Gene/Proteome Database (LMPD)
LMPD ID
LMP001984
Gene ID
Species
Homo sapiens (Human)
Gene Name
hydroxysteroid (17-beta) dehydrogenase 7
Gene Symbol
Synonyms
PRAP; SDR37C1
Alternate Names
3-keto-steroid reductase; 17-beta-HSD 7; estradiol 17-beta-dehydrogenase 7; 17beta hydroxysteroid dehydrogenase; 17-beta-hydroxysteroid dehydrogenase 7; 17 beta-hydroxysteroid dehydrogenase type VII; short chain dehydrogenase/reductase family 37C, member 1
Chromosome
1
Map Location
1q23
EC Number
1.1.1.270
Summary
HSD17B7 encodes an enzyme that functions both as a 17-beta-hydroxysteroid dehydrogenase (EC 1.1.1.62) in the biosynthesis of sex steroids and as a 3-ketosteroid reductase (EC 1.1.1.270) in the biosynthesis of cholesterol (Marijanovic et al., 2003 [PubMed 12829805]).[supplied by OMIM, May 2010]
Orthologs
Proteins
| 3-keto-steroid reductase | |
|---|---|
| Refseq ID | NP_057455 |
| Protein GI | 7705421 |
| UniProt ID | P56937 |
| mRNA ID | NM_016371 |
| Length | 341 |
| RefSeq Status | VALIDATED |
| MRKVVLITGASSGIGLALCKRLLAEDDELHLCLACRNMSKAEAVCAALLASHPTAEVTIVQVDVSNLQSVFRASKELKQRFQRLDCIYLNAGIMPNPQLNIKALFFGLFSRKVIHMFSTAEGLLTQGDKITADGLQEVFETNVFGHFILIRELEPLLCHSDNPSQLIWTSSRSARKSNFSLEDFQHSKGKEPYSSSKYATDLLSVALNRNFNQQGLYSNVACPGTALTNLTYGILPPFIWTLLMPAILLLRFFANAFTLTPYNGTEALVWLFHQKPESLNPLIKYLSATTGFGRNYIMTQKMDLDEDTAEKFYQKLLELEKHIRVTIQKTDNQARLSGSCL | |
Gene Information
Entrez Gene ID
Gene Name
hydroxysteroid (17-beta) dehydrogenase 7
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005789 | TAS:Reactome | C | endoplasmic reticulum membrane |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0005886 | IEA:UniProtKB-KW | C | plasma membrane |
| GO:0000253 | IEA:UniProtKB-EC | F | 3-keto sterol reductase activity |
| GO:0004303 | TAS:ProtInc | F | estradiol 17-beta-dehydrogenase activity |
| GO:0006695 | TAS:Reactome | P | cholesterol biosynthetic process |
| GO:0006703 | IEA:UniProtKB-UniPathway | P | estrogen biosynthetic process |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
KEGG Pathway Links
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY-6074 | zymosterol biosynthesis |
Domain Information
UniProt Annotations
Entry Information
Gene Name
hydroxysteroid (17-beta) dehydrogenase 7
Protein Entry
DHB7_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P56937-1; Sequence=Displayed; Name=2; IsoId=P56937-2; Sequence=VSP_006029; Name=3; IsoId=P56937-3; Sequence=VSP_012766; |
| Catalytic Activity | 17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H. |
| Catalytic Activity | A 3-beta-hydroxysteroid + NADP(+) = a 3- oxosteroid + NADPH. |
| Function | Responsible for the reduction of the keto group on the C-3 of sterols. |
| Pathway | Steroid biosynthesis; estrogen biosynthesis. |
| Pathway | Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 5/6. |
| Ptm | Phosphorylated. |
| Similarity | Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily. |
| Subcellular Location | Cell membrane; Single-pass membrane protein. |
| Tissue Specificity | Highly expressed in adrenal gland, liver, lung and thymus. Expressed in breast, ovaries, pituitary gland, pregnant uterus, prostate, kidney, lymph node, small intestine, spinal cord and trachea. Weakly expressed in all other tissues tested. Isoform 3 is expressed in eye ciliary epithelial cells and neuroendocrine cells. |
Identical and Related Proteins
Unique RefSeq proteins for LMP001984 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 7705421 | RefSeq | NP_057455 | 341 | 3-keto-steroid reductase |
Identical Sequences to LMP001984 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:7705421 | GenBank | ADL85724.1 | 341 | Sequence 256 from patent US 7704496 |
| GI:7705421 | GenBank | ADL95809.1 | 341 | Sequence 256 from patent US 7718173 |
| GI:7705421 | GenBank | AED39336.1 | 341 | Sequence 1481 from patent US 7883858 |
| GI:7705421 | GenBank | AFL59688.1 | 341 | Sequence 256 from patent US 8106156 |
| GI:7705421 | GenBank | AIC51505.1 | 341 | HSD17B7, partial [synthetic construct] |
| GI:7705421 | GenBank | AIC56458.1 | 341 | HSD17B7, partial [synthetic construct] |
Related Sequences to LMP001984 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:7705421 | GenBank | AAP36180.1 | 342 | Homo sapiens hydroxysteroid (17-beta) dehydrogenase 7, partial [synthetic construct] |
| GI:7705421 | GenBank | AAX29487.1 | 342 | hydroxysteroid (17-beta) dehydrogenase 7, partial [synthetic construct] |
| GI:7705421 | GenBank | JAA16989.1 | 341 | hydroxysteroid (17-beta) dehydrogenase 7 [Pan troglodytes] |
| GI:7705421 | GenBank | JAA16990.1 | 341 | hydroxysteroid (17-beta) dehydrogenase 7 [Pan troglodytes] |
| GI:7705421 | GenBank | JAA16991.1 | 341 | hydroxysteroid (17-beta) dehydrogenase 7 [Pan troglodytes] |
| GI:7705421 | GenBank | JAA16992.1 | 341 | hydroxysteroid (17-beta) dehydrogenase 7 [Pan troglodytes] |