Gene/Proteome Database (LMPD)

LMPD ID
LMP001983
Gene ID
64816
Species
Homo sapiens (Human)
Gene Name
cytochrome P450, family 3, subfamily A, polypeptide 43
Gene Symbol
CYP3A43
Synonyms
-
Alternate Names
cytochrome P450 3A43; cytochrome P450, subfamily IIIA, polypeptide 43
Chromosome
7
Map Location
7q21.1
EC Number
1.14.14.1
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein has a low level of testosterone hydroxylase activity, and may play a role in aging mechanisms and cancer progression. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Orthologs
View orthologs and multiple alignments for CYP3A43

Proteins

cytochrome P450 3A43 isoform 1
Refseq ID NP_073731
Protein GI 12383060
UniProt ID Q9HB55
mRNA ID NM_022820
Length 504
RefSeq Status REVIEWED
MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVLKVHLRDGITSGP
cytochrome P450 3A43 isoform 2
Refseq ID NP_476436
Protein GI 16933533
UniProt ID Q9HB55
mRNA ID NM_057095
Length 503
RefSeq Status REVIEWED
MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVLKVHLRDGITSGP
cytochrome P450 3A43 isoform 3
Refseq ID NP_476437
Protein GI 16933535
UniProt ID Q9HB55
mRNA ID NM_057096
Length 420
RefSeq Status REVIEWED
MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERSH
cytochrome P450 3A43 isoform 4
Refseq ID NP_001265850
Protein GI 525458843
UniProt ID Q9HB55
mRNA ID NM_001278921
Length 393
RefSeq Status REVIEWED
MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRRSLNKIPSWAWWLTPVIPALWEAEAGGSPKVRSSRPALPTWVFGILTENVMKNTEKCGALFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVLKVHLRDGITSGP

Gene Information

Entrez Gene ID
64816
Gene Name
cytochrome P450, family 3, subfamily A, polypeptide 43
Gene Symbol
CYP3A43
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0070330 IEA:UniProtKB-EC F aromatase activity
GO:0020037 IEA:InterPro F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0004497 ISS:UniProtKB F monooxygenase activity
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0006805 TAS:Reactome P xenobiotic metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa05204 Chemical carcinogenesis
ko05204 Chemical carcinogenesis

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_13425 Miscellaneous substrates

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR008072 Cytochrome P450, E-class, CYP3A
IPR002401 Cytochrome P450, E-class, group I
IPR002402 Cytochrome P450, E-class, group II
IPR017972 Cytochrome P450, conserved site

UniProt Annotations

Entry Information

Gene Name
cytochrome P450, family 3, subfamily A, polypeptide 43
Protein Entry
CP343_HUMAN
UniProt ID
Q9HB55
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=5; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q9HB55-1; Sequence=Displayed; Name=2; IsoId=Q9HB55-2; Sequence=VSP_000609; Name=3; IsoId=Q9HB55-3; Sequence=VSP_000610, VSP_000611; Name=4; IsoId=Q9HB55-4; Sequence=VSP_000612, VSP_000613; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=7; IsoId=Q9HB55-6; Sequence=VSP_056736;
Catalytic Activity RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.
Cofactor Name=heme; Xref=ChEBI
Function Exhibits low testosterone 6-beta-hydroxylase activity.
Induction By rifampicin.
Miscellaneous Chimeric transcripts, characterized by CYP3A43 exon 1 joined at canonical splice sites to distinct sets of CYP3A4 or CYP3A5 exons, have been detected. All are possibly produced by trans-splicing. CYP3A43-CYP3A4 chimeric transcripts exist in 3 different combinations: CYP3A43 exon 1 joined in frame to CYP3A4 exons 2-13, CYP3A43 exon 1 joined in frame to CYP3A4 exons 4-13 and CYP3A43 exon 1 joined in frame to CYP3A4 exon 7-13. The longest chimeric isoform (CYP3A43 exon 1 joined to CYP3A4 exons 2- 13) exhibits 6-beta-hydroxylase activity, while a shorter isoform (CYP3A43 exon 1 joined to CYP3A4 exons 4-13) does not. CYP3A43- CYP3A5 chimeric transcripts exist in 2 different combinations: CYP3A43 exon 1 joined in frame to CYP3A5 exon 11-13 and CYP3A43 exon 1 joined in frame to CYP3A5 exon 12-13. All chimeric transcripts are expressed at very low levels in the liver (PubMed:11726664).
Polymorphism At protein level, three alleles are known: CYP3A43*1, CYP3A43*2 and CYP3A43*3. The sequence shown is that of CYP3A43*1, which is the most frequent allele. The allele CYP3A43*2 is likely to be non-functional.
Similarity Belongs to the cytochrome P450 family.
Subcellular Location Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue Specificity Highest expression level in prostate. Also expressed in liver, kidney, pancreas, fetal liver and fetal skeletal muscle. {ECO
Web Resource Name=Cytochrome P450 Allele Nomenclature Committee; Note=CYP3A43 alleles; URL="http://www.cypalleles.ki.se/cyp3a43.htm";

Identical and Related Proteins

Unique RefSeq proteins for LMP001983 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
12383060 RefSeq NP_073731 504 cytochrome P450 3A43 isoform 1
16933533 RefSeq NP_476436 503 cytochrome P450 3A43 isoform 2
16933535 RefSeq NP_476437 420 cytochrome P450 3A43 isoform 3
525458843 RefSeq NP_001265850 393 cytochrome P450 3A43 isoform 4

