Gene/Proteome Database (LMPD)
LMPD ID
LMP002015
Gene ID
Species
Homo sapiens (Human)
Gene Name
ATPase, aminophospholipid transporter, class I, type 8B, member 3
Gene Symbol
Synonyms
ATPIK
Alternate Names
phospholipid-transporting ATPase IK; ATPase, class I, type 8B, member 3; aminophospholipid translocase ATP8B3; probable phospholipid-transporting ATPase IK; potential phospholipid-transporting ATPase IK
Chromosome
19
Map Location
19p13.3
EC Number
3.6.3.1
Summary
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to the other. This gene encodes member 3 of phospholipid-transporting ATPase 8B; other members of this protein family are located on chromosomes 1, 15 and 18. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Orthologs
Proteins
| phospholipid-transporting ATPase IK isoform 1 | |
|---|---|
| Refseq ID | NP_620168 |
| Protein GI | 44888835 |
| UniProt ID | O60423 |
| mRNA ID | NM_138813 |
| Length | 1300 |
| RefSeq Status | REVIEWED |
| MGTGPAQTPRSTRAGPEPSPAPPGPGDTGDSDVTQEGSGPAGIRGGETVIRAGMGDSPGRGAPERRHKAQPGRARKYEWRPEGPTSMGSLGQREDLQDEDRNSAFTWKVQANNRAYNGQFKEKVILCWQRKKYKTNVIRTAKYNFYSFLPLNLYEQFHRVSNLFFLIIIILQSIPDISTLPWFSLSTPMVCLLFIRATRDLVDDMGRHKSDRAINNRPCQILMGKSFKQKKWQDLCVGDVVCLRKDNIVPADMLLLASTEPSSLCYVETVDIDGETNLKFRQALMVTHKELATIKKMASFQGTVTCEAPNSRMHHFVGCLEWNDKKYSLDIGNLLLRGCRIRNTDTCYGLVIYAGFDTKIMKNCGKIHLKRTKLDLLMNKLVVVIFISVVLVCLVLAFGFGFSVKEFKDHHYYLSGVHGSSVAAESFFVFWSFLILLSVTIPMSMFILSEFIYLGNSVFIDWDVQMYYKPQDVPAKARSTSLNDHLGQVEYIFSDKTGTLTQNILTFNKCCISGRVYGPDSEATTRPKENPYLWNKFADGKLLFHNAALLHLVRTNGDEAVREFWRLLAICHTVMVRESPRERPDQLLYQAASPDEGALVTAARNFGYVFLSRTQDTVTIMELGEERVYQVLAIMDFNSTRKRMSVLVRKPEGAICLYTKGADTVIFERLHRRGAMEFATEEALAAFAQETLRTLCLAYREVAEDIYEDWQQRHQEASLLLQNRAQALQQLLGATAIEDRLQDGVPETIKCLKKSNIKIWVLTGDKQETAVNIGFACELLSENMLILEEKEISRILETYWENSNNLLTRESLSQVKLALVINGDFLDKLLVSLRKEPRALAQNVNMDEAWQELGQSRRDFLYARRLSLLCRRFGLPLAAPPAQDSRARRSSEVLQERAFVDLASKCQAVICCRVTPKQKALIVALVKKYHQVVTLAIGDGANDINMIKTADVGVGLAGQEGMQAVQNSDFVLGQFCFLQRLLLVHGRWSYVRICKFLRYFFYKSMASMMVQVWFACYNGFTGQPLYEGWFLALFNLLYSTLPVLYIGLFEQDVSAEQSLEKPELYVVGQKDELFNYWVFVQAIAHGVTTSLVNFFMTLWISRDTAGPASFSDHQSFAVVVALSCLLSITMEVILIIKYWTALCVATILLSLGFYAIMTTTTQSFWLFRVSPTTFPFLYADLSVMSSPSILLVVLLSVSINTFPVLALRVIFPALKELRAKEEKVEEGPSEEIFTMEPLPHVHRESRARRSSYAFSHREGYANLITQGTILRRGPGVSSDIASESLDPSDEEAASSPKESQ | |
| phospholipid-transporting ATPase IK isoform 2 | |
|---|---|
| Refseq ID | NP_001171473 |
| Protein GI | 295821170 |
| UniProt ID | O60423 |
| mRNA ID | NM_001178002 |
| Length | 1263 |
| RefSeq Status | REVIEWED |
