Gene/Proteome Database (LMPD)

LMPD ID
LMP001956
Gene ID
Species
Homo sapiens (Human)
Gene Name
pleckstrin homology domain containing, family A member 5
Gene Symbol
Synonyms
PEPP-2; PEPP2
Alternate Names
pleckstrin homology domain-containing family A member 5; PH domain-containing family A member 5; phosphoinositol 3-phosphate-binding protein-2
Chromosome
12
Map Location
12p12

Proteins

pleckstrin homology domain-containing family A member 5 isoform 1
Refseq ID NP_061885
Protein GI 19923493
UniProt ID Q9HAU0
mRNA ID NM_019012
Length 1116
RefSeq Status VALIDATED
MAADLNLEWISLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLPTGWEEAYTFEGARYYINHNERKVTCKHPVTGQPSQDNCIFVVNEQTVATMTSEEKKERPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSENAPTKETNNIPNHRVLIKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSEYESGSACPAQTVHYRPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQRTNSMQQLEQWIKIQKGRGHEEETRGVISYQTLPRNMPSHRAQIMARYPEGYRTLPRNSKTRPESICSVTPSTHDKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPKTMVNISDQTMHSIPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVPDRRSVPAGLTLQSVSPQSLQGKTLSQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQALLSASQEIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRNQMQEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGTTEIGMIGSKPFSTVKYKNEGPDYRLYKSEPELTTVAEVDESNGEEKSEPVSEIETSVVKGSHFPVGVVPPRAKSPTPESSTIASYVTLRKTKKMMDLRTERPRSAVEQLCLAESTRPRMTVEEQMERIRRHQQACLREKKKGLNVIGASDQSPLQSPSNLRDNPFRTTQTRRRDDKELDTAIRENDVKPDHETPATEIVQLKETEPQNVDFSKELKKTENISYEMLFEPEPNGVNSVEMMDKERNKDKMPEDVTFSPQDETQTANHKPEEHPEENTKNSVDEQEETVISYESTPEVSRGNQTMAVKSLSPSPESSASPVPSTQPQLTEGSHFMCV
pleckstrin homology domain-containing family A member 5 isoform 2
Refseq ID NP_001137293
Protein GI 307219192
UniProt ID Q9HAU0
mRNA ID NM_001143821
Length 1174
RefSeq Status VALIDATED
MAADLNLEWISLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLPTGWEEAYTFEGARYYINHNERKVTCKHPVTGQPSQDNCIFVVNEQTVATMTSEEKKERPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSENAPTKETNNIPNHRVLIKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSEYESGSACPAQTVHYRPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQRTNSMQQLEQWIKIQKGRGHEEETRGVISYQTLPRNMPSHRAQIMARYPEGYRTLPRNSKTRPESICSVTPSTHDKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPKTMVNISDQTMHSIPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVPDRRSVPAGLTLQSVSPQSLQGKTPEELTLLLIKLRRQQAELSSIREHTLAQLMQLKLEAHSPKNEILSHHLQRNTIYLDHQLSQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQALLSASQEIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRNQMQEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGTTEIGMIGSKPFSTVKYKNEGPDYRLYKSEPELTTVAEVDESNGEEKSEPVSEIETSVVKGSHFPVGVVPPRAKSPTPESSTIASYVTLRKTKKMMDLRTERPRSAVEQLCLAESTRPRMTVEEQMERIRRHQQACLREKKKGLNVIGASDQSPLQSPSNLRDNPFRTTQTRRRDDKELDTAIRENDVKPDHETPATEIVQLKETEPQNVDFSKELKKTENISYEMLFEPEPNGVNSVEMMDKERNKDKMPEDVTFSPQDETQTANHKPEEHPEENTKNSVDEQEETVISYESTPEVSRGNQTMAVKSLSPSPESSASPVPSTQPQLTEGSHFMCV
pleckstrin homology domain-containing family A member 5 isoform 3
Refseq ID NP_001177789
