Gene/Proteome Database (LMPD)

LMPD ID
LMP001966
Gene ID
124872
Species
Homo sapiens (Human)
Gene Name
beta-1,4-N-acetyl-galactosaminyl transferase 2
Gene Symbol
B4GALNT2
Synonyms
B4GALT; GALGT2
Alternate Names
beta-1,4 N-acetylgalactosaminyltransferase 2; sda beta-1,4-GalNAc transferase; sd(a) beta-1,4-GalNAc transferase; beta-4-N-acetylgalactosaminyltransferase; UDP-GalNAc:Neu5Aca2-3Galb-R b1,4-N-acetylgalactosaminyltransferase; beta 1,4 N-acetylgalactosaminyltransferase/betal,4 GalNAcT/Sda-GalNAcT; UDP-GalNAc:Neu5Acalpha2-3Galbeta-R beta1,4-N-acetylgalactosaminyltransferase
Chromosome
17
Map Location
17q21.32
EC Number
2.4.1.-
Summary
B4GALNT2 catalyzes the last step in the biosynthesis of the human Sd(a) antigen through the addition of an N-acetylgalactosamine residue via a beta-1,4 linkage to a subterminal galactose residue substituted with an alpha-2,3-linked sialic acid. B4GALNT2 also catalyzes the last step in the biosynthesis of the Cad antigen (Montiel et al., 2003 [PubMed 12678917]).[supplied by OMIM, Mar 2008]
Orthologs
View orthologs and multiple alignments for B4GALNT2

Proteins

beta-1,4 N-acetylgalactosaminyltransferase 2 isoform a
Refseq ID NP_703147
Protein GI 227497754
UniProt ID Q8NHY0
mRNA ID NM_153446
Length 566
RefSeq Status VALIDATED
MGSAGFSVGKFHVEVASRGRECVSGTPECGNRLGSAGFGALCLELRGADPAWGPFAAHGRSRRQGSRFLWLLKILVIILVLGIVGFMFGSMFLQAVFSSPKPELPSPAPGVQKLKLLPEERLRNLFSYDGIWLFPKNQCKCEANKEQGGYNFQDAYGQSDLPAVKARRQAEFEHFQRREGLPRPLPLLVQPNLPFGYPVHGVEVMPLHTVPIPGLQFEGPDAPVYEVTLTASLGTLNTLADVPDSVVQGRGQKQLIISTSDRKLLKFILQHVTYTSTGYQHQKVDIVSLESRSSVAKFPVTIRHPVIPKLYDPGPERKLRNLVTIATKTFLRPHKLMIMLRSIREYYPDLTVIVADDSQKPLEIKDNHVEYYTMPFGKGWFAGRNLAISQVTTKYVLWVDDDFLFNEETKIEVLVDVLEKTELDVVGGSVLGNVFQFKLLLEQSENGACLHKRMGFFQPLDGFPSCVVTSGVVNFFLAHTERLQRVGFDPRLQRVAHSEFFIDGLGTLLVGSCPEVIIGHQSRSPVVDSELAALEKTYNTYRSNTLTRVQFKLALHYFKNHLQCAA
beta-1,4 N-acetylgalactosaminyltransferase 2 isoform b
Refseq ID NP_001152859
Protein GI 227498224
UniProt ID Q8NHY0
mRNA ID NM_001159387
Length 506
RefSeq Status VALIDATED
MTSGGSRFLWLLKILVIILVLGIVGFMFGSMFLQAVFSSPKPELPSPAPGVQKLKLLPEERLRNLFSYDGIWLFPKNQCKCEANKEQGGYNFQDAYGQSDLPAVKARRQAEFEHFQRREGLPRPLPLLVQPNLPFGYPVHGVEVMPLHTVPIPGLQFEGPDAPVYEVTLTASLGTLNTLADVPDSVVQGRGQKQLIISTSDRKLLKFILQHVTYTSTGYQHQKVDIVSLESRSSVAKFPVTIRHPVIPKLYDPGPERKLRNLVTIATKTFLRPHKLMIMLRSIREYYPDLTVIVADDSQKPLEIKDNHVEYYTMPFGKGWFAGRNLAISQVTTKYVLWVDDDFLFNEETKIEVLVDVLEKTELDVVGGSVLGNVFQFKLLLEQSENGACLHKRMGFFQPLDGFPSCVVTSGVVNFFLAHTERLQRVGFDPRLQRVAHSEFFIDGLGTLLVGSCPEVIIGHQSRSPVVDSELAALEKTYNTYRSNTLTRVQFKLALHYFKNHLQCAA
beta-1,4 N-acetylgalactosaminyltransferase 2 isoform c
Refseq ID NP_001152860
Protein GI 227497758
UniProt ID Q8NHY0
mRNA ID NM_001159388
Length 480
RefSeq Status VALIDATED
MFGSMFLQAVFSSPKPELPSPAPGVQKLKLLPEERLRNLFSYDGIWLFPKNQCKCEANKEQGGYNFQDAYGQSDLPAVKARRQAEFEHFQRREGLPRPLPLLVQPNLPFGYPVHGVEVMPLHTVPIPGLQFEGPDAPVYEVTLTASLGTLNTLADVPDSVVQGRGQKQLIISTSDRKLLKFILQHVTYTSTGYQHQKVDIVSLESRSSVAKFPVTIRHPVIPKLYDPGPERKLRNLVTIATKTFLRPHKLMIMLRSIREYYPDLTVIVADDSQKPLEIKDNHVEYYTMPFGKGWFAGRNLAISQVTTKYVLWVDDDFLFNEETKIEVLVDVLEKTELDVVGGSVLGNVFQFKLLLEQSENGACLHKRMGFFQPLDGFPSCVVTSGVVNFFLAHTERLQRVGFDPRLQRVAHSEFFIDGLGTLLVGSCPEVIIGHQSRSPVVDSELAALEKTYNTYRSNTLTRVQFKLALHYFKNHLQCAA

