Gene/Proteome Database (LMPD)

LMPD ID
LMP001896
Gene ID
6462
Species
Homo sapiens (Human)
Gene Name
sex hormone-binding globulin
Gene Symbol
SHBG
Synonyms
ABP; SBP; TEBG
Chromosome
17
Map Location
17p13.1
Summary
This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein transports androgens and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical monomers. Polymorphisms in this gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Orthologs
View orthologs and multiple alignments for SHBG

Proteins

sex hormone-binding globulin isoform 1 precursor
Refseq ID NP_001031
Protein GI 7382460
UniProt ID P04278
mRNA ID NM_001040
Length 402
RefSeq Status REVIEWED
MESRGPLATSRLLLLLLLLLLRHTRQGWALRPVLPTQSAHDPPAVHLSNGPGQEPIAVMTFDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGLRDGRPEIQLHNHWAQLTVGAGPRLDDGRWHQVEVKMEGDSVLLEVDGEEVLRLRQVSGPLTSKRHPIMRIALGGLLFPASNLRLPLVPALDGCLRRDSWLDKQAEISASAPTSLRSCDVESNPGIFLPPGTQAEFNLRDIPQPHAEPWAFSLDLGLKQAAGSGHLLALGTPENPSWLSLHLQDQKVVLSSGSGPGLDLPLVLGLPLQLKLSMSRVVLSQGSKMKALALPPLGLAPLLNLWAKPQGRLFLGALPGEDSSTSFCLNGLWAQGQRLDVDQALNRSHEIWTHSCPQSPGNGTDASH
sex hormone-binding globulin isoform 2 precursor
Refseq ID NP_001139751
Protein GI 7382460
UniProt ID P04278
mRNA ID NM_001146279
Length 402
RefSeq Status REVIEWED
MESRGPLATSRLLLLLLLLLLRHTRQGWALRPVLPTQSAHDPPAVHLSNGPGQEPIAVMTFDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGLRDGRPEIQLHNHWAQLTVGAGPRLDDGRWHQVEVKMEGDSVLLEVDGEEVLRLRQVSGPLTSKRHPIMRIALGGLLFPASNLRLPLVPALDGCLRRDSWLDKQAEISASAPTSLRSCDVESNPGIFLPPGTQAEFNLRDIPQPHAEPWAFSLDLGLKQAAGSGHLLALGTPENPSWLSLHLQDQKVVLSSGSGPGLDLPLVLGLPLQLKLSMSRVVLSQGSKMKALALPPLGLAPLLNLWAKPQGRLFLGALPGEDSSTSFCLNGLWAQGQRLDVDQALNRSHEIWTHSCPQSPGNGTDASH
sex hormone-binding globulin isoform 3 precursor
Refseq ID NP_001139752
Protein GI 7382460
UniProt ID P04278
mRNA ID NM_001146280
Length 402
RefSeq Status REVIEWED
MESRGPLATSRLLLLLLLLLLRHTRQGWALRPVLPTQSAHDPPAVHLSNGPGQEPIAVMTFDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGLRDGRPEIQLHNHWAQLTVGAGPRLDDGRWHQVEVKMEGDSVLLEVDGEEVLRLRQVSGPLTSKRHPIMRIALGGLLFPASNLRLPLVPALDGCLRRDSWLDKQAEISASAPTSLRSCDVESNPGIFLPPGTQAEFNLRDIPQPHAEPWAFSLDLGLKQAAGSGHLLALGTPENPSWLSLHLQDQKVVLSSGSGPGLDLPLVLGLPLQLKLSMSRVVLSQGSKMKALALPPLGLAPLLNLWAKPQGRLFLGALPGEDSSTSFCLNGLWAQGQRLDVDQALNRSHEIWTHSCPQSPGNGTDASH
sex hormone-binding globulin isoform 4 precursor
Refseq ID NP_001139753
Protein GI 7382460
UniProt ID P04278
mRNA ID NM_001146281
Length 402
RefSeq Status REVIEWED
MESRGPLATSRLLLLLLLLLLRHTRQGWALRPVLPTQSAHDPPAVHLSNGPGQEPIAVMTFDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGLRDGRPEIQLHNHWAQLTVGAGPRLDDGRWHQVEVKMEGDSVLLEVDGEEVLRLRQVSGPLTSKRHPIMRIALGGLLFPASNLRLPLVPALDGCLRRDSWLDKQAEISASAPTSLRSCDVESNPGIFLPPGTQAEFNLRDIPQPHAEPWAFSLDLGLKQAAGSGHLLALGTPENPSWLSLHLQDQKVVLSSGSGPGLDLPLVLGLPLQLKLSMSRVVLSQGSKMKALALPPLGLAPLLNLWAKPQGRLFLGALPGEDSSTSFCLNGLWAQGQRLDVDQALNRSHEIWTHSCPQSPGNGTDASH
sex hormone-binding globulin isoform 5
Refseq ID NP_001276042
