Gene/Proteome Database (LMPD)

LMPD ID
LMP001961
Gene ID
230027
Species
Mus musculus (Mouse)
Gene Name
coenzyme Q3 homolog, methyltransferase (yeast)
Gene Symbol
Coq3
Synonyms
4732433J24; C77934
Alternate Names
hexaprenyldihydroxybenzoate methyltransferase, mitochondrial; DHHB-MT; DHHB-MTase; DHHB methyltransferase; Coenzyme Q (ubiquinone); coenzyme Q3 homolog methyltransferase; 2-polyprenyl-6-hydroxyphenol methylase; 2-polyprenyl-6-hydroxyphenyl methylase; 3-demethylubiquinone-9 3-methyltransferase; dihydroxyhexaprenylbenzoate methyltransferase; 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase
Chromosome
4
Map Location
4 A3|4 9.11 cM
EC Number
2.1.1.114

Proteins

hexaprenyldihydroxybenzoate methyltransferase, mitochondrial
Refseq ID NP_766275
Protein GI 27369992
UniProt ID Q8BMS4
mRNA ID NM_172687
Length 370
RefSeq Status PROVISIONAL
MWRGGRLGSRGVRLLETLGFGCPSAVAQPPRLTSRSAYSGTQLTRNLQIKPWELGEHGTMCFRSYRMALSCLSRVKTYRTPWKRLYSTSQTTVDSREVKNFQALAHTWWDEYGKFAPLHSMNDLRVPFIRDNLLKTSASHHPGKPLSGMKILDVGCGGGLLTEPLGRLGASVVGIDPVAENIKIAQHHKSFDPVLDKRIQYKVCSLEEAVDESAECFDAVVASEVVEHVSHLEMFIQCCYQVLKPGGSLFITTVNKTQLSYALGIVFAEQIAGIVPKGTHTWEKFVSPEKLESILEPNGLSVETVAGLVYNPFSGYWHWSENTSLNYAAHAVRSRAQEHQEPAESALKGETGALHANTSGSPSVREEQRT

Gene Information

Entrez Gene ID
230027
Gene Name
coenzyme Q3 homolog, methyltransferase (yeast)
Gene Symbol
Coq3
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IDA:MGI C mitochondrion
GO:0008425 IEA:InterPro F 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
GO:0008689 IEA:UniProtKB-EC F 3-demethylubiquinone-9 3-O-methyltransferase activity
GO:0004395 IEA:UniProtKB-EC F hexaprenyldihydroxybenzoate methyltransferase activity
GO:0006071 IEA:Ensembl P glycerol metabolic process
GO:0006744 IEA:UniProtKB-UniPathway P ubiquinone biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu01100 Metabolic pathways
mmu00130 Ubiquinone and other terpenoid-quinone biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5894069 Ubiquinol biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
IPR010233 Ubiquinone biosynthesis O-methyltransferase

UniProt Annotations

Entry Information

Gene Name
coenzyme Q3 homolog, methyltransferase (yeast)
Protein Entry
COQ3_MOUSE
UniProt ID
Q8BMS4
Species
Mouse

Comments

Comment Type Description
Catalytic Activity S-adenosyl-L-methionine + 3,4-dihydroxy-5-all- trans-polyprenylbenzoate = S-adenosyl-L-homocysteine + 3-methoxy- 4-hydroxy-5-all-trans-polyprenylbenzoate.
Catalytic Activity S-adenosyl-L-methionine + 3- demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n.
Catalytic Activity S-adenosyl-L-methionine + 3-(all-trans- polyprenyl)benzene-1,2-diol = S-adenosyl-L-homocysteine + 2- methoxy-6-(all-trans-polyprenyl)phenol.
Pathway Cofactor biosynthesis; ubiquinone biosynthesis.
Sequence Caution Sequence=BAC29030.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the methyltransferase superfamily. UbiG/COQ3 family. {ECO:0000305}.
Subcellular Location Mitochondrion matrix {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001961 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
27369992 RefSeq NP_766275 370 hexaprenyldihydroxybenzoate methyltransferase, mitochondrial

Identical Sequences to LMP001961 proteins

Reference Database Accession Length Protein Name
GI:27369992 DBBJ BAC26063.1 370 unnamed protein product [Mus musculus]
GI:27369992 DBBJ BAE41830.1 370 unnamed protein product [Mus musculus]
GI:27369992 GenBank EDL05548.1 370 coenzyme Q3 homolog, methyltransferase (yeast) [Mus musculus]
GI:27369992 SwissProt Q8BMS4.1 370 RecName: Full=Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial; AltName: Full=2-polyprenyl-6-hydroxyphenol methylase; AltName: Full=3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase; Short=DHHB methyltransferase; Short=DHHB-MT; Short=DHHB-MTase; AltName: Full=3-demethylubiquinone-9 3-methyltransferase; AltName: Full=Dihydroxyhexaprenylbenzoate methyltransferase; Flags: Precursor [Mus musculus]

Related Sequences to LMP001961 proteins

Reference Database Accession Length Protein Name
GI:27369992 DBBJ BAC29030.1 311 unnamed protein product [Mus musculus]
GI:27369992 DBBJ BAE38796.1 311 unnamed protein product [Mus musculus]
GI:27369992 DBBJ BAE25011.1 311 unnamed protein product [Mus musculus]
GI:27369992 GenBank AAH60960.1 370 Coenzyme Q3 homolog, methyltransferase (yeast) [Mus musculus]
GI:27369992 GenBank AAI26095.1 345 Coq3 protein [Rattus norvegicus]
GI:27369992 RefSeq XP_006537871.1 311 PREDICTED: hexaprenyldihydroxybenzoate methyltransferase, mitochondrial isoform X1 [Mus musculus]