Gene Information

Entrez Gene ID
124872
Gene Name
beta-1,4-N-acetyl-galactosaminyl transferase 2
Gene Symbol
B4GALNT2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030173 IEA:InterPro C integral component of Golgi membrane
GO:0016021 NAS:UniProtKB C integral component of membrane
GO:0008376 IDA:UniProtKB F acetylgalactosaminyltransferase activity
GO:0030259 IEA:InterPro P lipid glycosylation
GO:0022408 IDA:UniProtKB P negative regulation of cell-cell adhesion
GO:0006486 IEA:UniProtKB-UniPathway P protein glycosylation
GO:0019276 IDA:UniProtKB P UDP-N-acetylgalactosamine metabolic process
GO:0006047 IEA:Ensembl P UDP-N-acetylglucosamine metabolic process

Domain Information

InterPro Annotations

Accession Description
IPR011143 Ganglioside GM2 synthase
IPR001173 Glycosyltransferase 2-like
IPR029044 Nucleotide-diphospho-sugar transferases

UniProt Annotations

Entry Information

Gene Name
beta-1,4-N-acetyl-galactosaminyl transferase 2
Protein Entry
B4GN2_HUMAN
UniProt ID
Q8NHY0
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8NHY0-1; Sequence=Displayed; Name=2; IsoId=Q8NHY0-2; Sequence=VSP_017131; Name=3; IsoId=Q8NHY0-3; Sequence=VSP_045195; Note=No experimental confirmation available.;
Function Involved in the synthesis of the Sd(a) antigen (Sia- alpha2,3-[GalNAc-beta1,4]Gal-beta1,4-GlcNAc), a carbohydrate determinant expressed on erythrocytes, the colonic mucosa and other tissues. Transfers a beta-1,4-linked GalNAc to the galactose residue of an alpha-2,3-sialylated chain.
Pathway Protein modification; protein glycosylation.
Similarity Belongs to the glycosyltransferase 2 family.
Subcellular Location Golgi apparatus membrane ; Single-pass type II membrane protein .
Tissue Specificity Widely expressed. Highly expressed in colon and to a lesser extent in kidney, stomach, ileum and rectum.
Web Resource Name=Functional Glycomics Gateway - GTase; Note=Beta-1,4 N-acetylgalactosaminyltransferase 2; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_482";
Web Resource Name=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B4GALNT2";

Identical and Related Proteins

Unique RefSeq proteins for LMP001966 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
227497754 RefSeq NP_703147 566 beta-1,4 N-acetylgalactosaminyltransferase 2 isoform a
227498224 RefSeq NP_001152859 506 beta-1,4 N-acetylgalactosaminyltransferase 2 isoform b
227497758 RefSeq NP_001152860 480 beta-1,4 N-acetylgalactosaminyltransferase 2 isoform c

