Gene/Proteome Database (LMPD)

LMPD ID
LMP001971
Gene ID
10331
Species
Homo sapiens (Human)
Gene Name
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
Gene Symbol
B3GNT3
Synonyms
B3GAL-T8; B3GN-T3; B3GNT-3; HP10328; TMEM3; beta3Gn-T3
Alternate Names
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3; beta3GalT8; beta-3-Gx-T8; beta-1,3-Gn-T3; beta-1,3-GalTase 8; core1-beta3GlcNAcT; transmembrane protein 3; putative type II membrane protein; beta-1,3-N-acetylglucosaminyltransferase bGnT-3; UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 8; core 1 extending beta-1,3-N-acetylglucosaminyltransferase; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 8
Chromosome
19
Map Location
19p13.1
EC Number
2.4.1.146
Summary
This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein and contains a signal anchor that is not cleaved. It prefers the substrates of lacto-N-tetraose and lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains and the biosynthesis of the backbone structure of dimeric sialyl Lewis a. It plays dominant roles in L-selectin ligand biosynthesis, lymphocyte homing and lymphocyte trafficking. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for B3GNT3

Proteins

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
Refseq ID NP_055071
Protein GI 92091604
UniProt ID Q9Y2A9
mRNA ID NM_014256
Length 372
RefSeq Status REVIEWED
MKYLRHRRPNATLILAIGAFTLLLFSLLVSPPTCKVQEQPPAIPEALAWPTPPTRPAPAPCHANTSMVTHPDFATQPQHVQNFLLYRHCRHFPLLQDVPPSKCAQPVFLLLVIKSSPSNYVRRELLRRTWGRERKVRGLQLRLLFLVGTASNPHEARKVNRLLELEAQTHGDILQWDFHDSFFNLTLKQVLFLQWQETRCANASFVLNGDDDVFAHTDNMVFYLQDHDPGRHLFVGQLIQNVGPIRAFWSKYYVPEVVTQNERYPPYCGGGGFLLSRFTAAALRRAAHVLDIFPIDDVFLGMCLELEGLKPASHSGIRTSGVRAPSQRLSSFDPCFYRDLLLVHRFLPYEMLLMWDALNQPNLTCGNQTQIY

Gene Information

Entrez Gene ID
10331
Gene Name
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
Gene Symbol
B3GNT3
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0000139 TAS:Reactome C Golgi membrane
GO:0005887 TAS:ProtInc C integral component of plasma membrane
GO:0047223 IEA:UniProtKB-EC F beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity
GO:0008378 IEA:InterPro F galactosyltransferase activity
GO:0005975 TAS:Reactome P carbohydrate metabolic process
GO:0044267 TAS:Reactome P cellular protein metabolic process
GO:0030203 TAS:Reactome P glycosaminoglycan metabolic process
GO:0018146 TAS:Reactome P keratan sulfate biosynthetic process
GO:0042339 TAS:Reactome P keratan sulfate metabolic process
GO:0016266 TAS:Reactome P O-glycan processing
GO:0043687 TAS:Reactome P post-translational protein modification
GO:0044281 TAS:Reactome P small molecule metabolic process

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_121315 Glycosaminoglycan metabolism
REACT_121120 Keratan sulfate biosynthesis
REACT_121288 Keratan sulfate/keratin metabolism
REACT_200727 O-linked glycosylation

Domain Information

InterPro Annotations

Accession Description
IPR002659 Glycosyl transferase, family 31

UniProt Annotations

Entry Information

Gene Name
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
Protein Entry
B3GN3_HUMAN
UniProt ID
Q9Y2A9
Species
Human

Comments

Comment Type Description
Catalytic Activity UDP-N-acetyl-D-glucosamine + beta-D- galactosyl-(1->3)-(N-acetyl-D-glucosaminyl-(1->6))-N-acetyl-D- galactosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta- D-galactosyl-(1->3)-(N-acetyl-D-glucosaminyl-(1->6))-N-acetyl-D- galactosaminyl-R.
Function Has a beta-1,3-N-acetylglucosaminyltransferase activity for type 2 oligosaccharides.
Pathway Protein modification; protein glycosylation.
Sequence Caution Sequence=CAC82374.1; Type=Frameshift; Positions=194, 196, 202, 204, 209, 215; Evidence= ;
Similarity Belongs to the glycosyltransferase 31 family.
Subcellular Location Golgi apparatus membrane ; Single-pass type II membrane protein .
Tissue Specificity Expressed in colon, jejunum, stomach, esophagus, placenta and trachea.
Web Resource Name=Functional Glycomics Gateway - GTase; Note=UDP- GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_536";
Web Resource Name=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B3GNT3";

Identical and Related Proteins

Unique RefSeq proteins for LMP001971 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
92091604 RefSeq NP_055071 372 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3

Identical Sequences to LMP001971 proteins

Reference Database Accession Length Protein Name
GI:92091604 DBBJ BAB21531.1 372 beta-1,3-N-acetylglucosaminyltransferase bGnT-3 [Homo sapiens]
GI:92091604 DBBJ BAG36971.1 372 unnamed protein product [Homo sapiens]
GI:92091604 GenBank ABE22280.1 372 Sequence 3 from patent US 7005279
GI:92091604 GenBank ADT47434.1 372 Sequence 1095 from patent US 7842466
GI:92091604 GenBank AEK14088.1 372 Sequence 3 from patent US 7972815
GI:92091604 SwissProt Q9Y2A9.2 372 RecName: Full=UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3; Short=BGnT-3; Short=Beta-1,3-Gn-T3; Short=Beta-1,3-N-acetylglucosaminyltransferase 3; Short=Beta3Gn-T3; AltName: Full=Beta-1,3-galactosyltransferase 8; Short=Beta-1,3-GalTase 8; Short=Beta3Gal-T8; Short=Beta3GalT8; Short=b3Gal-T8; AltName: Full=Beta-3-Gx-T8; AltName: Full=Core 1 extending beta-1,3-N-acetylglucosaminyltransferase; AltName: Full=Core1-beta3GlcNAcT; AltName: Full=Transmembrane protein 3; AltName: Full=UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 8; AltName: Full=UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 8 [Homo sapiens]

Related Sequences to LMP001971 proteins

Reference Database Accession Length Protein Name
GI:92091604 EMBL CAC45044.1 372 beta-1,3-galactosyltransferase [Homo sapiens]
GI:92091604 GenBank AAK00849.1 372 core 1 extending beta-1,3-N-acetylglucosaminyltransferase [Homo sapiens]
GI:92091604 GenBank ACG89668.1 372 Sequence 288 from patent US 7385033
GI:92091604 GenBank ACG93156.1 372 Sequence 288 from patent US 7388073
GI:92091604 GenBank ACH02175.1 372 Sequence 288 from patent US 7390886
GI:92091604 GenBank ACW23822.1 372 Sequence 288 from patent US 7563867