| MGDSPGRGAPERRHKAQPGRARKYEWRPEGPTSMGSLGQREDLQDEDRNSAFTWKVQANNRAYNGQFKEKVILCWQRKKYKTNVIRTAKYNFYSFLPLNLYEQFHRVSNLFFLIIIILQSIPDISTLPWFSLSTPMVCLLFIRATRDLVDDMGRHKSDRAINNRPCQILMGKSFKQKKWQDLCVGDVVCLRKDNIVPADMLLLASTEPSSLCYVETVDIDGETNLKFRQALMVTHKELATIKKMASFQGTVTCEAPNSRMHHFVGCLEWNDKKYSLDIGNLLLRGCRIRNTDTCYGLVIYADGYMFVGFDTKIMKNCGKIHLKRTKLDLLMNKLVVVIFISVVLVCLVLAFGFGFSVKEFKDHHYYLSGVHGSSVAAESFFVFWSFLILLSVTIPMSMFILSEFIYLGNSVFIDWDVQMYYKPQDVPAKARSTSLNDHLGQVEYIFSDKTGTLTQNILTFNKCCISGRVYGPDSEATTRPKENPYLWNKFADGKLLFHNAALLHLVRTNGDEAVREFWRLLAICHTVMVRESPRERPDQLLYQAASPDEGALVTAARNFGYVFLSRTQDTVTIMELGEERVYQVLAIMDFNSTRKRMSVLVRKPEGAICLYTKGADTVIFERLHRRGAMEFATEEALAAFAQETLRTLCLAYREVAEDIYEDWQQRHQEASLLLQNRAQALQQVYNEMEQDLRLLGATAIEDRLQDGVPETIKCLKKSNIKIWVLTGDKQETAVNIGFACELLSENMLILEEKEISRILETYWENSNNLLTRESLSQVKLALVINGDFLDKLLVSLRKEPRALAQNVNMDEAWQELGQSRRDFLYARRLSLLCRRFGLPLAAPPAQDSRARRSSEVLQERAFVDLASKCQAVICCRVTPKQKALIVALVKKYHQVVTLAIGDGANDINMIKTADVGVGLAGQEGMQAVQNSDFVLGQFCFLQRLLLVHGRWSYVRICKFLRYFFYKSMASMMVQVWFACYNGFTGQPLYEGWFLALFNLLYSTLPVLYIGLFEQDVSAEQSLEKPELYVVGQKDELFNYWVFVQAIAHGVTTSLVNFFMTLWISRDTAGPASFSDHQSFAVVVALSCLLSITMEVILIIKYWTALCVATILLSLGFYAIMTTTTQSFWLFRVSPTTFPFLYADLSVMSSPSILLVVLLSVSINTFPVLALRVIFPALKELRAKEEKVEEGPSEEIFTMEPLPHVHRESRARRSSYAFSHREGYANLITQGTILRRGPGVSSDIASESLDPSDEEAASSPKESQ | |
Gene Information
Entrez Gene ID
Gene Name
ATPase, aminophospholipid transporter, class I, type 8B, member 3
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0001669 | IEA:Ensembl | C | acrosomal vesicle |
| GO:0005783 | IEA:UniProtKB-KW | C | endoplasmic reticulum |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
| GO:0019829 | IEA:InterPro | F | cation-transporting ATPase activity |
| GO:0000287 | IEA:InterPro | F | magnesium ion binding |
| GO:0004012 | IEA:UniProtKB-EC | F | phospholipid-translocating ATPase activity |
| GO:0007339 | IEA:Ensembl | P | binding of sperm to zona pellucida |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_25300 | Ion channel transport |
| REACT_25149 | Ion transport by P-type ATPases |
| REACT_15518 | Transmembrane transport of small molecules |
Domain Information
UniProt Annotations
Entry Information
Gene Name
ATPase, aminophospholipid transporter, class I, type 8B, member 3
Protein Entry
AT8B3_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O60423-2; Sequence=Displayed; Name=2; IsoId=O60423-1; Sequence=VSP_039716; Note=No experimental confirmation available.; Name=3; IsoId=O60423-3; Sequence=VSP_043554, VSP_043555, VSP_039716; Note=No experimental confirmation available.; |
| Catalytic Activity | ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). |
| Function | P4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May be responsible for the maintenance of asymmetric distribution of phosphatidylserine (PS) in spermatozoa membranes. Involved in acrosome reactions and binding of spermatozoa to zona pellucida (By similarity). |
| Miscellaneous | Association with flippase complex beta subunits TMEM30A and TMEM30A has not been detected, neither did their coexpression change the localization in ER. |
| Sequence Caution | Sequence=AAC17601.1; Type=Erroneous gene model prediction; Evidence= ; Sequence=BAB71492.1; Type=Erroneous initiation; Evidence= ; |
