Gene/Proteome Database (LMPD)

LMPD ID
LMP001867
Gene ID
5915
Species
Homo sapiens (Human)
Gene Name
retinoic acid receptor, beta
Gene Symbol
RARB
Synonyms
HAP; MCOPS12; NR1B2; RRB2
Chromosome
3
Map Location
3p24.2
Summary
This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014]
Orthologs
View orthologs and multiple alignments for RARB

Proteins

retinoic acid receptor beta isoform 1
Refseq ID NP_000956
Protein GI 14916494
UniProt ID Q86UC5
mRNA ID NM_000965
Length 448
RefSeq Status REVIEWED
MFDCMDVLSVSPGQILDFYTASPSSCMLQEKALKACFSGLTQTEWQHRHTAQSIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHEPLTPSSSGNTAEHSPSISPSSVENSGVSQSPLVQ
retinoic acid receptor beta isoform 2
Refseq ID NP_001277146
Protein GI 590122018
UniProt ID Q5QHG3
mRNA ID NM_001290217
Length 336
RefSeq Status REVIEWED
MIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHEPLTPSSSGNTAEHSPSISPSSVENSGVSQSPLVQ
retinoic acid receptor beta isoform 2
Refseq ID NP_057236
Protein GI 7706625
UniProt ID Q5QHG3
mRNA ID NM_016152
Length 336
RefSeq Status REVIEWED
Protein sequence is identical to GI:590122018 (mRNA isoform)
retinoic acid receptor beta isoform 2
Refseq ID NP_001277205
Protein GI 590122040
UniProt ID Q86UC5
mRNA ID NM_001290276
Length 336
RefSeq Status REVIEWED
Protein sequence is identical to GI:590122018 (mRNA isoform)
retinoic acid receptor beta isoform 3
Refseq ID NP_001277145
Protein GI 590122016
UniProt ID P10826
mRNA ID NM_001290216
Length 455
RefSeq Status REVIEWED
MTTSGHACPVPAVNGHMTHYPATPYPLLFPPVIGGLSLPPLHGLHGHPPPSGCSTPSPATIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHEPLTPSSSGNTAEHSPSISPSSVENSGVSQSPLVQ
retinoic acid receptor beta isoform 4
Refseq ID NP_001277195
Protein GI 590122018
UniProt ID P10826
mRNA ID NM_001290266
Length 336
RefSeq Status REVIEWED
MIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHEPLTPSSSGNTAEHSPSISPSSVENSGVSQSPLVQ
retinoic acid receptor beta isoform 6
Refseq ID NP_001277229
Protein GI 590122040
UniProt ID Q3SB16
mRNA ID NM_001290300
Length 336
RefSeq Status REVIEWED
Protein sequence is identical to GI:590122018 (mRNA isoform)

Gene Information

Entrez Gene ID
5915
Gene Name
retinoic acid receptor, beta
Gene Symbol
RARB
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005654 TAS:Reactome C nucleoplasm
GO:0005634 IDA:UniProtKB C nucleus
GO:0003677 TAS:ProtInc F DNA binding
GO:0000977 IEA:Ensembl F RNA polymerase II regulatory region sequence-specific DNA binding
GO:0008144 IEA:Ensembl F drug binding
GO:0003708 TAS:ProtInc F retinoic acid receptor activity
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0048566 IMP:DFLAT P embryonic digestive tract development
GO:0048048 IEA:Ensembl P embryonic eye morphogenesis
GO:0035116 IEA:Ensembl P embryonic hindlimb morphogenesis
GO:0010467 TAS:Reactome P gene expression
GO:0002068 IEA:Ensembl P glandular epithelial cell development
GO:0003417 IEA:Ensembl P growth plate cartilage development
GO:0035264 IEA:Ensembl P multicellular organism growth
GO:0043066 IEA:Ensembl P negative regulation of apoptotic process
GO:0061037 IEA:Ensembl P negative regulation of cartilage development
GO:0008285 IEA:Ensembl P negative regulation of cell proliferation
GO:0032331 IEA:Ensembl P negative regulation of chondrocyte differentiation
GO:0000122 IEA:Ensembl P negative regulation of transcription from RNA polymerase II promoter
GO:0003148 IEA:Ensembl P outflow tract septum morphogenesis
GO:0043065 IEA:Ensembl P positive regulation of apoptotic process
GO:0008284 IEA:Ensembl P positive regulation of cell proliferation
GO:0045666 IEA:Ensembl P positive regulation of neuron differentiation
GO:0045944 IEA:Ensembl P positive regulation of transcription from RNA polymerase II promoter
GO:0031641 IEA:Ensembl P regulation of myelination
GO:0003406 IEA:Ensembl P retinal pigment epithelium development
GO:0007165 TAS:ProtInc P signal transduction
GO:0021756 IEA:Ensembl P striatum development
GO:0006367 TAS:Reactome P transcription initiation from RNA polymerase II promoter
GO:0001657 IEA:Ensembl P ureteric bud development
GO:0055012 IEA:Ensembl P ventricular cardiac muscle cell differentiation

