Gene/Proteome Database (LMPD)

LMPD ID
LMP001889
Gene ID
10062
Species
Homo sapiens (Human)
Gene Name
nuclear receptor subfamily 1, group H, member 3
Gene Symbol
NR1H3
Synonyms
LXR-a; LXRA; RLD-1
Chromosome
11
Map Location
11p11.2
Summary
The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Orthologs
View orthologs and multiple alignments for NR1H3

Proteins

oxysterols receptor LXR-alpha isoform 1
Refseq ID NP_005684
Protein GI 194294517
UniProt ID Q13133
mRNA ID NM_005693
Length 447
RefSeq Status REVIEWED
MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
oxysterols receptor LXR-alpha isoform 2
Refseq ID NP_001123573
Protein GI 194328806
UniProt ID Q13133
mRNA ID NM_001130101
Length 387
RefSeq Status REVIEWED
MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
oxysterols receptor LXR-alpha isoform 3
Refseq ID NP_001123574
Protein GI 194294519
UniProt ID Q13133
mRNA ID NM_001130102
Length 402
RefSeq Status REVIEWED
MPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
oxysterols receptor LXR-alpha isoform 4
Refseq ID NP_001238863
Protein GI 353731058
UniProt ID B4DXU5
mRNA ID NM_001251934
Length 453
RefSeq Status REVIEWED
MQQTSWNPLGGTCKQPPGRTHSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
oxysterols receptor LXR-alpha isoform 4
Refseq ID NP_001238864
Protein GI 353731060
UniProt ID B4DXU5
mRNA ID NM_001251935
Length 453
RefSeq Status REVIEWED
Protein sequence is identical to GI:353731058 (mRNA isoform)

Gene Information

Entrez Gene ID
10062
Gene Name
nuclear receptor subfamily 1, group H, member 3
Gene Symbol
NR1H3
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0000790 IDA:BHF-UCL C nuclear chromatin
GO:0005654 TAS:Reactome C nucleoplasm
GO:0005634 TAS:ProtInc C nucleus
GO:0003677 TAS:ProtInc F DNA binding
GO:0000978 IEA:Ensembl F RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IEA:Ensembl F RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0015485 TAS:BHF-UCL F cholesterol binding
GO:0004879 TAS:ProtInc F ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0032810 IDA:UniProtKB F sterol response element binding
GO:0003713 TAS:ProtInc F transcription coactivator activity
GO:0044212 IDA:BHF-UCL F transcription regulatory region DNA binding
GO:0008270 IEA:InterPro F zinc ion binding
GO:0043277 IMP:UniProtKB P apoptotic cell clearance
GO:0044255 IEA:Ensembl P cellular lipid metabolic process
GO:0071222 IDA:BHF-UCL P cellular response to lipopolysaccharide
GO:0042632 ISS:BHF-UCL P cholesterol homeostasis
GO:0010467 TAS:Reactome P gene expression
GO:0055088 ISS:BHF-UCL P lipid homeostasis
GO:0010887 IMP:BHF-UCL P negative regulation of cholesterol storage
GO:0050728 ISS:BHF-UCL P negative regulation of inflammatory response
GO:0060336 NAS:BHF-UCL P negative regulation of interferon-gamma-mediated signaling pathway
GO:0032369 IMP:BHF-UCL P negative regulation of lipid transport
GO:0043031 ISS:BHF-UCL P negative regulation of macrophage activation
GO:0010745 IC:BHF-UCL P negative regulation of macrophage derived foam cell differentiation
GO:0090188 ISS:BHF-UCL P negative regulation of pancreatic juice secretion
GO:0048550 IMP:BHF-UCL P negative regulation of pinocytosis
GO:0045861 IEA:Ensembl P negative regulation of proteolysis
GO:0090341 ISS:BHF-UCL P negative regulation of secretion of lysosomal enzymes
GO:0000122 ISS:BHF-UCL P negative regulation of transcription from RNA polymerase II promoter
GO:0032270 IMP:BHF-UCL P positive regulation of cellular protein metabolic process
GO:0010875 IDA:BHF-UCL P positive regulation of cholesterol efflux
GO:2000189 IDA:BHF-UCL P positive regulation of cholesterol homeostasis
GO:0032376 IDA:BHF-UCL P positive regulation of cholesterol transport
GO:0045723 IMP:BHF-UCL P positive regulation of fatty acid biosynthetic process
GO:0051006 IMP:BHF-UCL P positive regulation of lipoprotein lipase activity
GO:0010870 IDA:BHF-UCL P positive regulation of receptor biosynthetic process
GO:0034145 IDA:BHF-UCL P positive regulation of toll-like receptor 4 signaling pathway
GO:0045944 IDA:UniProtKB P positive regulation of transcription from RNA polymerase II promoter
GO:0045893 IMP:UniProtKB P positive regulation of transcription, DNA-templated
GO:0010867 IMP:BHF-UCL P positive regulation of triglyceride biosynthetic process
GO:2000188 ISS:UniProtKB P regulation of cholesterol homeostasis
GO:0042752 TAS:BHF-UCL P regulation of circadian rhythm
GO:0032570 IDA:BHF-UCL P response to progesterone
GO:0055092 ISS:BHF-UCL P sterol homeostasis
GO:0006367 TAS:Reactome P transcription initiation from RNA polymerase II promoter
GO:0070328 ISS:BHF-UCL P triglyceride homeostasis

