Gene/Proteome Database (LMPD)

LMPD ID
LMP001965
Gene ID
8708
Species
Homo sapiens (Human)
Gene Name
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
Gene Symbol
B3GALT1
Synonyms
beta3Gal-T1
Alternate Names
beta-1,3-galactosyltransferase 1; beta3GalT1; beta-3-galt1; beta-1,3-GalTase 1; UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1
Chromosome
2
Map Location
2q24.3
EC Number
2.4.1.-
Summary
This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene is expressed exclusively in the brain. The encoded protein shows strict donor substrate specificity for UDP-galactose. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for B3GALT1

Proteins

beta-1,3-galactosyltransferase 1
Refseq ID NP_066191
Protein GI 10304987
UniProt ID Q9Y5Z6
mRNA ID NM_020981
Length 326
RefSeq Status REVIEWED
MASKVSCLYVLTVVCWASALWYLSITRPTSSYTGSKPFSHLTVARKNFTFGNIRTRPINPHSFEFLINEPNKCEKNIPFLVILISTTHKEFDARQAIRETWGDENNFKGIKIATLFLLGKNADPVLNQMVEQESQIFHDIIVEDFIDSYHNLTLKTLMGMRWVATFCSKAKYVMKTDSDIFVNMDNLIYKLLKPSTKPRRRYFTGYVINGGPIRDVRSKWYMPRDLYPDSNYPPFCSGTGYIFSADVAELIYKTSLHTRLLHLEDVYVGLCLRKLGIHPFQNSGFNHWKMAYSLCRYRRVITVHQISPEEMHRIWNDMSSKKHLRC

Gene Information

Entrez Gene ID
8708
Gene Name
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
Gene Symbol
B3GALT1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0000139 IEA:Ensembl C Golgi membrane
GO:0016021 NAS:UniProtKB C integral component of membrane
GO:0008499 IDA:UniProtKB F UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity
GO:0009312 IEA:Ensembl P oligosaccharide biosynthetic process
GO:0006486 IDA:UniProtKB P protein glycosylation

KEGG Pathway Links

KEGG Pathway ID Description
hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series
M00070 Glycosphingolipid biosynthesis, lacto-series, LacCer => Lc4Cer
hsa01100 Metabolic pathways

Domain Information

InterPro Annotations

Accession Description
IPR002659 Glycosyl transferase, family 31
IPR029044 Nucleotide-diphospho-sugar transferases

UniProt Annotations

Entry Information

Gene Name
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
Protein Entry
B3GT1_HUMAN
UniProt ID
Q9Y5Z6
Species
Human

Comments

Comment Type Description
Cofactor Name=Mn(2+); Xref=ChEBI
Function Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N- acetylglucosamine (beta-GlcNAc) residue. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N- acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues.
Pathway Protein modification; protein glycosylation.
Similarity Belongs to the glycosyltransferase 31 family.
Subcellular Location Golgi apparatus membrane ; Single-pass type II membrane protein .
Tissue Specificity Detected in brain and colon mucosa and to a lesser extent in colon adenocarcinoma cells.
Web Resource Name=Functional Glycomics Gateway - GTase; Note=Beta-1,3-galactosyltransferase 1; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_429";
Web Resource Name=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B3GALT1";

Identical and Related Proteins

Unique RefSeq proteins for LMP001965 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
10304987 RefSeq NP_066191 326 beta-1,3-galactosyltransferase 1

Identical Sequences to LMP001965 proteins

Reference Database Accession Length Protein Name
GI:10304987 RefSeq XP_008976300.1 326 PREDICTED: beta-1,3-galactosyltransferase 1 [Pan paniscus]
GI:10304987 RefSeq XP_008976301.1 326 PREDICTED: beta-1,3-galactosyltransferase 1 [Pan paniscus]
GI:10304987 RefSeq XP_009441753.1 326 PREDICTED: beta-1,3-galactosyltransferase 1 isoform X1 [Pan troglodytes]
GI:10304987 RefSeq XP_009441754.1 326 PREDICTED: beta-1,3-galactosyltransferase 1 isoform X1 [Pan troglodytes]
GI:10304987 RefSeq XP_009441755.1 326 PREDICTED: beta-1,3-galactosyltransferase 1 isoform X1 [Pan troglodytes]
GI:10304987 RefSeq XP_009441756.1 326 PREDICTED: beta-1,3-galactosyltransferase 1 isoform X1 [Pan troglodytes]

Related Sequences to LMP001965 proteins

Reference Database Accession Length Protein Name
GI:10304987 RefSeq XP_004267308.1 326 PREDICTED: beta-1,3-galactosyltransferase 1 [Orcinus orca]
GI:10304987 RefSeq XP_006732944.1 348 PREDICTED: beta-1,3-galactosyltransferase 1 [Leptonychotes weddellii]
GI:10304987 RefSeq XP_006921221.1 326 PREDICTED: beta-1,3-galactosyltransferase 1 [Pteropus alecto]
GI:10304987 RefSeq XP_007112826.1 326 PREDICTED: beta-1,3-galactosyltransferase 1-like [Physeter catodon]
GI:10304987 RefSeq XP_007183282.1 326 PREDICTED: beta-1,3-galactosyltransferase 1 [Balaenoptera acutorostrata scammoni]
GI:10304987 RefSeq XP_008256923.1 326 PREDICTED: beta-1,3-galactosyltransferase 1 [Oryctolagus cuniculus]