Gene/Proteome Database (LMPD)
LMPD ID
LMP001868
Gene ID
Species
Homo sapiens (Human)
Gene Name
inositol polyphosphate-4-phosphatase, type II, 105kDa
Gene Symbol
Synonyms
-
Alternate Names
type II inositol 3,4-bisphosphate 4-phosphatase; inositol polyphosphate 4-phosphatase type II; type II inositol-3,4-bisphosphate 4-phosphatase; inositol polyphosphate-4-phosphatase, type II, 105kD; inositol polyphosphate 4-phosphatase II; 4-phosphatase II
Chromosome
4
Map Location
4q31.21
EC Number
3.1.3.66
Summary
INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| type II inositol 3,4-bisphosphate 4-phosphatase | |
|---|---|
| Refseq ID | NP_003857 |
| Protein GI | 156104895 |
| UniProt ID | O15327 |
| mRNA ID | NM_003866 |
| Length | 924 |
| RefSeq Status | REVIEWED |
| MEIKEEGASEEGQHFLPTAQANDPGDCQFTSIQKTPNEPQLEFILACKDLVAPVRDRKLNTLVQISVIHPVEQSLTRYSSTEIVEGTRDPLFLTGVTFPSEYPIYEETKIKLTVYDVKDKSHDTVRTSVLPEHKDPPPEVGRSFLGYASFKVGELLKSKEQLLVLSLRTSDGGKVVGTIEVSVVKMGEIEDGEADHITTDVQGQKCALVCECTAPESVSGKDNLPFLNSVLKNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIKEDLCRNQEIKELGELSPHWDNLRKNVLTHCDQMVNMYQDILTELSKETGSSFKSSSSKGEKTLEFVPINLHLQRMQVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETERRNTGYQFIYYSPENTAKAKEVLSNINQLQPLIATHADLLLNSASQHSPDSLKNSLKMLSEKTELFVHAFKDQLVRSALLALYTARPGGILKKPPSPKSSTEESSPQDQPPVMRGQDSIPHHSDYDEEEWDRVWANVGKSLNCIIAMVDKLIERDGGSEGSGGNNDGEKEPSLTDAIPSHPREDWYEQLYPLILTLKDCMGEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRRDIVFSQALAGLVCGFIIKLQTSLYDPGFLQQLHTVGLIVQYEGLLSTYSDEIGMLEDMAVGISDLKKVAFKIIEAKSNDVLPVITGRREHYVVEVKLPARMFESLPLQIKEGQLLHVYPVLFNVGINEQQTLAERFGDVSLQESINQENFELLQEYYKIFMEKMPPDYISHFQEQNDLKALLENLLQNIQSKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRREGCRIENVLKNIKCRKYAFNMLQLMAFPKYYRPPEGTYGKADT | |
| type II inositol 3,4-bisphosphate 4-phosphatase | |
|---|---|
| Refseq ID | NP_001095139 |
| Protein GI | 156104897 |
| UniProt ID | O15327 |
| mRNA ID | NM_001101669 |
| Length | 924 |
| RefSeq Status | REVIEWED |
| Protein sequence is identical to GI:156104895 (mRNA isoform) | |
Gene Information
Entrez Gene ID
Gene Name
inositol polyphosphate-4-phosphatase, type II, 105kDa
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005794 | IEA:Ensembl | C | Golgi apparatus |
| GO:0005829 | TAS:Reactome | C | cytosol |
| GO:0008289 | IEA:Ensembl | F | lipid binding |
| GO:0034594 | IEA:Ensembl | F | phosphatidylinositol trisphosphate phosphatase activity |
| GO:0016316 | TAS:ProtInc | F | phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity |
| GO:0034597 | IEA:UniProtKB-EC | F | phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity |
| GO:0006874 | IEA:Ensembl | P | cellular calcium ion homeostasis |
| GO:0043647 | TAS:Reactome | P | inositol phosphate metabolic process |
| GO:0045671 | IEA:Ensembl | P | negative regulation of osteoclast differentiation |
| GO:0006661 | TAS:Reactome | P | phosphatidylinositol biosynthetic process |
| GO:0006644 | TAS:Reactome | P | phospholipid metabolic process |
| GO:0046850 | IEA:Ensembl | P | regulation of bone remodeling |
| GO:0046822 | IEA:Ensembl | P | regulation of nucleocytoplasmic transport |
| GO:0051896 | IEA:Ensembl | P | regulation of protein kinase B signaling |