Protein GI 574287849
UniProt ID P04278
mRNA ID NM_001289113
Length 344
RefSeq Status REVIEWED
MTFDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGLRDGRPEIQLHNHWAQLTVGAGPRLDDGRWHQVEVKMEGDSVLLEVDGEEVLRLRQVSGPLTSKRHPIMRIALGGLLFPASNLRLPLVPALDGCLRRDSWLDKQAEISASAPTSLRSCDVESNPGIFLPPGTQAEFNLRDIPQPHAEPWAFSLDLGLKQAAGSGHLLALGTPENPSWLSLHLQDQKVVLSSGSGPGLDLPLVLGLPLQLKLSMSRVVLSQGSKMKALALPPLGLAPLLNLWAKPQGRLFLGALPGEDSSTSFCLNGLWAQGQRLDVDQALNRSHEIWTHSCPQSPGNGTDASH
sex hormone-binding globulin isoform 5
Refseq ID NP_001276043
Protein GI 574287947
UniProt ID P04278
mRNA ID NM_001289114
Length 344
RefSeq Status REVIEWED
Protein sequence is identical to GI:574287849 (mRNA isoform)
sex hormone-binding globulin isoform 6
Refseq ID NP_001276044
Protein GI 574288150
UniProt ID P04278
mRNA ID NM_001289115
Length 235
RefSeq Status REVIEWED
MTFDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGLRDGRPEIQLHNHWAQLTVGAGPRLDDGRWHQVEVKMEGDSVLLEVDGEEVLRLRQVSGPLTSKRHPIMRIALGGLLFPASNLRLPLVPALDGCLRRDSWLDKQAEISASAPTSLRSCDVESNPGIFLPPGTQAEFNLRDIPQPHAEPWAFSLDLGLKQAAGSGHLLALGTPENPSWLSLHLQDQEKTLPPLFA
sex hormone-binding globulin isoform 7
Refseq ID NP_001276045
Protein GI 574288150
UniProt ID P04278
mRNA ID NM_001289116
Length 235
RefSeq Status REVIEWED
MTFDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGLRDGRPEIQLHNHWAQLTVGAGPRLDDGRWHQVEVKMEGDSVLLEVDGEEVLRLRQVSGPLTSKRHPIMRIALGGLLFPASNLRLPLVPALDGCLRRDSWLDKQAEISASAPTSLRSCDVESNPGIFLPPGTQAEFNLRDIPQPHAEPWAFSLDLGLKQAAGSGHLLALGTPENPSWLSLHLQDQEKTLPPLFA
sig_peptide: 1..29 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 3329 peptide sequence: MESRGPLATSRLLLLLLLLLLRHTRQGWA mat_peptide: 30..402 product: Sex hormone-binding globulin experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P04278.2) calculated_mol_wt: 40468 peptide sequence: LRPVLPTQSAHDPPAVHLSNGPGQEPIAVMTFDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGLRDGRPEIQLHNHWAQLTVGAGPRLDDGRWHQVEVKMEGDSVLLEVDGEEVLRLRQVSGPLTSKRHPIMRIALGGLLFPASNLRLPLVPALDGCLRRDSWLDKQAEISASAPTSLRSCDVESNPGIFLPPGTQAEFNLRDIPQPHAEPWAFSLDLGLKQAAGSGHLLALGTPENPSWLSLHLQDQKVVLSSGSGPGLDLPLVLGLPLQLKLSMSRVVLSQGSKMKALALPPLGLAPLLNLWAKPQGRLFLGALPGEDSSTSFCLNGLWAQGQRLDVDQALNRSHEIWTHSCPQSPGNGTDASH sig_peptide: 1..29 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 3329 peptide sequence: MESRGPLATSRLLLLLLLLLLRHTRQGWA sig_peptide: 1..29 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 3329 peptide sequence: MESRGPLATSRLLLLLLLLLLRHTRQGWA sig_peptide: 1..29 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 3329 peptide sequence: MESRGPLATSRLLLLLLLLLLRHTRQGWA

Gene Information

Entrez Gene ID
6462
Gene Name
sex hormone-binding globulin
Gene Symbol
SHBG
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0007285 IEA:Ensembl P primary spermatocyte growth

Domain Information

InterPro Annotations

Accession Description
IPR013320 Concanavalin A-like lectin/glucanase domain
IPR001791 Laminin G domain