KEGG Pathway Links

KEGG Pathway ID Description
hsa05223 Non-small cell lung cancer

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR003078 Retinoic acid receptor
IPR001723 Steroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
retinoic acid receptor, beta
Protein Entry
F1D8S6_HUMAN
UniProt ID
Q86UC5
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=4; Name=Beta-1; IsoId=P10826-1; Sequence=Displayed; Name=Beta-2; IsoId=P10826-2; Sequence=VSP_003634; Name=Beta-3; IsoId=P10826-4; Sequence=Not described; Name=Beta-4; IsoId=P10826-3; Sequence=VSP_003635;
Disease Microphthalmia, syndromic, 12 (MCOPS12) [MIM
Domain Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Function Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.
Interaction P03255:- (xeno); NbExp=2; IntAct=EBI-8583223, EBI-2603114;
Sequence Caution Sequence=CAA27637.1; Type=Erroneous gene model prediction; Evidence= ;
Similarity Belongs to the nuclear hormone receptor family. NR1 subfamily.
Similarity Contains 1 nuclear receptor DNA-binding domain.
Subcellular Location Isoform Beta-1: Nucleus.
Subcellular Location Isoform Beta-2: Nucleus.
Subcellular Location Isoform Beta-4: Cytoplasm.
Subunit Homodimer (By similarity). Heterodimer; with a RXR molecule. Binds DNA preferentially as a RAR/RXR heterodimer (By similarity). Interacts weakly with NCOR2. {ECO

Identical and Related Proteins

Unique RefSeq proteins for LMP001867 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
14916494 RefSeq NP_000956 448 retinoic acid receptor beta isoform 1
590122018 RefSeq NP_001277146 336 retinoic acid receptor beta isoform 2
590122016 RefSeq NP_001277145 455 retinoic acid receptor beta isoform 3
590122018 RefSeq NP_001277195 336 retinoic acid receptor beta isoform 4

Identical Sequences to LMP001867 proteins

Reference Database Accession Length Protein Name
GI:14916494 GenBank AGD01417.1 448 Sequence 940 from patent US 8338124
GI:14916494 GenBank AHD74748.1 448 Sequence 14765 from patent US 8586006
GI:14916494 GenBank AIC49569.1 448 RARB, partial [synthetic construct]
GI:14916494 RefSeq XP_004033801.1 448 PREDICTED: retinoic acid receptor beta isoform 1 [Gorilla gorilla gorilla]
GI:590122016 RefSeq XP_005545685.1 455 PREDICTED: retinoic acid receptor beta isoform X1 [Macaca fascicularis]
GI:14916494 RefSeq XP_005545686.1 448 PREDICTED: retinoic acid receptor beta isoform X2 [Macaca fascicularis]
GI:590122018 RefSeq NP_001277205.1 336 retinoic acid receptor beta isoform 2 [Homo sapiens]
GI:590122018 RefSeq NP_001277205.1 336 retinoic acid receptor beta isoform 2 [Homo sapiens]
GI:590122018 RefSeq XP_009200069.1 336 PREDICTED: retinoic acid receptor beta isoform X2 [Papio anubis]
GI:590122018 RefSeq XP_009200069.1 336 PREDICTED: retinoic acid receptor beta isoform X2 [Papio anubis]
GI:590122018 RefSeq XP_009200070.1 336 PREDICTED: retinoic acid receptor beta isoform X2 [Papio anubis]
GI:590122018 RefSeq XP_009200070.1 336 PREDICTED: retinoic acid receptor beta isoform X2 [Papio anubis]
GI:590122016 RefSeq XP_009443303.1 455 PREDICTED: retinoic acid receptor beta isoform X1 [Pan troglodytes]
GI:590122018 RefSeq XP_009443304.1 336 PREDICTED: retinoic acid receptor beta isoform X3 [Pan troglodytes]
GI:590122018 RefSeq XP_009443304.1 336 PREDICTED: retinoic acid receptor beta isoform X3 [Pan troglodytes]
GI:590122018 RefSeq XP_009443305.1 336 PREDICTED: retinoic acid receptor beta isoform X3 [Pan troglodytes]
GI:590122018 RefSeq XP_009443305.1 336 PREDICTED: retinoic acid receptor beta isoform X3 [Pan troglodytes]
GI:590122018 RefSeq XP_009443306.1 336 PREDICTED: retinoic acid receptor beta isoform X3 [Pan troglodytes]
GI:590122018 RefSeq XP_009443306.1 336 PREDICTED: retinoic acid receptor beta isoform X3 [Pan troglodytes]
GI:14916494 RefSeq XP_010356303.1 448 PREDICTED: retinoic acid receptor beta [Rhinopithecus roxellana]
GI:590122016 SwissProt P10826.2 455 RecName: Full=Retinoic acid receptor beta; Short=RAR-beta; AltName: Full=HBV-activated protein; AltName: Full=Nuclear receptor subfamily 1 group B member 2; AltName: Full=RAR-epsilon [Homo sapiens]