| GO:0007165 | TAS:ProtInc | P | signal transduction |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_150352 | Synthesis of IP2, IP, and Ins in the cytosol |
| REACT_120756 | Synthesis of PIPs at the early endosome membrane |
| REACT_121025 | Synthesis of PIPs at the plasma membrane |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR000008 | C2 domain |
UniProt Annotations
Entry Information
Gene Name
inositol polyphosphate-4-phosphatase, type II, 105kDa
Protein Entry
INP4B_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O15327-1; Sequence=Displayed; Name=2; Synonyms=stubby; IsoId=O15327-2; Sequence=VSP_047696, VSP_047697; |
| Catalytic Activity | 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate. |
| Enzyme Regulation | Strongly inhibited by inositol hexakisphosphate. |
| Function | Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 1,4-bisphosphate. |
| Pathway | Signal transduction; phosphatidylinositol signaling pathway. |
| Sequence Caution | Sequence=AAH72447.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence= ; |
| Similarity | Belongs to the inositol 3,4-bisphosphate 4-phosphatase family. |
| Similarity | Contains 1 C2 domain. |
| Tissue Specificity | Widely expressed with highest levels occurring in the skeletal muscle and heart. |
Identical and Related Proteins
Unique RefSeq proteins for LMP001868 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 156104895 | RefSeq | NP_003857 | 924 | type II inositol 3,4-bisphosphate 4-phosphatase |
Identical Sequences to LMP001868 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:156104895 | GenBank | AAI10919.1 | 924 | Inositol polyphosphate-4-phosphatase, type II, 105kDa [Homo sapiens] |
| GI:156104895 | GenBank | EAX05081.1 | 924 | inositol polyphosphate-4-phosphatase, type II, 105kDa [Homo sapiens] |
| GI:156104895 | GenBank | AAI33006.1 | 924 | Inositol polyphosphate-4-phosphatase, type II, 105kDa [Homo sapiens] |
| GI:156104895 | RefSeq | NP_001095139.1 | 924 | type II inositol 3,4-bisphosphate 4-phosphatase [Homo sapiens] |
| GI:156104895 | RefSeq | XP_006714465.1 | 924 | PREDICTED: type II inositol 3,4-bisphosphate 4-phosphatase isoform X7 [Homo sapiens] |
| GI:156104895 | SwissProt | O15327.4 | 924 | RecName: Full=Type II inositol 3,4-bisphosphate 4-phosphatase; AltName: Full=Inositol polyphosphate 4-phosphatase type II [Homo sapiens] |
Related Sequences to LMP001868 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:156104895 | GenBank | AAB72153.1 | 924 | inositol polyphosphate 4-phosphatase type II-alpha [Homo sapiens] |
| GI:156104895 | GenBank | ACQ12345.1 | 924 | Sequence 26 from patent US 7507536 |
| GI:156104895 | RefSeq | XP_001142120.1 | 924 | PREDICTED: type II inositol 3,4-bisphosphate 4-phosphatase isoform X4 [Pan troglodytes] |
| GI:156104895 | RefSeq | XP_004040470.1 | 924 | PREDICTED: type II inositol 3,4-bisphosphate 4-phosphatase isoform 1 [Gorilla gorilla gorilla] |
| GI:156104895 | RefSeq | XP_004040471.1 | 924 | PREDICTED: type II inositol 3,4-bisphosphate 4-phosphatase isoform 2 [Gorilla gorilla gorilla] |
| GI:156104895 | RefSeq | XP_008972380.1 | 924 | PREDICTED: type II inositol 3,4-bisphosphate 4-phosphatase [Pan paniscus] |