UniProt Annotations

Entry Information

Gene Name
sex hormone-binding globulin
Protein Entry
SHBG_HUMAN
UniProt ID
P04278
Species
Human

Identical and Related Proteins

Unique RefSeq proteins for LMP001896 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
7382460 RefSeq NP_001031 402 sex hormone-binding globulin isoform 1 precursor
7382460 RefSeq NP_001139751 402 sex hormone-binding globulin isoform 2 precursor
7382460 RefSeq NP_001139752 402 sex hormone-binding globulin isoform 3 precursor
7382460 RefSeq NP_001139753 402 sex hormone-binding globulin isoform 4 precursor
574287849 RefSeq NP_001276042 344 sex hormone-binding globulin isoform 5
574288150 RefSeq NP_001276044 235 sex hormone-binding globulin isoform 6
574288150 RefSeq NP_001276045 235 sex hormone-binding globulin isoform 7

Identical Sequences to LMP001896 proteins

Reference Database Accession Length Protein Name
GI:574288150 DBBJ BAG63852.1 235 unnamed protein product [Homo sapiens]
GI:574288150 DBBJ BAG63852.1 235 unnamed protein product [Homo sapiens]
GI:574287849 GenBank EAW90149.1 344 sex hormone-binding globulin, isoform CRA_a [Homo sapiens]
GI:574287849 GenBank ADA53556.1 344 Sequence 1386 from patent US 7625699
GI:7382460 GenBank ADS87580.1 402 Sequence 456 from patent US 7820380
GI:7382460 GenBank ADS87580.1 402 Sequence 456 from patent US 7820380
GI:7382460 GenBank ADS87580.1 402 Sequence 456 from patent US 7820380
GI:7382460 GenBank ADS87580.1 402 Sequence 456 from patent US 7820380
GI:574287849 GenBank ADS87581.1 344 Sequence 457 from patent US 7820380
GI:7382460 GenBank ADS87582.1 402 Sequence 458 from patent US 7820380
GI:7382460 GenBank ADS87582.1 402 Sequence 458 from patent US 7820380
GI:7382460 GenBank ADS87582.1 402 Sequence 458 from patent US 7820380
GI:7382460 GenBank ADS87582.1 402 Sequence 458 from patent US 7820380
GI:7382460 GenBank AEW40575.1 402 Sequence 456 from patent US 8071302
GI:7382460 GenBank AEW40575.1 402 Sequence 456 from patent US 8071302
GI:7382460 GenBank AEW40575.1 402 Sequence 456 from patent US 8071302
GI:7382460 GenBank AEW40575.1 402 Sequence 456 from patent US 8071302
GI:574287849 GenBank AEW40576.1 344 Sequence 457 from patent US 8071302
GI:7382460 GenBank AEW40577.1 402 Sequence 458 from patent US 8071302
GI:7382460 GenBank AEW40577.1 402 Sequence 458 from patent US 8071302
GI:7382460 GenBank AEW40577.1 402 Sequence 458 from patent US 8071302
GI:7382460 GenBank AEW40577.1 402 Sequence 458 from patent US 8071302
GI:7382460 GenBank AHD75314.1 402 Sequence 16593 from patent US 8586006
GI:7382460 GenBank AHD75314.1 402 Sequence 16593 from patent US 8586006
GI:7382460 GenBank AHD75314.1 402 Sequence 16593 from patent US 8586006
GI:7382460 GenBank AHD75314.1 402 Sequence 16593 from patent US 8586006
GI:7382460 GenBank AIC49722.1 402 SHBG, partial [synthetic construct]
GI:7382460 GenBank AIC49722.1 402 SHBG, partial [synthetic construct]
GI:7382460 GenBank AIC49722.1 402 SHBG, partial [synthetic construct]
GI:7382460 GenBank AIC49722.1 402 SHBG, partial [synthetic construct]
GI:574287849 RefSeq NP_001276043.1 344 sex hormone-binding globulin isoform 5 [Homo sapiens]

