Gene/Proteome Database (LMPD)

LMPD ID
LMP001950
Gene ID
3157
Species
Homo sapiens (Human)
Gene Name
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
Gene Symbol
HMGCS1
Synonyms
HMGCS
Alternate Names
hydroxymethylglutaryl-CoA synthase, cytoplasmic; 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase; 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)
Chromosome
5
Map Location
5p14-p13
EC Number
2.3.3.10

Proteins

hydroxymethylglutaryl-CoA synthase, cytoplasmic
Refseq ID NP_001091742
Protein GI 148298677
UniProt ID Q01581
mRNA ID NM_001098272
Length 520
RefSeq Status VALIDATED
MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCTDREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDIEGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALLIGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKIHAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAPDVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEGVGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
hydroxymethylglutaryl-CoA synthase, cytoplasmic
Refseq ID NP_002121
Protein GI 148298764
UniProt ID Q01581
mRNA ID NM_002130
Length 520
RefSeq Status VALIDATED
Protein sequence is identical to GI:148298677 (mRNA isoform)

Gene Information

Entrez Gene ID
3157
Gene Name
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
Gene Symbol
HMGCS1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:HPA C cytoplasm
GO:0005829 TAS:Reactome C cytosol
GO:0005634 IDA:HPA C nucleus
GO:0005886 IDA:HPA C plasma membrane
GO:0008144 IEA:Ensembl F drug binding
GO:0004421 TAS:ProtInc F hydroxymethylglutaryl-CoA synthase activity
GO:0016853 IEA:Ensembl F isomerase activity
GO:0043177 IEA:Ensembl F organic acid binding
GO:0007420 IEA:Ensembl P brain development
GO:0044255 TAS:Reactome P cellular lipid metabolic process
GO:0071397 IEA:Ensembl P cellular response to cholesterol
GO:0071372 IEA:Ensembl P cellular response to follicle-stimulating hormone stimulus
GO:0006695 TAS:Reactome P cholesterol biosynthetic process
GO:0008299 IEA:InterPro P isoprenoid biosynthetic process
GO:0006629 NAS:ProtInc P lipid metabolic process
GO:0001889 IEA:Ensembl P liver development
GO:0008584 IEA:Ensembl P male gonad development
GO:0001101 IEA:Ensembl P response to acid chemical
GO:0042493 IEA:Ensembl P response to drug
GO:0055094 IEA:Ensembl P response to lipoprotein particle
GO:0009645 IEA:Ensembl P response to low light intensity stimulus
GO:0014074 IEA:Ensembl P response to purine-containing compound
GO:0046690 IEA:Ensembl P response to tellurium ion
GO:0033197 IEA:Ensembl P response to vitamin E
GO:0044281 TAS:Reactome P small molecule metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00900 Terpenoid backbone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR010122 Hydroxymethylglutaryl-CoA synthase, eukaryotic
IPR013746 Hydroxymethylglutaryl-coenzyme A synthase C-terminal domain
IPR013528 Hydroxymethylglutaryl-coenzyme A synthase, N-terminal
IPR000590 Hydroxymethylglutaryl-coenzyme A synthase, active site
IPR016039 Thiolase-like
IPR016038 Thiolase-like, subgroup

UniProt Annotations

Entry Information

Gene Name
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
Protein Entry
HMCS1_HUMAN
UniProt ID
Q01581
Species
Human

Comments

Comment Type Description
Catalytic Activity Acetyl-CoA + H(2)O + acetoacetyl-CoA = (S)-3- hydroxy-3-methylglutaryl-CoA + CoA. {ECO
Function This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
Pathway Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA
Sequence Caution Sequence=AAH00297.2; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the HMG-CoA synthase family.
Subcellular Location Cytoplasm.

Identical and Related Proteins

Unique RefSeq proteins for LMP001950 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
148298677 RefSeq NP_001091742 520 hydroxymethylglutaryl-CoA synthase, cytoplasmic

Identical Sequences to LMP001950 proteins

Reference Database Accession Length Protein Name
GI:148298677 DBBJ BAG37965.1 520 unnamed protein product [Homo sapiens]
GI:148298677 DBBJ BAI47241.1 520 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1, partial [synthetic construct]
GI:148298677 GenBank AAX41731.1 520 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 [synthetic construct]
GI:148298677 GenBank EAW56054.1 520 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble), isoform CRA_a [Homo sapiens]
GI:148298677 GenBank EAW56056.1 520 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble), isoform CRA_a [Homo sapiens]
GI:148298677 RefSeq NP_002121.4 520 hydroxymethylglutaryl-CoA synthase, cytoplasmic [Homo sapiens]

Related Sequences to LMP001950 proteins

Reference Database Accession Length Protein Name
GI:148298677 GenBank AAH00297.2 555 HMGCS1 protein, partial [Homo sapiens]
GI:148298677 GenBank AAH83514.1 520 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) [Homo sapiens]
GI:148298677 GenBank AHD69503.1 520 Sequence 517 from patent US 8586006
GI:148298677 RefSeq XP_517780.3 520 PREDICTED: hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1 [Pan troglodytes]
GI:148298677 RefSeq XP_008961598.1 520 PREDICTED: hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1 [Pan paniscus]
GI:148298677 RefSeq XP_009447491.1 520 PREDICTED: hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1 [Pan troglodytes]