Related Sequences to LMP001867 proteins

Reference Database Accession Length Protein Name
GI:14916494 DBBJ BAF84721.1 448 unnamed protein product [Homo sapiens]
GI:590122018 DBBJ BAJ20818.1 448 retinoic acid receptor, beta, partial [synthetic construct]
GI:590122018 DBBJ BAJ20818.1 448 retinoic acid receptor, beta, partial [synthetic construct]
GI:14916494 GenBank AAQ70359.1 448 Sequence 2 from patent US 5223606
GI:14916494 GenBank ACM83441.1 459 Sequence 8939 from patent US 6812339
GI:14916494 GenBank ACM83442.1 459 Sequence 8940 from patent US 6812339
GI:14916494 pat WO 448 Sequence 9 from Patent WO 8905854
GI:14916494 PRF - 448 retinoic acid receptor [Homo sapiens]
GI:590122018 PRF - 448 retinoic acid receptor [Homo sapiens]
GI:590122018 PRF - 448 retinoic acid receptor [Homo sapiens]
GI:590122016 RefSeq XP_002716265.1 455 PREDICTED: retinoic acid receptor beta isoform X1 [Oryctolagus cuniculus]
GI:590122016 RefSeq XP_005387545.1 455 PREDICTED: retinoic acid receptor beta isoform X2 [Chinchilla lanigera]
GI:590122018 RefSeq XP_005545685.1 455 PREDICTED: retinoic acid receptor beta isoform X1 [Macaca fascicularis]
GI:590122018 RefSeq XP_005545685.1 455 PREDICTED: retinoic acid receptor beta isoform X1 [Macaca fascicularis]
GI:590122016 RefSeq XP_006153384.1 455 PREDICTED: retinoic acid receptor beta isoform X1 [Tupaia chinensis]
GI:590122018 RefSeq NP_001277145.1 455 retinoic acid receptor beta isoform 3 [Homo sapiens]
GI:590122018 RefSeq NP_001277145.1 455 retinoic acid receptor beta isoform 3 [Homo sapiens]
GI:590122016 RefSeq XP_008007485.1 455 PREDICTED: retinoic acid receptor beta isoform X1 [Chlorocebus sabaeus]
GI:590122016 RefSeq XP_008516546.1 455 PREDICTED: retinoic acid receptor beta isoform X1 [Equus przewalskii]
GI:590122018 RefSeq XP_009443303.1 455 PREDICTED: retinoic acid receptor beta isoform X1 [Pan troglodytes]
GI:590122018 RefSeq XP_009443303.1 455 PREDICTED: retinoic acid receptor beta isoform X1 [Pan troglodytes]
GI:590122016 RefSeq XP_010344847.1 455 PREDICTED: retinoic acid receptor beta isoform X1 [Saimiri boliviensis boliviensis]
GI:590122018 SwissProt P10826.2 455 RecName: Full=Retinoic acid receptor beta; Short=RAR-beta; AltName: Full=HBV-activated protein; AltName: Full=Nuclear receptor subfamily 1 group B member 2; AltName: Full=RAR-epsilon [Homo sapiens]
GI:590122018 SwissProt P10826.2 455 RecName: Full=Retinoic acid receptor beta; Short=RAR-beta; AltName: Full=HBV-activated protein; AltName: Full=Nuclear receptor subfamily 1 group B member 2; AltName: Full=RAR-epsilon [Homo sapiens]