KEGG Pathway Links

KEGG Pathway ID Description
hsa04932 Non-alcoholic fatty liver disease (NAFLD)

Domain Information

InterPro Annotations

Accession Description
IPR023257 Liver X receptor
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001723 Steroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
nuclear receptor subfamily 1, group H, member 3
Protein Entry
B4DXU5_HUMAN
UniProt ID
Q13133
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q13133-1; Sequence=Displayed; Name=2; IsoId=Q13133-2; Sequence=VSP_003664; Note=No experimental confirmation available.; Name=3; IsoId=Q13133-3; Sequence=VSP_044960; Note=No experimental confirmation available.;
Function Nuclear receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half- sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity).
Induction By 9-cis retinoic acid (9CRA).
Interaction O60869:EDF1; NbExp=4; IntAct=EBI-781356, EBI-781301; O60341:KDM1A; NbExp=2; IntAct=EBI-781356, EBI-710124; Q15788:NCOA1; NbExp=14; IntAct=EBI-781356, EBI-455189; O43463:SUV39H1; NbExp=2; IntAct=EBI-781356, EBI-349968;
Similarity Belongs to the nuclear hormone receptor family. NR1 subfamily.
Similarity Contains 1 nuclear receptor DNA-binding domain.
Subcellular Location Nucleus {ECO
Subunit Heterodimer of LXRA and RXR.
Tissue Specificity Visceral organs specific expression. Strong expression was found in liver, kidney and intestine followed by spleen and to a lesser extent the adrenals.

Identical and Related Proteins

Unique RefSeq proteins for LMP001889 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
194294517 RefSeq NP_005684 447 oxysterols receptor LXR-alpha isoform 1
194328806 RefSeq NP_001123573 387 oxysterols receptor LXR-alpha isoform 2
194294519 RefSeq NP_001123574 402 oxysterols receptor LXR-alpha isoform 3
353731058 RefSeq NP_001238863 453 oxysterols receptor LXR-alpha isoform 4

Identical Sequences to LMP001889 proteins

Reference Database Accession Length Protein Name
GI:353731058 DBBJ BAG63507.1 453 unnamed protein product [Homo sapiens]
GI:194328806 GenBank ACE87408.1 387 nuclear receptor subfamily 1, group H, member 3 protein [synthetic construct]
GI:194328806 GenBank AIC50490.1 387 NR1H3, partial [synthetic construct]
GI:353731058 RefSeq NP_001238864.1 453 oxysterols receptor LXR-alpha isoform 4 [Homo sapiens]
GI:194328806 RefSeq XP_003815235.1 387 PREDICTED: oxysterols receptor LXR-alpha isoform X3 [Pan paniscus]
GI:194328806 RefSeq XP_005252770.1 387 PREDICTED: oxysterols receptor LXR-alpha isoform X10 [Homo sapiens]
GI:194294517 RefSeq XP_008966358.1 447 PREDICTED: oxysterols receptor LXR-alpha isoform X1 [Pan paniscus]
GI:194294519 RefSeq XP_008966360.1 402 PREDICTED: oxysterols receptor LXR-alpha isoform X2 [Pan paniscus]
GI:194294519 RefSeq XP_008966361.1 402 PREDICTED: oxysterols receptor LXR-alpha isoform X2 [Pan paniscus]
GI:194328806 RefSeq XP_008966362.1 387 PREDICTED: oxysterols receptor LXR-alpha isoform X3 [Pan paniscus]
GI:194294517 RefSeq XP_009458620.1 447 PREDICTED: oxysterols receptor LXR-alpha isoform X1 [Pan troglodytes]
GI:194294517 RefSeq XP_009458621.1 447 PREDICTED: oxysterols receptor LXR-alpha isoform X1 [Pan troglodytes]
GI:194294517 RefSeq XP_009458622.1 447 PREDICTED: oxysterols receptor LXR-alpha isoform X1 [Pan troglodytes]
GI:194294517 RefSeq XP_009458623.1 447 PREDICTED: oxysterols receptor LXR-alpha isoform X1 [Pan troglodytes]
GI:194294517 RefSeq XP_009458624.1 447 PREDICTED: oxysterols receptor LXR-alpha isoform X1 [Pan troglodytes]
GI:194294519 RefSeq XP_009458625.1 402 PREDICTED: oxysterols receptor LXR-alpha isoform X2 [Pan troglodytes]
GI:194294519 RefSeq XP_009458627.1 402 PREDICTED: oxysterols receptor LXR-alpha isoform X2 [Pan troglodytes]
GI:194294519 RefSeq XP_009458628.1 402 PREDICTED: oxysterols receptor LXR-alpha isoform X2 [Pan troglodytes]
GI:194328806 RefSeq XP_009458629.1 387 PREDICTED: oxysterols receptor LXR-alpha isoform X3 [Pan troglodytes]
GI:194294519 RefSeq XP_009458631.1 402 PREDICTED: oxysterols receptor LXR-alpha isoform X2 [Pan troglodytes]
GI:353731058 RefSeq XP_009458632.1 453 PREDICTED: oxysterols receptor LXR-alpha isoform X5 [Pan troglodytes]

