Gene/Proteome Database (LMPD)

LMPD ID
LMP001861
Gene ID
78390
Species
Mus musculus (Mouse)
Gene Name
phospholipase A2, group IVD
Gene Symbol
Pla2g4d
Synonyms
2610311B01Rik; Pla2delta; cPLA2delta
Alternate Names
cytosolic phospholipase A2 delta; cPLA2-delta
Chromosome
2
Map Location
2 E5|2
EC Number
3.1.1.4

Proteins

cytosolic phospholipase A2 delta
Refseq ID NP_001019308
Protein GI 67906183
UniProt ID Q50L43
mRNA ID NM_001024137
Length 825
RefSeq Status PROVISIONAL
MWSGDRRVGMESLSPERLHGHPYQEEASVFCRLTVKILEARSLPRADLLSQADPYVTVQLPTASGMKFKTQTVTNSSHPVWNETFSFLIQSQVKNILELTIYDEDVITKDDICFKVSYDVSEILPGQLLQKTFSLNPQGPEELDVELLMERTWDPPENLITNNVLVARELSHLDVSLDRAGNTAMAAGQDKLELELMLKGSYEDTQTFFPDTAFTFSFHYMRGQDTELNGYLRGPRNSGWNSDTSVTPFNVPLMSLAAGKEMTIDIPAMKAPEGKLQLKTDCCPKELSVRLSYGLCPEEQAFLSRRKKVVAAALKQALQLDEDLNEDEVPVVGINAEGGGMRAMISLYGHLLALQKLGLLDCVTYFSGISGSTWTMAHLYRDPEWSQRDLEGPISHAREHVAKTLLKEFLPEHLASYRQTLKLREEQGYTVTVADLWGLVLESKLHGQVTDQKLSGQRAALERGQNPLPLYLSLNVKENHLETLHFKEWVEFSPYEVGFLKYGGFVPSELFGSEFFMGRLMKRLPESQICFLEGIWSNLFSVNLMDIWYDITYGKDSNNFPVDVRNSEKEFSGSAGTSSGVEAPWLESGTALAQALKGFLTGRPFHQRSANFLHGLQLHRDYCNQRHFSTWADCNLDDTPNQLTPQDPQLCLIDAGCFMNSSCPSLFRPGRQVDLIISFNYNQSLPFKGLQQSEKYSRARGLPFPRVEPSPEDHSQPQECYLFSDPTCPEAPVVLHFPLVNDSFRDHSAPGVRRSPDELKAGQVNLTGAASPYFMYNMTYKNEDFDRLLQLSDYNVQNNQGTILQALRTVLKRRASETRPLGVKT

Gene Information

Entrez Gene ID
78390
Gene Name
phospholipase A2, group IVD
Gene Symbol
Pla2g4d
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:MGI C cytoplasm
GO:0031410 IEA:UniProtKB-KW C cytoplasmic vesicle
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0004623 IDA:MGI F phospholipase A2 activity
GO:0009395 IEA:InterPro P phospholipid catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu04750 Inflammatory mediator regulation of TRP channels
mmu04921 Oxytocin signaling pathway
mmu04611 Platelet activation
mmu04014 Ras signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
IPR000008 C2 domain
IPR002642 Lysophospholipase, catalytic domain

UniProt Annotations

Entry Information

Gene Name
phospholipase A2, group IVD
Protein Entry
PA24D_MOUSE
UniProt ID
Q50L43
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Phosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate.
Domain The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity). {ECO:0000250}.
Enzyme Regulation Stimulated by cytosolic Ca(2+). {ECO:0000269|PubMed:15866882}.
Function Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Not arachidonic acid-specific but has linoleic acid-specific activity. May play a role in inflammation in psoriatic lesions. {ECO:0000269|PubMed:15866882}.
Similarity Contains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
Similarity Contains 1 PLA2c domain. {ECO:0000255|PROSITE- ProRule:PRU00555}.
Subcellular Location Cytoplasm, cytosol {ECO:0000269|PubMed:15866882}. Cytoplasmic vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Translocates to membrane vesicles in a calcium-dependent fashion. Translocates to perinuclear regions upon ionomycin stimulation.
Tissue Specificity Weakly or not expressed in most tissues. Detected in placenta of 17.5 dpc embryos. {ECO:0000269|PubMed:15866882}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001861 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
67906183 RefSeq NP_001019308 825 cytosolic phospholipase A2 delta

Identical Sequences to LMP001861 proteins

Reference Database Accession Length Protein Name
GI:67906183 DBBJ BAD98152.1 825 cytosolic phospholipase A2 delta [Mus musculus]
GI:67906183 SwissProt Q50L43.3 825 RecName: Full=Cytosolic phospholipase A2 delta; Short=cPLA2-delta; AltName: Full=Phospholipase A2 group IVD [Mus musculus]

Related Sequences to LMP001861 proteins

Reference Database Accession Length Protein Name
GI:67906183 DBBJ BAE39570.1 825 unnamed protein product [Mus musculus]
GI:67906183 DBBJ BAE26807.1 825 unnamed protein product [Mus musculus]
GI:67906183 GenBank AAI13161.1 825 Phospholipase A2, group IVD [Mus musculus]
GI:67906183 GenBank AAI13771.1 825 Phospholipase A2, group IVD [Mus musculus]
GI:67906183 GenBank AEU43287.1 825 Sequence 36 from patent US 8052970
GI:67906183 RefSeq XP_002726206.1 825 PREDICTED: cytosolic phospholipase A2 delta [Rattus norvegicus]