Protein GI 307219194
UniProt ID Q9HAU0
mRNA ID NM_001190860
Length 76
RefSeq Status VALIDATED
MAADLNLEWISLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLPTGWEEAYTFEGARYYIN
pleckstrin homology domain-containing family A member 5 isoform 4
Refseq ID NP_001243399
Protein GI 374349211
UniProt ID Q9HAU0
mRNA ID NM_001256470
Length 1282
RefSeq Status VALIDATED
MAADLNLEWISLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLPTGWEEAYTFEGARYYINHNERKVTCKHPVTGQPSQDNCIFVVNEQTVATMTSEEKKERPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRITFNFRVDKITSENAPTKETNNIPNHRVLIKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSEYESGSACPAQTVHYRPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQRTNSMQQLEQWIKIQKGRGHEEETRGVISYQTLPRNMPSHRAQIMARYPEGYRTLPRNSKTRPESICSVTPSTHDKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPKTMVNISDQTMHSIPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVPDRRSVPAGLTLQSVSPQSLQGKTPEELTLLLIKLRRQQAELSSIREHTLAQLMQLKLEAHSPKNEILSHHLQRNTIYLDHQMKENEPIITMVHTMIENSALRPQLYQQFLRQKSKISLYCLSQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQALLSASQEIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRNQMQEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGTTEIGMIGSKPFSTVKYKNEEEEVVPPRPPLPRSYDFTEQPPIIPPLPSDSSSLLCYSRGPVHLPEEKKMYQVQGYPRNGSHCGPDYRLYKSEPELTTVAEVDESNGEEKSEPVSEIETSVVKGSHFPVGVVPPRAKSPTPESSTIASYVTLRKTKKMMDLRTERPRSAVEQLCLAESTRPRMTVEEQMERIRRHQQACLREKKKGLNVIGASDQSPLQSPSNLRDNPFRTTQTRRRDDKELDTAIRENDVKPDHETPATEIVQLKETEPQNVDFSKELKKTENISYEMLFEPEPNGVNSVEMMDKERNKDKMPEDVTFSPQDETQTANHKPEEHPEENTKNSVDEQEETVISYESTPEVSRGNQTMAVKSLSPSPESSASPVPSTQPQLTEGSHFMCV
pleckstrin homology domain-containing family A member 5 isoform 5
Refseq ID NP_001243716
Protein GI 374349211
UniProt ID Q9HAU0
mRNA ID NM_001256787
Length 1282
RefSeq Status VALIDATED
MAADLNLEWISLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLPTGWEEAYTFEGARYYINHNERKVTCKHPVTGQPSQDNCIFVVNEQTVATMTSEEKKERPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRITFNFRVDKITSENAPTKETNNIPNHRVLIKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSEYESGSACPAQTVHYRPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQRTNSMQQLEQWIKIQKGRGHEEETRGVISYQTLPRNMPSHRAQIMARYPEGYRTLPRNSKTRPESICSVTPSTHDKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPKTMVNISDQTMHSIPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVPDRRSVPAGLTLQSVSPQSLQGKTPEELTLLLIKLRRQQAELSSIREHTLAQLMQLKLEAHSPKNEILSHHLQRNTIYLDHQMKENEPIITMVHTMIENSALRPQLYQQFLRQKSKISLYCLSQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQALLSASQEIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRNQMQEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGTTEIGMIGSKPFSTVKYKNEEEEVVPPRPPLPRSYDFTEQPPIIPPLPSDSSSLLCYSRGPVHLPEEKKMYQVQGYPRNGSHCGPDYRLYKSEPELTTVAEVDESNGEEKSEPVSEIETSVVKGSHFPVGVVPPRAKSPTPESSTIASYVTLRKTKKMMDLRTERPRSAVEQLCLAESTRPRMTVEEQMERIRRHQQACLREKKKGLNVIGASDQSPLQSPSNLRDNPFRTTQTRRRDDKELDTAIRENDVKPDHETPATEIVQLKETEPQNVDFSKELKKTENISYEMLFEPEPNGVNSVEMMDKERNKDKMPEDVTFSPQDETQTANHKPEEHPEENTKNSVDEQEETVISYESTPEVSRGNQTMAVKSLSPSPESSASPVPSTQPQLTEGSHFMCV