| Similarity | Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. |
| Subcellular Location | Cytoplasmic vesicle, secretory vesicle, acrosome membrane ; Multi-pass membrane protein . Endoplasmic reticulum . |
| Tissue Specificity | Isoform 3 was only detected in testis. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002015 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 44888835 | RefSeq | NP_620168 | 1300 | phospholipid-transporting ATPase IK isoform 1 |
| 295821170 | RefSeq | NP_001171473 | 1263 | phospholipid-transporting ATPase IK isoform 2 |
Identical Sequences to LMP002015 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:295821170 | GenBank | AAQ19028.1 | 1263 | possible aminophospholipid translocase ATP8B3 [Homo sapiens] |
| GI:44888835 | GenBank | AAH35162.3 | 1300 | ATPase, class I, type 8B, member 3 [Homo sapiens] |
| GI:295821170 | GenBank | EAW69455.1 | 1263 | ATPase, Class I, type 8B, member 3, isoform CRA_b [Homo sapiens] |
| GI:44888835 | GenBank | AHD71258.1 | 1300 | Sequence 5952 from patent US 8586006 |
| GI:44888835 | SwissProt | O60423.4 | 1300 | RecName: Full=Phospholipid-transporting ATPase IK; AltName: Full=ATPase class I type 8B member 3 [Homo sapiens] |
Related Sequences to LMP002015 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:295821170 | GenBank | AAH35162.3 | 1300 | ATPase, class I, type 8B, member 3 [Homo sapiens] |
| GI:44888835 | GenBank | EAW69455.1 | 1263 | ATPase, Class I, type 8B, member 3, isoform CRA_b [Homo sapiens] |
| GI:44888835 | GenBank | EAW69457.1 | 1300 | ATPase, Class I, type 8B, member 3, isoform CRA_d [Homo sapiens] |
| GI:44888835 | GenBank | EAW69459.1 | 1310 | ATPase, Class I, type 8B, member 3, isoform CRA_f, partial [Homo sapiens] |
| GI:295821170 | GenBank | EAW69459.1 | 1310 | ATPase, Class I, type 8B, member 3, isoform CRA_f, partial [Homo sapiens] |
| GI:295821170 | RefSeq | NP_620168.1 | 1300 | phospholipid-transporting ATPase IK isoform 1 [Homo sapiens] |
| GI:44888835 | RefSeq | NP_001171473.1 | 1263 | phospholipid-transporting ATPase IK isoform 2 [Homo sapiens] |
| GI:295821170 | RefSeq | XP_006722717.1 | 1310 | PREDICTED: probable phospholipid-transporting ATPase IK isoform X1 [Homo sapiens] |
| GI:44888835 | RefSeq | XP_006722717.1 | 1310 | PREDICTED: probable phospholipid-transporting ATPase IK isoform X1 [Homo sapiens] |
| GI:295821170 | RefSeq | XP_006722718.1 | 1310 | PREDICTED: probable phospholipid-transporting ATPase IK isoform X2 [Homo sapiens] |
| GI:44888835 | RefSeq | XP_006722718.1 | 1310 | PREDICTED: probable phospholipid-transporting ATPase IK isoform X2 [Homo sapiens] |
| GI:295821170 | SwissProt | O60423.4 | 1300 | RecName: Full=Phospholipid-transporting ATPase IK; AltName: Full=ATPase class I type 8B member 3 [Homo sapiens] |