Related Sequences to LMP001896 proteins

Reference Database Accession Length Protein Name
GI:574288150 EMBL CAA34400.1 288 SHBG related protein (288 AA), partial [Homo sapiens]
GI:574288150 EMBL CAA34400.1 288 SHBG related protein (288 AA), partial [Homo sapiens]
GI:574287849 EMBL CAA34398.1 402 sex hormone-binding globulin (SHBG) [Homo sapiens]
GI:574287849 EMBL CAA29309.1 356 unnamed protein product [Homo sapiens]
GI:7382460 GenBank AAC18778.1 402 sex hormone-binding globulin [Homo sapiens]
GI:7382460 GenBank AAC18778.1 402 sex hormone-binding globulin [Homo sapiens]
GI:7382460 GenBank AAC18778.1 402 sex hormone-binding globulin [Homo sapiens]
GI:7382460 GenBank AAC18778.1 402 sex hormone-binding globulin [Homo sapiens]
GI:7382460 GenBank AAH69597.1 401 SHBG protein, partial [Homo sapiens]
GI:7382460 GenBank AAH69597.1 401 SHBG protein, partial [Homo sapiens]
GI:7382460 GenBank AAH69597.1 401 SHBG protein, partial [Homo sapiens]
GI:7382460 GenBank AAH69597.1 401 SHBG protein, partial [Homo sapiens]
GI:7382460 GenBank AAX36263.1 402 sex hormone-binding globulin [synthetic construct]
GI:7382460 GenBank AAX36263.1 402 sex hormone-binding globulin [synthetic construct]
GI:7382460 GenBank AAX36263.1 402 sex hormone-binding globulin [synthetic construct]
GI:7382460 GenBank AAX36263.1 402 sex hormone-binding globulin [synthetic construct]
GI:574288150 GenBank EAW90149.1 344 sex hormone-binding globulin, isoform CRA_a [Homo sapiens]
GI:574288150 GenBank EAW90149.1 344 sex hormone-binding globulin, isoform CRA_a [Homo sapiens]
GI:7382460 GenBank AEH97153.1 381 Sequence 3 from patent US 7947275
GI:7382460 GenBank AEH97153.1 381 Sequence 3 from patent US 7947275
GI:7382460 GenBank AEH97153.1 381 Sequence 3 from patent US 7947275
GI:7382460 GenBank AEH97153.1 381 Sequence 3 from patent US 7947275
GI:574287849 GenBank AEW40575.1 402 Sequence 456 from patent US 8071302
GI:574287849 GenBank AEW40577.1 402 Sequence 458 from patent US 8071302
GI:574287849 GenBank AIC49722.1 402 SHBG, partial [synthetic construct]
GI:574288150 RefSeq NP_001139752.1 293 sex hormone-binding globulin isoform 3 precursor [Homo sapiens]
GI:574288150 RefSeq NP_001139752.1 293 sex hormone-binding globulin isoform 3 precursor [Homo sapiens]
GI:7382460 RefSeq XP_003810120.1 402 PREDICTED: sex hormone-binding globulin isoform X1 [Pan paniscus]
GI:7382460 RefSeq XP_003810120.1 402 PREDICTED: sex hormone-binding globulin isoform X1 [Pan paniscus]
GI:7382460 RefSeq XP_003810120.1 402 PREDICTED: sex hormone-binding globulin isoform X1 [Pan paniscus]
GI:7382460 RefSeq XP_003810120.1 402 PREDICTED: sex hormone-binding globulin isoform X1 [Pan paniscus]
GI:574288150 RefSeq XP_003810121.1 293 PREDICTED: sex hormone-binding globulin isoform X2 [Pan paniscus]
GI:574288150 RefSeq XP_003810121.1 293 PREDICTED: sex hormone-binding globulin isoform X2 [Pan paniscus]
GI:7382460 RefSeq XP_004058546.1 405 PREDICTED: sex hormone-binding globulin isoform 1 [Gorilla gorilla gorilla]
GI:7382460 RefSeq XP_004058546.1 405 PREDICTED: sex hormone-binding globulin isoform 1 [Gorilla gorilla gorilla]
GI:7382460 RefSeq XP_004058546.1 405 PREDICTED: sex hormone-binding globulin isoform 1 [Gorilla gorilla gorilla]
GI:7382460 RefSeq XP_004058546.1 405 PREDICTED: sex hormone-binding globulin isoform 1 [Gorilla gorilla gorilla]
GI:574288150 RefSeq XP_004058547.1 296 PREDICTED: sex hormone-binding globulin isoform 2 [Gorilla gorilla gorilla]
GI:574288150 RefSeq XP_004058547.1 296 PREDICTED: sex hormone-binding globulin isoform 2 [Gorilla gorilla gorilla]
GI:574288150 RefSeq XP_008960681.1 235 PREDICTED: sex hormone-binding globulin isoform X5 [Pan paniscus]
GI:574288150 RefSeq XP_008960681.1 235 PREDICTED: sex hormone-binding globulin isoform X5 [Pan paniscus]
GI:574287849 SwissProt P04278.2 402 RecName: Full=Sex hormone-binding globulin; Short=SHBG; AltName: Full=Sex steroid-binding protein; Short=SBP; AltName: Full=Testis-specific androgen-binding protein; Short=ABP; AltName: Full=Testosterone-estradiol-binding globulin; Short=TeBG; AltName: Full=Testosterone-estrogen-binding globulin; Flags: Precursor [Homo sapiens]