Gene/Proteome Database (LMPD)
LMPD ID
LMP001937
Gene ID
Species
Homo sapiens (Human)
Gene Name
cholecystokinin B receptor
Gene Symbol
Synonyms
CCK-B; CCK2R; GASR
Alternate Names
gastrin/cholecystokinin type B receptor; CCK-BR; CCK2-R; CCK2 receptor; CCK-B receptor; gastrin receptor; cholecystokinin-2 receptor
Chromosome
11
Map Location
11p15.4
Summary
This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| gastrin/cholecystokinin type B receptor | |
|---|---|
| Refseq ID | NP_795344 |
| Protein GI | 28875799 |
| UniProt ID | P32239 |
| mRNA ID | NM_176875 |
| Length | 447 |
| RefSeq Status | REVIEWED |
| MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRALPDEDPPTPSIASLSRLSYTTISTLGPG | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005887 | IC:UniProtKB | C | integral component of plasma membrane |
| GO:0005886 | TAS:Reactome | C | plasma membrane |
| GO:0046935 | TAS:ProtInc | F | 1-phosphatidylinositol-3-kinase regulator activity |
| GO:0004951 | TAS:ProtInc | F | cholecystokinin receptor activity |
| GO:0015054 | IDA:UniProtKB | F | gastrin receptor activity |
| GO:0004435 | TAS:ProtInc | F | phosphatidylinositol phospholipase C activity |
| GO:0031741 | IDA:NTNU_SB | F | type B gastrin/cholecystokinin receptor binding |
| GO:0008283 | TAS:ProtInc | P | cell proliferation |
| GO:0007166 | NAS:UniProtKB | P | cell surface receptor signaling pathway |
| GO:0038188 | TAS:GOC | P | cholecystokinin signaling pathway |
| GO:0007586 | TAS:ProtInc | P | digestion |
| GO:0048565 | IEA:Ensembl | P | digestive tract development |
| GO:0007631 | TAS:ProtInc | P | feeding behavior |
| GO:0001696 | IEA:Ensembl | P | gastric acid secretion |
| GO:0048732 | IEA:Ensembl | P | gland development |
| GO:0008152 | TAS:GOC | P | metabolic process |
| GO:0007200 | TAS:ProtInc | P | phospholipase C-activating G-protein coupled receptor signaling pathway |
| GO:0008284 | IDA:UniProtKB | P | positive regulation of cell proliferation |
| GO:0007204 | IDA:UniProtKB | P | positive regulation of cytosolic calcium ion concentration |
| GO:0043551 | TAS:GOC | P | regulation of phosphatidylinositol 3-kinase activity |
| GO:0007600 | TAS:ProtInc | P | sensory perception |
KEGG Pathway Links
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P32239-1; Sequence=Displayed; Name=2; Synonyms=CCK-C, CCK-BRi4sv; IsoId=P32239-2; Sequence=VSP_033445; Name=3; Synonyms=DeltaCCK-B; IsoId=P32239-3; Sequence=VSP_033444; |
| Function | Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism. |
| Function | Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
| Interaction | Q06124:PTPN11; NbExp=5; IntAct=EBI-1753137, EBI-297779; |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Isoform 1 is expressed in brain, pancreas, stomach, the colon cancer cell line LoVo and the T-lymphoblastoma Jurkat, but not in heart, placenta, liver, lung, skeletal muscle, kidney or the stomach cancer cell line AGS. Expressed at high levels in the small cell lung cancer cell line NCI-H510, at lower levels in NCI-H345, NCI-H69 and GLC-28 cell lines, not expressed in GLC-19 cell line. Within the stomach, expressed at high levels in the mucosa of the gastric fundus and at low levels in the antrum and duodenum. Isoform 2 is present in pancreatic cancer cells and colorectal cancer cells, but not in normal pancreas or colonic mucosa. Isoform 3 is expressed in brain, pancreas, stomach, the stomach cancer cell line AGS and the colon cancer cell line LoVo. {ECO |
| Web Resource | Name=Wikipedia; Note=Cholecystokinin receptor entry; URL="http://en.wikipedia.org/wiki/Cholecystokinin_receptor"; |
Identical and Related Proteins
Unique RefSeq proteins for LMP001937 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 28875799 | RefSeq | NP_795344 | 447 | gastrin/cholecystokinin type B receptor |
Identical Sequences to LMP001937 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:28875799 | DBBJ | BAI46157.1 | 447 | cholecystokinin B receptor, partial [synthetic construct] |
| GI:28875799 | GenBank | ABM92194.1 | 447 | cholecystokinin B receptor [synthetic construct] |
| GI:28875799 | GenBank | ACS10647.1 | 447 | Sequence 13 from patent US 7541151 |
| GI:28875799 | GenBank | AFO05717.1 | 447 | Sequence 355 from patent US 8216786 |
| GI:28875799 | GenBank | AHE02373.1 | 447 | Sequence 61310 from patent US 8586006 |
| GI:28875799 | GenBank | AIC54127.1 | 447 | CCKBR, partial [synthetic construct] |
Related Sequences to LMP001937 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:28875799 | GenBank | AAP36570.1 | 448 | Homo sapiens cholecystokinin B receptor, partial [synthetic construct] |
| GI:28875799 | GenBank | AAX43859.1 | 448 | cholecystokinin B receptor, partial [synthetic construct] |
| GI:28875799 | GenBank | AAX43860.1 | 448 | cholecystokinin B receptor, partial [synthetic construct] |
| GI:28875799 | GenBank | EAW68735.1 | 447 | cholecystokinin B receptor, isoform CRA_b [Homo sapiens] |
| GI:28875799 | GenBank | ACP57169.1 | 447 | Sequence 1298 from patent US 7482117 |
| GI:28875799 | GenBank | ADS30766.1 | 447 | Sequence 1298 from patent US 7781168 |