Gene Information

Entrez Gene ID
Gene Name
pleckstrin homology domain containing, family A member 5
Gene Symbol
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IEA:Ensembl C cytosol
GO:0016020 IDA:UniProtKB C membrane
GO:0005545 NAS:UniProtKB F 1-phosphatidylinositol binding
GO:0080025 IEA:Ensembl F phosphatidylinositol-3,5-bisphosphate binding
GO:0032266 IEA:Ensembl F phosphatidylinositol-3-phosphate binding
GO:0070273 IEA:Ensembl F phosphatidylinositol-4-phosphate binding
GO:0010314 IEA:Ensembl F phosphatidylinositol-5-phosphate binding
GO:0061458 IEA:Ensembl P reproductive system development

Domain Information

InterPro Annotations

Accession Description
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain
IPR001202 WW domain

UniProt Annotations

Entry Information

Gene Name
pleckstrin homology domain containing, family A member 5
Protein Entry
PKHA5_HUMAN
UniProt ID
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=8; Name=1; Synonyms=S; IsoId=Q9HAU0-1; Sequence=Displayed; Name=2; IsoId=Q9HAU0-2; Sequence=VSP_009775; Note=No experimental confirmation available.; Name=3; IsoId=Q9HAU0-3; Sequence=VSP_009776, VSP_014595; Note=No experimental confirmation available.; Name=4; IsoId=Q9HAU0-4; Sequence=VSP_009778; Note=No experimental confirmation available.; Name=5; IsoId=Q9HAU0-5; Sequence=VSP_009777; Note=No experimental confirmation available.; Name=6; Synonyms=L; IsoId=Q9HAU0-6; Sequence=VSP_044678, VSP_009775, VSP_044679, VSP_009778; Note=Specifically expresssed in brain.; Name=7; IsoId=Q9HAU0-7; Sequence=VSP_046861; Note=No experimental confirmation available.; Name=8; IsoId=Q9HAU0-8; Sequence=VSP_047514, VSP_047515, VSP_009778; Note=No experimental confirmation available.;
Domain Specifically interacts with PI3P, PI4P, PI5P, and PI(3,5)P2.
Interaction P54259:ATN1; NbExp=2; IntAct=EBI-945934, EBI-945980; P54253:ATXN1; NbExp=2; IntAct=EBI-945934, EBI-930964; Q9NWB1:RBFOX1; NbExp=2; IntAct=EBI-945934, EBI-945906;
Sequence Caution Sequence=AAH70174.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence= ; Sequence=BAA91742.1; Type=Frameshift; Positions=759; Evidence= ; Sequence=BAB14419.1; Type=Erroneous initiation; Evidence= ; Sequence=BAB21777.2; Type=Erroneous initiation; Evidence= ;
Similarity Contains 1 PH domain. {ECO
Similarity Contains 2 WW domains. {ECO
Subcellular Location Cytoplasm .
Tissue Specificity Highly expressed in heart and kidney.

Identical and Related Proteins

Unique RefSeq proteins for LMP001956 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
19923493 RefSeq NP_061885 1116 pleckstrin homology domain-containing family A member 5 isoform 1
307219192 RefSeq NP_001137293 1174 pleckstrin homology domain-containing family A member 5 isoform 2
307219194 RefSeq NP_001177789 76 pleckstrin homology domain-containing family A member 5 isoform 3
374349211 RefSeq NP_001243399 1282 pleckstrin homology domain-containing family A member 5 isoform 4
374349211 RefSeq NP_001243716 1282 pleckstrin homology domain-containing family A member 5 isoform 5

Identical Sequences to LMP001956 proteins

Reference Database Accession Length Protein Name
GI:307219192 DBBJ BAG10115.1 1174 pleckstrin homology domain-containing protein, family A member 5, partial [synthetic construct]
GI:374349211 DBBJ BAL45489.1 1282 pleckstrin homology domain-containing family A member 5 [Homo sapiens]
GI:374349211 DBBJ BAL45489.1 1282 pleckstrin homology domain-containing family A member 5 [Homo sapiens]
GI:307219194 GenBank AAH44245.1 76 PLEKHA5 protein [Homo sapiens]
GI:307219194 GenBank EAW96393.1 76 pleckstrin homology domain containing, family A member 5, isoform CRA_b [Homo sapiens]
GI:307219192 GenBank EAW96395.1 1174 pleckstrin homology domain containing, family A member 5, isoform CRA_a [Homo sapiens]
GI:19923493 GenBank EAW96397.1 1116 pleckstrin homology domain containing, family A member 5, isoform CRA_e [Homo sapiens]
GI:19923493 GenBank ADA19612.1 1116 Sequence 1436 from patent US 7608413
GI:19923493 GenBank ADA19613.1 1116 Sequence 1437 from patent US 7608413
GI:307219192 GenBank ADA19614.1 1174 Sequence 1438 from patent US 7608413
GI:307219192 GenBank ADA19616.1 1174 Sequence 1440 from patent US 7608413
GI:19923493 GenBank AEN35508.1 1116 Sequence 1436 from patent US 7998689
GI:19923493 GenBank AEN35509.1 1116 Sequence 1437 from patent US 7998689
GI:307219192 GenBank AEN35510.1 1174 Sequence 1438 from patent US 7998689
GI:307219192 GenBank AEN35512.1 1174 Sequence 1440 from patent US 7998689
GI:19923493 GenBank AHD71820.1 1116 Sequence 6514 from patent US 8586006
GI:307219194 RefSeq XP_005570355.1 76 PREDICTED: pleckstrin homology domain-containing family A member 5 isoform X22 [Macaca fascicularis]
GI:307219194 RefSeq XP_007966030.1 76 PREDICTED: pleckstrin homology domain-containing family A member 5 isoform X34 [Chlorocebus sabaeus]
GI:307219194 RefSeq XP_009178596.1 76 PREDICTED: pleckstrin homology domain-containing family A member 5 isoform X26 [Papio anubis]
GI:307219194 RefSeq XP_010353018.1 76 PREDICTED: pleckstrin homology domain-containing family A member 5 isoform X1 [Rhinopithecus roxellana]

