Gene/Proteome Database (LMPD)

LMPD ID
LMP001948
Gene ID
19219
Species
Mus musculus (Mouse)
Gene Name
prostaglandin E receptor 4 (subtype EP4)
Gene Symbol
Ptger4
Synonyms
EP4; Ptgerep4
Alternate Names
prostaglandin E2 receptor EP4 subtype; prostanoid EP4 receptor; PGE2 receptor EP4 subtype
Chromosome
15
Map Location
15 A1|15 1.99 cM

Proteins

prostaglandin E2 receptor EP4 subtype isoform 1
Refseq ID NP_001129551
Protein GI 209862967
UniProt ID Q91VE4
mRNA ID NM_001136079
Length 488
RefSeq Status VALIDATED
MSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAIYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAAAVASVACRGHAGASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPNVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDSSAQHCSESRRTSSAMSGHSRSFLARELKEISSTSQTLLYLPDLTESSLGGRNLLPGSHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVDEVSGSHREEPASKGNSLQVTFPSETLKLSEKCI
prostaglandin E2 receptor EP4 subtype isoform 2
Refseq ID NP_032991
Protein GI 6679531
UniProt ID P32240
mRNA ID NM_008965
Length 513
RefSeq Status VALIDATED
MAEVGGTIPRSNRELQRCVLLTTTIMSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAIYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAAAVASVACRGHAGASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPNVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDSSAQHCSESRRTSSAMSGHSRSFLARELKEISSTSQTLLYLPDLTESSLGGRNLLPGSHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVDEVSGSHREEPASKGNSLQVTFPSETLKLSEKCI

Gene Information

Entrez Gene ID
19219
Gene Name
prostaglandin E receptor 4 (subtype EP4)
Gene Symbol
Ptger4
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0004957 ISS:UniProtKB F prostaglandin E receptor activity
GO:0070371 ISS:UniProtKB P ERK1 and ERK2 cascade
GO:0007254 ISS:UniProtKB P JNK cascade
GO:0042093 IDA:UniProtKB P T-helper cell differentiation
GO:0007189 TAS:MGI P adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007188 ISS:UniProtKB P adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0060348 ISS:UniProtKB P bone development
GO:0071260 IEP:UniProtKB P cellular response to mechanical stimulus
GO:0050710 IMP:UniProtKB P negative regulation of cytokine secretion
GO:2000420 ISS:UniProtKB P negative regulation of eosinophil extravasation
GO:0050728 ISS:UniProtKB P negative regulation of inflammatory response
GO:0033624 ISS:UniProtKB P negative regulation of integrin activation
GO:0050715 IDA:UniProtKB P positive regulation of cytokine secretion
GO:0050729 IDA:UniProtKB P positive regulation of inflammatory response
GO:0030278 IMP:MGI P regulation of ossification
GO:0051492 IDA:UniProtKB P regulation of stress fiber assembly
GO:0032496 IMP:MGI P response to lipopolysaccharide

KEGG Pathway Links

KEGG Pathway ID Description
mmu04750 Inflammatory mediator regulation of TRP channels

Domain Information

InterPro Annotations

Accession Description
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
IPR001244 Prostaglandin DP receptor
IPR001758 Prostanoid EP4 receptor
IPR008365 Prostanoid receptor

UniProt Annotations

Entry Information

Gene Name
prostaglandin E receptor 4 (subtype EP4)
Protein Entry
Q91VE4_MOUSE
UniProt ID
Q91VE4
Species
Mouse

Comments

Comment Type Description
Caution Was originally designated as the EP2 subtype. {ECO:0000305}.
Function Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.
Ptm Phosphorylation mediates agonist-mediated desensitization by promoting cytoplasmic retention. {ECO:0000250}.
Similarity Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Subunit Interacts with FEM1A. {ECO:0000250}.
Tissue Specificity Abundant expression in ileum, thymus and mastocytoma P-815 cells. Also observed in lung, spleen, heart and uterus.

Identical and Related Proteins

Unique RefSeq proteins for LMP001948 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
209862967 RefSeq NP_001129551 488 prostaglandin E2 receptor EP4 subtype isoform 1
6679531 RefSeq NP_032991 513 prostaglandin E2 receptor EP4 subtype isoform 2

Identical Sequences to LMP001948 proteins

Reference Database Accession Length Protein Name
GI:6679531 DBBJ BAA02714.1 513 prostaglandin E receptor EP2 subtype [Mus musculus]
GI:6679531 GenBank AAB43125.1 513 Sequence 6 from patent US 5576192
GI:6679531 GenBank AAE08200.1 513 Sequence 6 from patent US 5804415
GI:209862967 GenBank AAH09023.1 488 Ptger4 protein [Mus musculus]
GI:209862967 GenBank AAH11193.1 488 Ptger4 protein [Mus musculus]
GI:6679531 GenBank EDL03376.1 513 prostaglandin E receptor 4 (subtype EP4), isoform CRA_a [Mus musculus]
GI:209862967 GenBank EDL03377.1 488 prostaglandin E receptor 4 (subtype EP4), isoform CRA_b [Mus musculus]
GI:6679531 SwissProt P32240.1 513 RecName: Full=Prostaglandin E2 receptor EP4 subtype; Short=PGE receptor EP4 subtype; Short=PGE2 receptor EP4 subtype; AltName: Full=Prostanoid EP4 receptor [Mus musculus]

Related Sequences to LMP001948 proteins

Reference Database Accession Length Protein Name
GI:209862967 DBBJ BAA02714.1 513 prostaglandin E receptor EP2 subtype [Mus musculus]
GI:6679531 DBBJ BAE26204.1 513 unnamed protein product [Mus musculus]
GI:209862967 GenBank AAB43125.1 513 Sequence 6 from patent US 5576192
GI:209862967 GenBank AAE08200.1 513 Sequence 6 from patent US 5804415
GI:6679531 GenBank AAH09023.1 488 Ptger4 protein [Mus musculus]
GI:6679531 GenBank AAH11193.1 488 Ptger4 protein [Mus musculus]
GI:209862967 GenBank EDL03376.1 513 prostaglandin E receptor 4 (subtype EP4), isoform CRA_a [Mus musculus]
GI:6679531 GenBank EDL03377.1 488 prostaglandin E receptor 4 (subtype EP4), isoform CRA_b [Mus musculus]
GI:6679531 GenBank EDL75720.1 512 prostaglandin E receptor 4 (subtype EP4), isoform CRA_a [Rattus norvegicus]
GI:209862967 RefSeq NP_032991.1 513 prostaglandin E2 receptor EP4 subtype isoform 2 [Mus musculus]
GI:6679531 RefSeq NP_001129551.1 488 prostaglandin E2 receptor EP4 subtype isoform 1 [Mus musculus]
GI:209862967 SwissProt P32240.1 513 RecName: Full=Prostaglandin E2 receptor EP4 subtype; Short=PGE receptor EP4 subtype; Short=PGE2 receptor EP4 subtype; AltName: Full=Prostanoid EP4 receptor [Mus musculus]