Gene/Proteome Database (LMPD)

LMPD ID
LMP002037
Gene ID
20905
Species
Mus musculus (Mouse)
Gene Name
steroid sulfatase
Gene Symbol
Sts
Synonyms
ArsC
Alternate Names
steryl-sulfatase; ASC; arylsulfatase C; steryl-sulfate sulfohydrolase
Chromosome
X|Y
Map Location
X;Y|XY 75.0 cM
EC Number
3.1.6.2

Proteins

steryl-sulfatase precursor
Refseq ID NP_033319
Protein GI 6678175
UniProt ID P50427
mRNA ID NM_009293
Length 624
RefSeq Status PROVISIONAL
MPRPRPLLLAVMAATLADIILAADPAPAGPAPRPPNFLLIMADDLGIGDLGCYGNKTLRTPHLDRLAREGVKLTQHLAAAPLCTPSRAAFLTGRYPPRSGMAAHGRVGVYLFTASSGGLPPSEVTMARLLKGRGYATALIGKWHLGLSCRGATDFCHHPLRHGFDRFLGVPTTNLRDCRPGAGTVFGPALRVFAAGPLAALGASLAAMAAARWAGLARVPGWALAGTAAAMLAVGGPRSASCLGFRPANCFLMDDLAVAQRPTDYGGLTRRLADEAALFLRRNRARPFLLFLSFLHVHTAHFADPGFAGRSLHGAYGDSVEEMDWGVGRVLAALDELGLARETLVYFTSDHGAHVEELGPRGERMGGSNGVFRGGKGNNWEGGVRVPCLVRWPRELSPGRVVAEPTSLMDVFPTVARLAGAELPGDRVIDGRDLMPLLRGDAQRSEHEFLFHYCNAYLQAVRWHNGSAVWKAFYFTPNFAPAGANGCFSTHVCLCAGPAHVTAHDPPLLFDLTRDPGERRPLTPEAEPRHREVLDAIDAAARAHRARLRPAPDQLAPRHLMWKPWLQLWGGGGAGGGAGAQDDSGHAHGDGSHAHDDPGHAQDRGDDDAHYGGHATTRTQATPR
sig_peptide: 1..22 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2347 peptide sequence: MPRPRPLLLAVMAATLADIILA mat_peptide: 23..624 product: Steryl-sulfatase experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P50427.1) calculated_mol_wt: 64262 peptide sequence: ADPAPAGPAPRPPNFLLIMADDLGIGDLGCYGNKTLRTPHLDRLAREGVKLTQHLAAAPLCTPSRAAFLTGRYPPRSGMAAHGRVGVYLFTASSGGLPPSEVTMARLLKGRGYATALIGKWHLGLSCRGATDFCHHPLRHGFDRFLGVPTTNLRDCRPGAGTVFGPALRVFAAGPLAALGASLAAMAAARWAGLARVPGWALAGTAAAMLAVGGPRSASCLGFRPANCFLMDDLAVAQRPTDYGGLTRRLADEAALFLRRNRARPFLLFLSFLHVHTAHFADPGFAGRSLHGAYGDSVEEMDWGVGRVLAALDELGLARETLVYFTSDHGAHVEELGPRGERMGGSNGVFRGGKGNNWEGGVRVPCLVRWPRELSPGRVVAEPTSLMDVFPTVARLAGAELPGDRVIDGRDLMPLLRGDAQRSEHEFLFHYCNAYLQAVRWHNGSAVWKAFYFTPNFAPAGANGCFSTHVCLCAGPAHVTAHDPPLLFDLTRDPGERRPLTPEAEPRHREVLDAIDAAARAHRARLRPAPDQLAPRHLMWKPWLQLWGGGGAGGGAGAQDDSGHAHGDGSHAHDDPGHAQDRGDDDAHYGGHATTRTQATPR

Gene Information

Entrez Gene ID
20905
Gene Name
steroid sulfatase
Gene Symbol
Sts
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0004773 IEA:UniProtKB-EC F steryl-sulfatase activity
GO:0008484 ISO:MGI F sulfuric ester hydrolase activity
GO:0007565 IEA:UniProtKB-KW P female pregnancy
GO:0008202 IEA:UniProtKB-KW P steroid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00140 Steroid hormone biosynthesis
mmu00140 Steroid hormone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR017849 Alkaline phosphatase-like, alpha/beta/alpha
IPR017850 Alkaline-phosphatase-like, core domain
IPR000917 Sulfatase
IPR024607 Sulfatase, conserved site

UniProt Annotations

Entry Information

Gene Name
steroid sulfatase
Protein Entry
STS_MOUSE
UniProt ID
P50427
Species
Mouse

Comments

Comment Type Description
Catalytic Activity 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H(2)O = 3-beta-hydroxyandrost-5-en-17-one + sulfate.
Cofactor Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000250};
Function Conversion of sulfated steroid precursors to estrogens during pregnancy.
Ptm The conversion to 3-oxoalanine (also known as C- formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. {ECO:0000250}.
Similarity Belongs to the sulfatase family. {ECO:0000305}.
Subcellular Location Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=The sequence shows several membrane-spanning domains that could serve to anchor the protein in the microsomal membrane.
Subunit Homodimer.

Identical and Related Proteins

Unique RefSeq proteins for LMP002037 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6678175 RefSeq NP_033319 624 steryl-sulfatase precursor

Identical Sequences to LMP002037 proteins

Reference Database Accession Length Protein Name
GI:6678175 GenBank AAB09308.1 624 steroid sulfatase [Mus musculus]
GI:6678175 SwissProt P50427.1 624 RecName: Full=Steryl-sulfatase; AltName: Full=Arylsulfatase C; Short=ASC; AltName: Full=Steroid sulfatase; AltName: Full=Steryl-sulfate sulfohydrolase; Flags: Precursor [Mus musculus]

Related Sequences to LMP002037 proteins

Reference Database Accession Length Protein Name
GI:6678175 GenBank AAC53097.1 577 steroid sulfatase [Rattus norvegicus]
GI:6678175 RefSeq NP_036793.1 577 steryl-sulfatase precursor [Rattus norvegicus]
GI:6678175 RefSeq XP_002722117.1 572 PREDICTED: steryl-sulfatase-like isoform X2 [Oryctolagus cuniculus]
GI:6678175 RefSeq XP_008247483.1 630 PREDICTED: steryl-sulfatase-like isoform X1 [Oryctolagus cuniculus]
GI:6678175 RefSeq XP_008247484.1 572 PREDICTED: steryl-sulfatase-like isoform X2 [Oryctolagus cuniculus]
GI:6678175 SwissProt P15589.2 577 RecName: Full=Steryl-sulfatase; AltName: Full=Arylsulfatase C; Short=ASC; AltName: Full=Steroid sulfatase; AltName: Full=Steryl-sulfate sulfohydrolase; Flags: Precursor [Rattus norvegicus]