cholesterol biosynthetic process
GO:0031065 IEA:Ensembl P positive regulation of histone deacetylation
GO:0045944 IDA:UniProtKB P positive regulation of transcription from RNA polymerase II promoter
GO:0010867 ISS:UniProtKB P positive regulation of triglyceride biosynthetic process
GO:0019217 IEA:Ensembl P regulation of fatty acid metabolic process
GO:0003062 IEA:Ensembl P regulation of heart rate by chemical signal
GO:0006357 TAS:ProtInc P regulation of transcription from RNA polymerase II promoter
GO:0051591 IEA:Ensembl P response to cAMP
GO:0042493 IEA:Ensembl P response to drug
GO:0032094 IEA:Ensembl P response to food
GO:0033762 IEA:Ensembl P response to glucagon
GO:0009749 IEA:Ensembl P response to glucose
GO:0032570 IEA:Ensembl P response to progesterone
GO:0032526 IEA:Ensembl P response to retinoic acid
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0006351 IEA:UniProtKB-KW P transcription, DNA-templated

KEGG Pathway Links

KEGG Pathway ID Description
hsa04152 AMPK signaling pathway
hsa04932 Non-alcoholic fatty liver disease (NAFLD)

Domain Information

InterPro Annotations

Accession Description
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain

UniProt Annotations

Entry Information

Gene Name
sterol regulatory element binding transcription factor 1
Protein Entry
SRBP1_HUMAN
UniProt ID
P36956
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=6; Comment=Additional isoforms seem to exist.; Name=SREBP-1A; IsoId=P36956-1; Sequence=Displayed; Name=SREBP-1B; IsoId=P36956-2; Sequence=VSP_002150; Name=SREBP-1C; IsoId=P36956-3; Sequence=VSP_002149, VSP_002150; Note=Predominantly expressed in liver and adipose tissues.; Name=4; IsoId=P36956-4; Sequence=VSP_030859; Note=No experimental confirmation available.; Name=SREBP-1aDelta; IsoId=P36956-5; Sequence=VSP_047598, VSP_047599; Note=The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters.; Name=SREBP-1cDelta; IsoId=P36956-6; Sequence=VSP_002149, VSP_047598, VSP_047599; Note=The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters.;
Function Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').
Interaction P45481:Crebbp (xeno); NbExp=2; IntAct=EBI-948328, EBI-296306; Q96RN5:MED15; NbExp=6; IntAct=EBI-948328, EBI-394506; Q96EB6:SIRT1; NbExp=2; IntAct=EBI-948338, EBI-1802965;
Ptm At low cholesterol the SCAP/SREBP complex is recruited into COPII vesicles for export from the ER. In the Golgi complex SREBPs are cleaved sequentially by site-1 and site-2 protease. The first cleavage by site-1 protease occurs within the luminal loop, the second cleavage by site-2 protease occurs within the first transmembrane domain and releases the transcription factor from the Golgi membrane. Apoptosis triggers cleavage by the cysteine proteases caspase-3 and caspase-7.
Ptm Phosphorylated by AMPK, leading to suppress protein processing and nuclear translocation, and repress target gene expression. Phosphorylation at Ser-402 by SIK1 represses activity possibly by inhibiting DNA-binding (By similarity).
Sequence Caution Sequence=AAB28522.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=BAD92846.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence= ;
Similarity Belongs to the SREBP family.
Similarity Contains 1 bHLH (basic helix-loop-helix) domain.
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols.
Subcellular Location Isoform SREBP-1aDelta: Nucleus {ECO
Subcellular Location Isoform SREBP-1cDelta: Nucleus {ECO
Subcellular Location Processed sterol regulatory element-binding protein 1: Nucleus.
Subunit Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA.
Tissue Specificity Expressed in a wide variety of tissues, most abundant in liver and adrenal gland. In fetal tissues lung and liver shows highest expression. Isoform SREBP-1C predominates in liver, adrenal gland and ovary, whereas isoform SREBP-1A predominates in hepatoma cell lines. Isoform SREBP-1A and isoform SREBP-1C are found in kidney, brain, white fat, and muscle.
Web Resource Name=Wikipedia; Note=Sterol regulatory element- binding protein entry; URL="http://en.wikipedia.org/wiki/Sterol_regulatory_element_binding_protein";

Identical and Related Proteins

Unique RefSeq proteins for LMP001852 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
52630419 RefSeq NP_001005291 1177 sterol regulatory element-binding protein 1 isoform a
22547195 RefSeq NP_004167 1147 sterol regulatory element-binding protein 1 isoform b

Identical Sequences to LMP001852 proteins

Reference Database Accession Length Protein Name
GI:22547195 GenBank AAH57388.1 1147 Sterol regulatory element binding transcription factor 1 [Homo sapiens]
GI:22547195 GenBank EAW55689.1 1147 sterol regulatory element binding transcription factor 1, isoform CRA_b [Homo sapiens]
GI:22547195 GenBank EAW55690.1 1147 sterol regulatory element binding transcription factor 1, isoform CRA_b [Homo sapiens]
GI:52630419 GenBank EAW55691.1 1177 sterol regulatory element binding transcription factor 1, isoform CRA_c [Homo sapiens]
GI:52630419 GenBank AGO77694.1 1177 Sequence 48 from patent US 8399210
GI:52630419 GenBank AHD73544.1 1177 Sequence 10612 from patent US 8586006
GI:22547195 GenBank AHD73545.1 1147 Sequence 10613 from patent US 8586006
GI:22547195 GenBank AIC55167.1 1147 SREBF1, partial [synthetic construct]
GI:22547195 SwissProt P36956.2 1147 RecName: Full=Sterol regulatory element-binding protein 1; Short=SREBP-1; AltName: Full=Class D basic helix-loop-helix protein 1; Short=bHLHd1; AltName: Full=Sterol regulatory element-binding transcription factor 1; Contains: RecName: Full=Processed sterol regulatory element-binding protein 1 [Homo sapiens]

Related Sequences to LMP001852 proteins

Reference Database Accession Length Protein Name
GI:22547195 GenBank AAC50051.2 1147 SREBP-1 [Homo sapiens]
GI:52630419 GenBank AAH63281.1 1177 Sterol regulatory element binding transcription factor 1 [Homo sapiens]
GI:52630419 GenBank EAW55690.1 1147 sterol regulatory element binding transcription factor 1, isoform CRA_b [Homo sapiens]
GI:22547195 GenBank ACM84347.1 1164 Sequence 9845 from patent US 6812339
GI:22547195 GenBank AFQ70482.1 1147 Sequence 24 from patent US 8227408
GI:22547195 GenBank JAA18845.1 1147 sterol regulatory element binding transcription factor 1 [Pan troglodytes]
GI:22547195 GenBank JAA26079.1 1147 sterol regulatory element binding transcription factor 1 [Pan troglodytes]
GI:52630419 RefSeq XP_004042224.1 1181 PREDICTED: sterol regulatory element-binding protein 1 [Gorilla gorilla gorilla]
GI:22547195 RefSeq XP_005256829.1 1145 PREDICTED: sterol regulatory element-binding protein 1 isoform X1 [Homo sapiens]
GI:52630419 RefSeq XP_005583090.1 1177 PREDICTED: sterol regulatory element-binding protein 1 isoform X1 [Macaca fascicularis]
GI:52630419 RefSeq XP_008008735.1 1296 PREDICTED: sterol regulatory element-binding protein 1 isoform X4 [Chlorocebus sabaeus]
GI:52630419 RefSeq XP_009188063.1 1177 PREDICTED: sterol regulatory element-binding protein 1 isoform X5 [Papio anubis]