Gene/Proteome Database (LMPD)
LMPD ID
LMP001971
Gene ID
Species
Homo sapiens (Human)
Gene Name
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
Gene Symbol
Synonyms
B3GAL-T8; B3GN-T3; B3GNT-3; HP10328; TMEM3; beta3Gn-T3
Alternate Names
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3; beta3GalT8; beta-3-Gx-T8; beta-1,3-Gn-T3; beta-1,3-GalTase 8; core1-beta3GlcNAcT; transmembrane protein 3; putative type II membrane protein; beta-1,3-N-acetylglucosaminyltransferase bGnT-3; UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 8; core 1 extending beta-1,3-N-acetylglucosaminyltransferase; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 8
Chromosome
19
Map Location
19p13.1
EC Number
2.4.1.146
Summary
This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein and contains a signal anchor that is not cleaved. It prefers the substrates of lacto-N-tetraose and lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains and the biosynthesis of the backbone structure of dimeric sialyl Lewis a. It plays dominant roles in L-selectin ligand biosynthesis, lymphocyte homing and lymphocyte trafficking. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 | |
---|---|
Refseq ID | NP_055071 |
Protein GI | 92091604 |
UniProt ID | Q9Y2A9 |
mRNA ID | NM_014256 |
Length | 372 |
RefSeq Status | REVIEWED |
MKYLRHRRPNATLILAIGAFTLLLFSLLVSPPTCKVQEQPPAIPEALAWPTPPTRPAPAPCHANTSMVTHPDFATQPQHVQNFLLYRHCRHFPLLQDVPPSKCAQPVFLLLVIKSSPSNYVRRELLRRTWGRERKVRGLQLRLLFLVGTASNPHEARKVNRLLELEAQTHGDILQWDFHDSFFNLTLKQVLFLQWQETRCANASFVLNGDDDVFAHTDNMVFYLQDHDPGRHLFVGQLIQNVGPIRAFWSKYYVPEVVTQNERYPPYCGGGGFLLSRFTAAALRRAAHVLDIFPIDDVFLGMCLELEGLKPASHSGIRTSGVRAPSQRLSSFDPCFYRDLLLVHRFLPYEMLLMWDALNQPNLTCGNQTQIY |
Gene Information
Entrez Gene ID
Gene Name
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
GO ID | Source | Type | Description |
---|---|---|---|
GO:0000139 | TAS:Reactome | C | Golgi membrane |
GO:0005887 | TAS:ProtInc | C | integral component of plasma membrane |
GO:0047223 | IEA:UniProtKB-EC | F | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity |
GO:0008378 | IEA:InterPro | F | galactosyltransferase activity |
GO:0016266 | TAS:Reactome | P | O-glycan processing |
GO:0005975 | TAS:Reactome | P | carbohydrate metabolic process |
GO:0044267 | TAS:Reactome | P | cellular protein metabolic process |
GO:0030203 | TAS:Reactome | P | glycosaminoglycan metabolic process |
GO:0018146 | TAS:Reactome | P | keratan sulfate biosynthetic process |
GO:0042339 | TAS:Reactome | P | keratan sulfate metabolic process |
GO:0043687 | TAS:Reactome | P | post-translational protein modification |
GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
REACTOME Pathway Links
REACTOME Pathway ID | Description |
---|---|
REACT_121315 | Glycosaminoglycan metabolism |
REACT_121120 | Keratan sulfate biosynthesis |
REACT_121288 | Keratan sulfate/keratin metabolism |
REACT_200727 | O-linked glycosylation |
Domain Information
InterPro Annotations
Accession | Description |
---|---|
IPR002659 | Glycosyl transferase, family 31 |
UniProt Annotations
Entry Information
Gene Name
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
Protein Entry
B3GN3_HUMAN
UniProt ID
Species
Human
Comments
Comment Type | Description |
---|---|
Catalytic Activity | UDP-N-acetyl-D-glucosamine + beta-D- galactosyl-(1->3)-(N-acetyl-D-glucosaminyl-(1->6))-N-acetyl-D- galactosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta- D-galactosyl-(1->3)-(N-acetyl-D-glucosaminyl-(1->6))-N-acetyl-D- galactosaminyl-R. |
Function | Has a beta-1,3-N-acetylglucosaminyltransferase activity for type 2 oligosaccharides. |
Pathway | Protein modification; protein glycosylation. |
Sequence Caution | Sequence=CAC82374.1; Type=Frameshift; Positions=194, 196, 202, 204, 209, 215; Evidence= ; |
Similarity | Belongs to the glycosyltransferase 31 family. |
Subcellular Location | Golgi apparatus membrane ; Single-pass type II membrane protein . |
Tissue Specificity | Expressed in colon, jejunum, stomach, esophagus, placenta and trachea. |
Web Resource | Name=Functional Glycomics Gateway - GTase; Note=UDP- GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_536"; |
Web Resource | Name=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B3GNT3"; |
Identical and Related Proteins
Unique RefSeq proteins for LMP001971 (as displayed in Record Overview)
Protein GI | Database | Accession | Length | Protein Name |
---|---|---|---|---|
92091604 | RefSeq | NP_055071 | 372 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 |
Identical Sequences to LMP001971 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:92091604 | DBBJ | BAB21531.1 | 372 | beta-1,3-N-acetylglucosaminyltransferase bGnT-3 [Homo sapiens] |
GI:92091604 | DBBJ | BAG36971.1 | 372 | unnamed protein product [Homo sapiens] |
GI:92091604 | GenBank | ABE22280.1 | 372 | Sequence 3 from patent US 7005279 |
GI:92091604 | GenBank | ADT47434.1 | 372 | Sequence 1095 from patent US 7842466 |
GI:92091604 | GenBank | AEK14088.1 | 372 | Sequence 3 from patent US 7972815 |
GI:92091604 | SwissProt | Q9Y2A9.2 | 372 | RecName: Full=UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3; Short=BGnT-3; Short=Beta-1,3-Gn-T3; Short=Beta-1,3-N-acetylglucosaminyltransferase 3; Short=Beta3Gn-T3; AltName: Full=Beta-1,3-galactosyltransferase 8; Short=Beta-1,3-GalTase 8; Short=Beta3Gal-T8; Short=Beta3GalT8; Short=b3Gal-T8; AltName: Full=Beta-3-Gx-T8; AltName: Full=Core 1 extending beta-1,3-N-acetylglucosaminyltransferase; AltName: Full=Core1-beta3GlcNAcT; AltName: Full=Transmembrane protein 3; AltName: Full=UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 8; AltName: Full=UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 8 [Homo sapiens] |
Related Sequences to LMP001971 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:92091604 | EMBL | CAC45044.1 | 372 | beta-1,3-galactosyltransferase [Homo sapiens] |
GI:92091604 | GenBank | AAK00849.1 | 372 | core 1 extending beta-1,3-N-acetylglucosaminyltransferase [Homo sapiens] |
GI:92091604 | GenBank | ACG89668.1 | 372 | Sequence 288 from patent US 7385033 |
GI:92091604 | GenBank | ACG93156.1 | 372 | Sequence 288 from patent US 7388073 |
GI:92091604 | GenBank | ACH02175.1 | 372 | Sequence 288 from patent US 7390886 |
GI:92091604 | GenBank | ACW23822.1 | 372 | Sequence 288 from patent US 7563867 |