Gene/Proteome Database (LMPD)

LMPD ID
LMP001921
Gene ID
1608
Species
Homo sapiens (Human)
Gene Name
diacylglycerol kinase, gamma 90kDa
Gene Symbol
DGKG
Synonyms
DAGK3; DGK-GAMMA
Alternate Names
diacylglycerol kinase gamma; DAG kinase gamma; diglyceride kinase gamma; diacylglyerol kinase gamma
Chromosome
3
Map Location
3q27.2-q27.3
EC Number
2.7.1.107
Summary
This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for DGKG

Proteins

diacylglycerol kinase gamma isoform 1
Refseq ID NP_001337
Protein GI 124256476
UniProt ID P49619
mRNA ID NM_001346
Length 791
RefSeq Status REVIEWED
MGEERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDPHEPISYDVFKLFMRAYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADTNIQNADNATKADEACAPDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGRPQDKLEFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYDRDGFVSLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSRNIPGCVKTYSKAKRSGEVMQHAWVEGNSSVKCDRCHKSIKCYQSVTARHCVWCRMTFHRKCELSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSAKGELVMQYKIIPTPGTHPLLVLVNPKSGGRQGERILRKFHYLLNPKQVFNLDNGGPTPGLNFFRDTPDFRVLACGGDGTVGWILDCIDKANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKDIEQSPLVMLDRWHLEVIPREEVENGDQVPYSIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASVTIRTNKLLPMQVDGEPWMQPCCTIKITHKNQAPMMMGPPQKSSFFSLRRKSRSKD
diacylglycerol kinase gamma isoform 2
Refseq ID NP_001074213
Protein GI 124256474
UniProt ID P49619
mRNA ID NM_001080744
Length 766
RefSeq Status REVIEWED
MGEERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDPHEPISYDVFKLFMRAYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADTNIQNADNATKADEACAPDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGRPQDKLEFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYDRDGFVSLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSRNIPGCVKTYSKAKRSGEVMQHAWVEGNSSVKCDRCHKSIKCYQSVTARHCVWCRMTFHRKCELSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSAKGELVMQYKIIPTPGTHPLLVLVNPKSGGRQGERLNFFRDTPDFRVLACGGDGTVGWILDCIDKANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKDIEQSPLVMLDRWHLEVIPREEVENGDQVPYSIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASVTIRTNKLLPMQVDGEPWMQPCCTIKITHKNQAPMMMGPPQKSSFFSLRRKSRSKD
diacylglycerol kinase gamma isoform 3
Refseq ID NP_001074214
Protein GI 124256474
UniProt ID P49619
mRNA ID NM_001080745
Length 766
RefSeq Status REVIEWED
MGEERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDPHEPISYDVFKLFMRAYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADTNIQNADNATKADEACAPDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGRPQDKLEFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYDRDGFVSLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSRNIPGCVKTYSKAKRSGEVMQHAWVEGNSSVKCDRCHKSIKCYQSVTARHCVWCRMTFHRKCELSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSAKGELVMQYKIIPTPGTHPLLVLVNPKSGGRQGERLNFFRDTPDFRVLACGGDGTVGWILDCIDKANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKDIEQSPLVMLDRWHLEVIPREEVENGDQVPYSIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASVTIRTNKLLPMQVDGEPWMQPCCTIKITHKNQAPMMMGPPQKSSFFSLRRKSRSKD

Gene Information

Entrez Gene ID
1608
Gene Name
diacylglycerol kinase, gamma 90kDa
Gene Symbol
DGKG
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0043231 IDA:HPA C intracellular membrane-bounded organelle
GO:0005886 IDA:HPA C plasma membrane
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0003951 IEA:InterPro F NAD+ kinase activity
GO:0005509 IEA:InterPro F calcium ion binding
GO:0004143 TAS:ProtInc F diacylglycerol kinase activity
GO:0007596 TAS:Reactome P blood coagulation
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0048666 IEA:Ensembl P neuron development
GO:0030168 TAS:Reactome P platelet activation
GO:0007205 IEA:InterPro P protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007165 TAS:ProtInc P signal transduction

KEGG Pathway Links

KEGG Pathway ID Description
hsa00561 Glycerolipid metabolism
hsa00564 Glycerophospholipid metabolism
hsa01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_19184 GPCR downstream signaling

Domain Information

InterPro Annotations

Accession Description
IPR016064 ATP-NAD kinase-like domain
IPR029477 Diacylglycerol kinase type I, N-terminal
IPR000756 Diacylglycerol kinase, accessory domain
IPR001206 Diacylglycerol kinase, catalytic domain
IPR018247 EF-Hand 1, calcium-binding site
IPR002048 EF-hand domain
IPR011992 EF-hand domain pair
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