Identical Sequences to LMP001966 proteins

Reference Database Accession Length Protein Name
GI:227497758 DBBJ BAG64056.1 480 unnamed protein product [Homo sapiens]
GI:227498224 EMBL CAD57149.1 506 sda beta-1,4-GalNAc transferase, partial [Homo sapiens]
GI:227498224 GenBank AAS37146.1 506 Sequence 2 from patent US 6692947
GI:227497758 GenBank EAW94691.1 480 beta-1,4-N-acetyl-galactosaminyl transferase 2, isoform CRA_b [Homo sapiens]
GI:227497754 SwissProt Q8NHY0.2 566 RecName: Full=Beta-1,4 N-acetylgalactosaminyltransferase 2; AltName: Full=Sd(a) beta-1,4-GalNAc transferase; AltName: Full=UDP-GalNAc:Neu5Aca2-3Galb-R b1,4-N-acetylgalactosaminyltransferase [Homo sapiens]

Related Sequences to LMP001966 proteins

Reference Database Accession Length Protein Name
GI:227497758 EMBL CAD57148.1 566 sda beta-1,4-GalNAc transferase, partial [Homo sapiens]
GI:227497754 EMBL CAD57148.1 566 sda beta-1,4-GalNAc transferase, partial [Homo sapiens]
GI:227498224 EMBL CAD57148.1 566 sda beta-1,4-GalNAc transferase, partial [Homo sapiens]
GI:227497758 EMBL CAD57149.1 506 sda beta-1,4-GalNAc transferase, partial [Homo sapiens]
GI:227497754 GenBank AAM34756.1 566 beta-4-N-acetylgalactosaminyltransferase [Homo sapiens]
GI:227497758 GenBank AAS37146.1 506 Sequence 2 from patent US 6692947
GI:227498224 GenBank AAI13676.1 566 Beta-1,4-N-acetyl-galactosaminyl transferase 2 [Homo sapiens]
GI:227497754 GenBank AAI13676.1 566 Beta-1,4-N-acetyl-galactosaminyl transferase 2 [Homo sapiens]
GI:227498224 GenBank AAI13678.1 566 Beta-1,4-N-acetyl-galactosaminyl transferase 2 [Homo sapiens]
GI:227497754 GenBank AAI13678.1 566 Beta-1,4-N-acetyl-galactosaminyl transferase 2 [Homo sapiens]
GI:227497754 GenBank EAW94690.1 566 beta-1,4-N-acetyl-galactosaminyl transferase 2, isoform CRA_a [Homo sapiens]
GI:227498224 GenBank EAW94690.1 566 beta-1,4-N-acetyl-galactosaminyl transferase 2, isoform CRA_a [Homo sapiens]
GI:227497754 GenBank ADR83075.1 566 beta-1,4-N-acetyl-galactosaminyl transferase 2, partial [synthetic construct]
GI:227497758 RefSeq NP_703147.2 566 beta-1,4 N-acetylgalactosaminyltransferase 2 isoform a [Homo sapiens]
GI:227498224 RefSeq NP_703147.2 566 beta-1,4 N-acetylgalactosaminyltransferase 2 isoform a [Homo sapiens]
GI:227497758 RefSeq NP_001152859.1 506 beta-1,4 N-acetylgalactosaminyltransferase 2 isoform b [Homo sapiens]
GI:227498224 SwissProt Q8NHY0.2 566 RecName: Full=Beta-1,4 N-acetylgalactosaminyltransferase 2; AltName: Full=Sd(a) beta-1,4-GalNAc transferase; AltName: Full=UDP-GalNAc:Neu5Aca2-3Galb-R b1,4-N-acetylgalactosaminyltransferase [Homo sapiens]
GI:227497758 SwissProt Q8NHY0.2 566 RecName: Full=Beta-1,4 N-acetylgalactosaminyltransferase 2; AltName: Full=Sd(a) beta-1,4-GalNAc transferase; AltName: Full=UDP-GalNAc:Neu5Aca2-3Galb-R b1,4-N-acetylgalactosaminyltransferase [Homo sapiens]