Gene/Proteome Database (LMPD)

LMPD ID
LMP001974
Gene ID
35
Species
Homo sapiens (Human)
Gene Name
acyl-CoA dehydrogenase, C-2 to C-3 short chain
Gene Symbol
ACADS
Synonyms
ACAD3; SCAD
Chromosome
12
Map Location
12q24.31
Summary
This gene encodes a tetrameric mitochondrial flavoprotein, which is a member of the acyl-CoA dehydrogenase family. This enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Mutations in this gene have been associated with short-chain acyl-CoA dehydrogenase (SCAD) deficiency. Alternative splicing results in two variants which encode different isoforms. [provided by RefSeq, Oct 2014]
Orthologs
View orthologs and multiple alignments for ACADS

Proteins

short-chain specific acyl-CoA dehydrogenase, mitochondrial isoform 1 precursor
Refseq ID NP_000008
Protein GI 4557233
UniProt ID P16219
mRNA ID NM_000017
Length 412
RefSeq Status REVIEWED
MAAALLARASGPARRALCPRAWRQLHTIYQSVELPETHQMLLQTCRDFAEKELFPIAAQVDKEHLFPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGCASTGVIMSVNNSLYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTARAEGDSWVLNGTKAWITNAWEASAAVVFASTDRALQNKGISAFLVPMPTPGLTLGKKEDKLGIRGSSTANLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTALDCAVNYAENRMAFGAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEAAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLLRSYRS
short-chain specific acyl-CoA dehydrogenase, mitochondrial isoform 2 precursor
Refseq ID NP_001289483
Protein GI 4557233
UniProt ID P16219
mRNA ID NM_001302554
Length 412
RefSeq Status REVIEWED
MAAALLARASGPARRALCPRAWRQLHTIYQSVELPETHQMLLQTCRDFAEKELFPIAAQVDKEHLFPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGCASTGVIMSVNNSLYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTARAEGDSWVLNGTKAWITNAWEASAAVVFASTDRALQNKGISAFLVPMPTPGLTLGKKEDKLGIRGSSTANLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTALDCAVNYAENRMAFGAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEAAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLLRSYRS

Gene Information

Entrez Gene ID
35
Gene Name
acyl-CoA dehydrogenase, C-2 to C-3 short chain
Gene Symbol
ACADS
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0031966 IEA:Ensembl C mitochondrial membrane
GO:0003995 IEA:InterPro F acyl-CoA dehydrogenase activity
GO:0000062 IEA:Ensembl F fatty-acyl-CoA binding
GO:0050660 IEA:InterPro F flavin adenine dinucleotide binding
GO:0046359 IEA:Ensembl P butyrate catabolic process
GO:0033539 IEA:Ensembl P fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO:0051289 IEA:Ensembl P protein homotetramerization
GO:0051384 IEA:Ensembl P response to glucocorticoid
GO:0042594 IEA:Ensembl P response to starvation

KEGG Pathway Links

KEGG Pathway ID Description
hsa01200 Carbon metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_419 Beta oxidation of butanoyl-CoA to acetyl-CoA
REACT_1887 Beta oxidation of hexanoyl-CoA to butanoyl-CoA

Domain Information

InterPro Annotations

Accession Description
IPR006089 Acyl-CoA dehydrogenase, conserved site
IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain
IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain

UniProt Annotations

Entry Information

Gene Name
acyl-CoA dehydrogenase, C-2 to C-3 short chain
Protein Entry
ACADS_HUMAN
UniProt ID
P16219
Species
Human

Identical and Related Proteins

Unique RefSeq proteins for LMP001974 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
4557233 RefSeq NP_000008 412 short-chain specific acyl-CoA dehydrogenase, mitochondrial isoform 1 precursor
4557233 RefSeq NP_001289483 412 short-chain specific acyl-CoA dehydrogenase, mitochondrial isoform 2 precursor

Identical Sequences to LMP001974 proteins

Reference Database Accession Length Protein Name
GI:4557233 GenBank ADP91852.1 412 mitochondrial short-chain specific acyl-CoA dehydrogenase [Homo sapiens]
GI:4557233 GenBank ADP91852.1 412 mitochondrial short-chain specific acyl-CoA dehydrogenase [Homo sapiens]
GI:4557233 GenBank AEQ84536.1 412 Sequence 29 from patent US 8039587
GI:4557233 GenBank AEQ84536.1 412 Sequence 29 from patent US 8039587
GI:4557233 GenBank AEU53399.1 412 Sequence 29 from patent US 8062891
GI:4557233 GenBank AEU53399.1 412 Sequence 29 from patent US 8062891
GI:4557233 GenBank AGO72352.1 412 Sequence 29 from patent US 8470972
GI:4557233 GenBank AGO72352.1 412 Sequence 29 from patent US 8470972
GI:4557233 GenBank AGU32343.1 412 Sequence 29 from patent US 8507277
GI:4557233 GenBank AGU32343.1 412 Sequence 29 from patent US 8507277
GI:4557233 GenBank AGX48247.1 412 Sequence 29 from patent US 8541550
GI:4557233 GenBank AGX48247.1 412 Sequence 29 from patent US 8541550

Related Sequences to LMP001974 proteins

Reference Database Accession Length Protein Name
GI:4557233 GenBank ABM86304.1 412 acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain, partial [synthetic construct]
GI:4557233 GenBank ABM86304.1 412 acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain, partial [synthetic construct]
GI:4557233 GenBank ADP91826.1 412 mitochondrial short-chain specific acyl-CoA dehydrogenase [Homo sapiens]
GI:4557233 GenBank ADP91826.1 412 mitochondrial short-chain specific acyl-CoA dehydrogenase [Homo sapiens]
GI:4557233 GenBank ADP91837.1 412 mitochondrial short-chain specific acyl-CoA dehydrogenase [Homo sapiens]
GI:4557233 GenBank ADP91837.1 412 mitochondrial short-chain specific acyl-CoA dehydrogenase [Homo sapiens]
GI:4557233 GenBank ADP91850.1 412 mitochondrial short-chain specific acyl-CoA dehydrogenase [Homo sapiens]
GI:4557233 GenBank ADP91850.1 412 mitochondrial short-chain specific acyl-CoA dehydrogenase [Homo sapiens]
GI:4557233 GenBank ADP91853.1 412 mitochondrial short-chain specific acyl-CoA dehydrogenase [Homo sapiens]
GI:4557233 GenBank ADP91853.1 412 mitochondrial short-chain specific acyl-CoA dehydrogenase [Homo sapiens]
GI:4557233 GenBank AIC53941.1 412 ACADS, partial [synthetic construct]
GI:4557233 GenBank AIC53941.1 412 ACADS, partial [synthetic construct]