Related Sequences to LMP001956 proteins

Reference Database Accession Length Protein Name
GI:307219192 DBBJ BAB21777.2 1175 KIAA1686 protein, partial [Homo sapiens]
GI:307219194 DBBJ BAB21777.2 1175 KIAA1686 protein, partial [Homo sapiens]
GI:307219194 GenBank EAW96397.1 1116 pleckstrin homology domain containing, family A member 5, isoform CRA_e [Homo sapiens]
GI:307219194 GenBank AEN35508.1 1116 Sequence 1436 from patent US 7998689
GI:307219194 GenBank AEN35509.1 1116 Sequence 1437 from patent US 7998689
GI:19923493 GenBank JAA10086.1 1118 pleckstrin homology domain containing, family A member 5 [Pan troglodytes]
GI:19923493 GenBank JAA13146.1 1118 pleckstrin homology domain containing, family A member 5 [Pan troglodytes]
GI:19923493 GenBank JAA31738.1 1118 pleckstrin homology domain containing, family A member 5 [Pan troglodytes]
GI:19923493 GenBank JAA36687.1 1118 pleckstrin homology domain containing, family A member 5 [Pan troglodytes]
GI:307219194 RefSeq NP_061885.2 1116 pleckstrin homology domain-containing family A member 5 isoform 1 [Homo sapiens]
GI:19923493 RefSeq XP_003906131.1 1118 PREDICTED: pleckstrin homology domain-containing family A member 5 isoform X18 [Papio anubis]
GI:374349211 RefSeq XP_003906132.1 1284 PREDICTED: pleckstrin homology domain-containing family A member 5 isoform X2 [Papio anubis]
GI:374349211 RefSeq XP_003906132.1 1284 PREDICTED: pleckstrin homology domain-containing family A member 5 isoform X2 [Papio anubis]
GI:374349211 RefSeq XP_005570334.1 1280 PREDICTED: pleckstrin homology domain-containing family A member 5 isoform X1 [Macaca fascicularis]
GI:374349211 RefSeq XP_005570334.1 1280 PREDICTED: pleckstrin homology domain-containing family A member 5 isoform X1 [Macaca fascicularis]
GI:307219192 RefSeq XP_005570339.1 1178 PREDICTED: pleckstrin homology domain-containing family A member 5 isoform X6 [Macaca fascicularis]
GI:307219192 RefSeq XP_005570342.1 1172 PREDICTED: pleckstrin homology domain-containing family A member 5 isoform X9 [Macaca fascicularis]
GI:307219192 RefSeq XP_005570343.1 1172 PREDICTED: pleckstrin homology domain-containing family A member 5 isoform X10 [Macaca fascicularis]
GI:374349211 RefSeq XP_006719159.1 1276 PREDICTED: pleckstrin homology domain-containing family A member 5 isoform X11 [Homo sapiens]
GI:374349211 RefSeq XP_006719159.1 1276 PREDICTED: pleckstrin homology domain-containing family A member 5 isoform X11 [Homo sapiens]
GI:374349211 RefSeq XP_007965994.1 1284 PREDICTED: pleckstrin homology domain-containing family A member 5 isoform X1 [Chlorocebus sabaeus]
GI:374349211 RefSeq XP_007965994.1 1284 PREDICTED: pleckstrin homology domain-containing family A member 5 isoform X1 [Chlorocebus sabaeus]
GI:374349211 RefSeq XP_007965996.1 1278 PREDICTED: pleckstrin homology domain-containing family A member 5 isoform X2 [Chlorocebus sabaeus]
GI:374349211 RefSeq XP_007965996.1 1278 PREDICTED: pleckstrin homology domain-containing family A member 5 isoform X2 [Chlorocebus sabaeus]
GI:307219192 RefSeq XP_007966003.1 1221 PREDICTED: pleckstrin homology domain-containing family A member 5 isoform X9 [Chlorocebus sabaeus]
GI:307219192 RefSeq XP_007966010.1 1176 PREDICTED: pleckstrin homology domain-containing family A member 5 isoform X15 [Chlorocebus sabaeus]
GI:19923493 RefSeq XP_007966015.1 1118 PREDICTED: pleckstrin homology domain-containing family A member 5 isoform X19 [Chlorocebus sabaeus]
GI:374349211 RefSeq XP_009178571.1 1285 PREDICTED: pleckstrin homology domain-containing family A member 5 isoform X1 [Papio anubis]
GI:374349211 RefSeq XP_009178571.1 1285 PREDICTED: pleckstrin homology domain-containing family A member 5 isoform X1 [Papio anubis]
GI:307219194 SwissProt Q9HAU0.1 1116 RecName: Full=Pleckstrin homology domain-containing family A member 5; Short=PH domain-containing family A member 5; AltName: Full=Phosphoinositol 3-phosphate-binding protein 2; Short=PEPP-2 [Homo sapiens]