Related Sequences to LMP001889 proteins

Reference Database Accession Length Protein Name
GI:194294519 DBBJ BAG73455.1 447 nuclear receptor subfamily 1, group H, member 3, partial [synthetic construct]
GI:194294517 GenBank AAV38217.1 448 nuclear receptor subfamily 1, group H, member 3, partial [synthetic construct]
GI:194294517 GenBank AAX36204.1 448 nuclear receptor subfamily 1 group H member 3, partial [synthetic construct]
GI:194294517 GenBank AAX36811.1 448 nuclear receptor subfamily 1 group H member 3, partial [synthetic construct]
GI:194294519 GenBank AAX41536.1 447 nuclear receptor subfamily 1 group H member 3 [synthetic construct]
GI:194294517 GenBank AAX43168.1 448 nuclear receptor subfamily 1 group H member 3, partial [synthetic construct]
GI:194294517 GenBank ACM82560.1 453 Sequence 8058 from patent US 6812339
GI:194294517 GenBank ACM82915.1 453 Sequence 8413 from patent US 6812339
GI:353731058 GenBank EHH22939.1 453 hypothetical protein EGK_06297 [Macaca mulatta]
GI:194328806 RefSeq XP_001108542.1 387 PREDICTED: oxysterols receptor LXR-alpha isoform 1 [Macaca mulatta]
GI:353731058 RefSeq XP_003279016.1 453 PREDICTED: oxysterols receptor LXR-alpha isoform 3 [Nomascus leucogenys]
GI:194328806 RefSeq XP_003279017.1 387 PREDICTED: oxysterols receptor LXR-alpha isoform 4 [Nomascus leucogenys]
GI:194328806 RefSeq XP_004051092.1 387 PREDICTED: oxysterols receptor LXR-alpha isoform 2 [Gorilla gorilla gorilla]
GI:353731058 RefSeq XP_004051094.1 453 PREDICTED: oxysterols receptor LXR-alpha isoform 4 [Gorilla gorilla gorilla]
GI:353731058 RefSeq XP_004051095.1 453 PREDICTED: oxysterols receptor LXR-alpha isoform 5 [Gorilla gorilla gorilla]
GI:194328806 RefSeq XP_004090759.1 387 PREDICTED: oxysterols receptor LXR-alpha [Nomascus leucogenys]
GI:353731058 RefSeq XP_004090760.1 453 PREDICTED: oxysterols receptor LXR-alpha [Nomascus leucogenys]
GI:194328806 RefSeq XP_005252762.1 447 PREDICTED: oxysterols receptor LXR-alpha isoform X2 [Homo sapiens]
GI:194294519 RefSeq XP_005252762.1 447 PREDICTED: oxysterols receptor LXR-alpha isoform X2 [Homo sapiens]
GI:194328806 RefSeq XP_005252763.1 447 PREDICTED: oxysterols receptor LXR-alpha isoform X3 [Homo sapiens]
GI:194294519 RefSeq XP_005252763.1 447 PREDICTED: oxysterols receptor LXR-alpha isoform X3 [Homo sapiens]
GI:194294519 RefSeq XP_005252764.1 447 PREDICTED: oxysterols receptor LXR-alpha isoform X4 [Homo sapiens]
GI:194294519 RefSeq XP_006718175.1 447 PREDICTED: oxysterols receptor LXR-alpha isoform X16 [Homo sapiens]
GI:353731058 RefSeq XP_007997986.1 453 PREDICTED: oxysterols receptor LXR-alpha isoform X4 [Chlorocebus sabaeus]