UniProt Annotations

Entry Information

Gene Name
diacylglycerol kinase, gamma 90kDa
Protein Entry
DGKG_HUMAN
UniProt ID
P49619
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Long; IsoId=P49619-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=P49619-2; Sequence=VSP_001267; Note=May be inactive.; Name=3; IsoId=P49619-3; Sequence=VSP_039922;
Catalytic Activity ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2- diacyl-sn-glycerol 3-phosphate.
Enzyme Regulation Requires phosphatidylserine for maximal activity.
Function Reverses the normal flow of glycerolipid biosynthesis by phosphorylating diacylglycerol back to phosphatidic acid.
Similarity Belongs to the eukaryotic diacylglycerol kinase family.
Similarity Contains 1 DAGKc domain. {ECO
Similarity Contains 2 EF-hand domains. {ECO
Similarity Contains 2 phorbol-ester/DAG-type zinc fingers.
Subcellular Location Cytoplasm. Membrane. Note=Can be loosely bound to the membranes.
Tissue Specificity Predominantly expressed in retina and in a much lesser extent in the brain. Other tissues contain extremely low levels of DGK-gamma.

Identical and Related Proteins

Unique RefSeq proteins for LMP001921 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
124256476 RefSeq NP_001337 791 diacylglycerol kinase gamma isoform 1
124256474 RefSeq NP_001074213 766 diacylglycerol kinase gamma isoform 2
124256474 RefSeq NP_001074214 766 diacylglycerol kinase gamma isoform 3

Identical Sequences to LMP001921 proteins

Reference Database Accession Length Protein Name
GI:124256474 GenBank AAH89411.1 766 Diacylglycerol kinase, gamma 90kDa [Homo sapiens]
GI:124256474 GenBank AAH89411.1 766 Diacylglycerol kinase, gamma 90kDa [Homo sapiens]
GI:124256476 SwissProt P49619.3 791 RecName: Full=Diacylglycerol kinase gamma; Short=DAG kinase gamma; AltName: Full=Diglyceride kinase gamma; Short=DGK-gamma [Homo sapiens]

Related Sequences to LMP001921 proteins

Reference Database Accession Length Protein Name
GI:124256474 DBBJ BAA05132.1 791 diacylglycerol kinase gamma [Homo sapiens]
GI:124256476 DBBJ BAA05132.1 791 diacylglycerol kinase gamma [Homo sapiens]
GI:124256474 DBBJ BAA05132.1 791 diacylglycerol kinase gamma [Homo sapiens]
GI:124256476 DBBJ BAG36871.1 791 unnamed protein product [Homo sapiens]
GI:124256474 DBBJ BAG36871.1 791 unnamed protein product [Homo sapiens]
GI:124256474 DBBJ BAG36871.1 791 unnamed protein product [Homo sapiens]
GI:124256476 GenBank AAC04686.1 791 diacylglycerol kinase 3 [Homo sapiens]
GI:124256476 GenBank AAQ02566.1 792 diacylglycerol kinase, gamma 90kDa, partial [synthetic construct]
GI:124256476 GenBank EAW78202.1 791 hCG2021087, isoform CRA_d [Homo sapiens]
GI:124256474 GenBank EAW78202.1 791 hCG2021087, isoform CRA_d [Homo sapiens]
GI:124256474 GenBank EAW78202.1 791 hCG2021087, isoform CRA_d [Homo sapiens]
GI:124256474 RefSeq NP_001337.2 791 diacylglycerol kinase gamma isoform 1 [Homo sapiens]
GI:124256474 RefSeq NP_001337.2 791 diacylglycerol kinase gamma isoform 1 [Homo sapiens]
GI:124256476 RefSeq XP_003806668.1 791 PREDICTED: diacylglycerol kinase gamma isoform X1 [Pan paniscus]
GI:124256474 RefSeq XP_004038210.1 766 PREDICTED: diacylglycerol kinase gamma isoform 4 [Gorilla gorilla gorilla]
GI:124256474 RefSeq XP_004038210.1 766 PREDICTED: diacylglycerol kinase gamma isoform 4 [Gorilla gorilla gorilla]
GI:124256474 SwissProt P49619.3 791 RecName: Full=Diacylglycerol kinase gamma; Short=DAG kinase gamma; AltName: Full=Diglyceride kinase gamma; Short=DGK-gamma [Homo sapiens]
GI:124256474 SwissProt P49619.3 791 RecName: Full=Diacylglycerol kinase gamma; Short=DAG kinase gamma; AltName: Full=Diglyceride kinase gamma; Short=DGK-gamma [Homo sapiens]