Identical Sequences to LMP001983 proteins

Reference Database Accession Length Protein Name
GI:12383060 GenBank AAG33010.1 504 cytochrome P450 subfamily IIIA polypeptide 43 [Homo sapiens]
GI:16933535 GenBank AAG33011.1 420 cytochrome P450 subfamily IIIA polypeptide 43 [Homo sapiens]
GI:16933533 GenBank AAQ92353.1 503 cytochrome P450 CYP3A43.1 [Homo sapiens]
GI:16933533 GenBank AAR76560.1 503 Sequence 2 from patent US 6645745
GI:12383060 GenBank AAR76561.1 504 Sequence 4 from patent US 6645745
GI:16933535 GenBank AAR76562.1 420 Sequence 6 from patent US 6645745
GI:12383060 GenBank AAS07394.1 504 unknown [Homo sapiens]
GI:16933533 GenBank AAS07395.1 503 unknown [Homo sapiens]
GI:525458843 GenBank AAI00982.1 393 CYP3A43 protein [Homo sapiens]
GI:16933535 GenBank EAW76631.1 420 cytochrome P450, family 3, subfamily A, polypeptide 43, isoform CRA_b [Homo sapiens]
GI:16933533 GenBank EAW76632.1 503 cytochrome P450, family 3, subfamily A, polypeptide 43, isoform CRA_c [Homo sapiens]
GI:12383060 GenBank EAW76634.1 504 cytochrome P450, family 3, subfamily A, polypeptide 43, isoform CRA_e [Homo sapiens]
GI:12383060 GenBank AHD77999.1 504 Sequence 24978 from patent US 8586006
GI:16933533 GenBank AHD78000.1 503 Sequence 24979 from patent US 8586006
GI:16933535 GenBank AHD78001.1 420 Sequence 24980 from patent US 8586006
GI:525458843 GenBank AIC60624.1 393 CYP3A43, partial [synthetic construct]
GI:16933533 SwissProt Q9HB55.1 503 RecName: Full=Cytochrome P450 3A43 [Homo sapiens]

Related Sequences to LMP001983 proteins

Reference Database Accession Length Protein Name
GI:16933535 GenBank AAG33009.1 503 cytochrome P450 subfamily IIIA polypeptide 43 [Homo sapiens]
GI:12383060 GenBank AAG33009.1 503 cytochrome P450 subfamily IIIA polypeptide 43 [Homo sapiens]
GI:12383060 GenBank AAK00325.1 503 cytochrome P450 CYP3A43 [Homo sapiens]
GI:16933535 GenBank AAK00325.1 503 cytochrome P450 CYP3A43 [Homo sapiens]
GI:12383060 GenBank AAK38841.1 503 cytochrome P450 subfamily IIIA polypeptide 43 [Homo sapiens]
GI:16933535 GenBank AAK38841.1 503 cytochrome P450 subfamily IIIA polypeptide 43 [Homo sapiens]
GI:16933533 GenBank AAQ92352.1 503 cytochrome P450 CYP3A43.3 [Homo sapiens]
GI:16933533 GenBank AAR76561.1 504 Sequence 4 from patent US 6645745
GI:16933533 GenBank AAS07394.1 504 unknown [Homo sapiens]
GI:525458843 GenBank EAW76632.1 503 cytochrome P450, family 3, subfamily A, polypeptide 43, isoform CRA_c [Homo sapiens]
GI:16933533 GenBank EAW76634.1 504 cytochrome P450, family 3, subfamily A, polypeptide 43, isoform CRA_e [Homo sapiens]
GI:16933533 GenBank AHD77999.1 504 Sequence 24978 from patent US 8586006
GI:12383060 GenBank AHD78000.1 503 Sequence 24979 from patent US 8586006
GI:16933535 GenBank AHD78000.1 503 Sequence 24979 from patent US 8586006
GI:16933533 RefSeq NP_073731.1 504 cytochrome P450 3A43 isoform 1 [Homo sapiens]
GI:12383060 RefSeq NP_476436.1 503 cytochrome P450 3A43 isoform 2 [Homo sapiens]
GI:16933535 RefSeq NP_476436.1 503 cytochrome P450 3A43 isoform 2 [Homo sapiens]
GI:525458843 RefSeq XP_005549229.1 393 PREDICTED: cytochrome P450 3A43-like isoform X3 [Macaca fascicularis]
GI:525458843 RefSeq XP_008966992.1 453 PREDICTED: cytochrome P450 3A43 isoform X5 [Pan paniscus]
GI:525458843 RefSeq XP_009200929.1 393 PREDICTED: cytochrome P450 3A43-like [Papio anubis]
GI:525458843 RefSeq XP_009240872.1 393 PREDICTED: cytochrome P450 3A43 isoform X4 [Pongo abelii]
GI:525458843 RefSeq XP_009452013.1 491 PREDICTED: cytochrome P450 3A43 isoform X5 [Pan troglodytes]
GI:12383060 SwissProt Q9HB55.1 503 RecName: Full=Cytochrome P450 3A43 [Homo sapiens]
GI:16933535 SwissProt Q9HB55.1 503 RecName: Full=Cytochrome P450 3A43 [Homo sapiens]