Gene/Proteome Database (LMPD)
Proteins
| arylsulfatase A precursor | |
|---|---|
| Refseq ID | NP_033843 |
| Protein GI | 67972647 |
| UniProt ID | P50428 |
| mRNA ID | NM_009713 |
| Length | 506 |
| RefSeq Status | VALIDATED |
| MALGTLFLALAAGLSTASPPNILLIFADDLGYGDLGSYGHPSSTTPNLDQLAEGGLRFTDFYVPVSLCTPSRAALLTGRLPVRSGMYPGVLGPSSQGGLPLEEVTLAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPDIPCKGGCDQGLVPIPLLANLTVEAQPPWLPGLEARYVSFSRDLMADAQRQGRPFFLYYASHHTHYPQFSGQSFTKRSGRGPFGDSLMELDGAVGALMTTVGDLGLLEETLVIFTADNGPELMRMSNGGCSGLLRCGKGTTFEGGVREPALVYWPGHITPGVTHELASSLDLLPTLAALTGAPLPNVTLDGVDISPLLLGTGKSPRKSVFFYPPYPDEIHGVFAVRNGKYKAHFFTQGSAHSDTTSDPACHAANRLTAHEPPLLYDLSQDPGENYNVLESIEGVSPEALQALKHIQLLKAQYDAAMTFGPSQIAKGEDPALQICCQPSCTPHPVCCHCPGSQS | |
| sig_peptide: 1..17 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1621 peptide sequence: MALGTLFLALAAGLSTA mat_peptide: 18..506 product: Arylsulfatase A experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P50428.2) calculated_mol_wt: 52145 peptide sequence: SPPNILLIFADDLGYGDLGSYGHPSSTTPNLDQLAEGGLRFTDFYVPVSLCTPSRAALLTGRLPVRSGMYPGVLGPSSQGGLPLEEVTLAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPDIPCKGGCDQGLVPIPLLANLTVEAQPPWLPGLEARYVSFSRDLMADAQRQGRPFFLYYASHHTHYPQFSGQSFTKRSGRGPFGDSLMELDGAVGALMTTVGDLGLLEETLVIFTADNGPELMRMSNGGCSGLLRCGKGTTFEGGVREPALVYWPGHITPGVTHELASSLDLLPTLAALTGAPLPNVTLDGVDISPLLLGTGKSPRKSVFFYPPYPDEIHGVFAVRNGKYKAHFFTQGSAHSDTTSDPACHAANRLTAHEPPLLYDLSQDPGENYNVLESIEGVSPEALQALKHIQLLKAQYDAAMTFGPSQIAKGEDPALQICCQPSCTPHPVCCHCPGSQS | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0001669 | IEA:Ensembl | C | acrosomal vesicle |
| GO:0005768 | IEA:Ensembl | C | endosome |
| GO:0005615 | IEA:Ensembl | C | extracellular space |
| GO:0070062 | IEA:Ensembl | C | extracellular vesicular exosome |
| GO:0031232 | IEA:Ensembl | C | extrinsic component of external side of plasma membrane |
| GO:0016021 | IDA:MGI | C | integral component of membrane |
| GO:0005764 | IEA:UniProtKB-KW | C | lysosome |
| GO:0005886 | IDA:MGI | C | plasma membrane |
| GO:0004065 | IEA:Ensembl | F | arylsulfatase activity |
| GO:0005509 | ISS:UniProtKB | F | calcium ion binding |
| GO:0004098 | IEA:UniProtKB-EC | F | cerebroside-sulfatase activity |
| GO:0008484 | ISO:MGI | F | sulfuric ester hydrolase activity |
| GO:0006914 | IEA:Ensembl | P | autophagy |
| GO:0007339 | IMP:MGI | P | binding of sperm to zona pellucida |
| GO:0007417 | IEA:Ensembl | P | central nervous system development |
| GO:0043627 | IEA:Ensembl | P | response to estrogen |
| GO:0045471 | IEA:Ensembl | P | response to ethanol |
| GO:0051597 | IEA:Ensembl | P | response to methylmercury |
| GO:0007584 | IEA:Ensembl | P | response to nutrient |
| GO:0009268 | IEA:Ensembl | P | response to pH |
KEGG Pathway Links
REACTOME Pathway Links
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | A cerebroside 3-sulfate + H(2)O = a cerebroside + sulfate. |
| Cofactor | Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000250}; |
| Function | Hydrolyzes cerebroside sulfate. |
| Ptm | The conversion to 3-oxoalanine (also known as C- formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. {ECO:0000250}. |
| Similarity | Belongs to the sulfatase family. {ECO:0000305}. |
| Subcellular Location | Lysosome. |
| Subunit | Homodimer at neutral pH and homooctamer at acidic pH. Exists both as a single chain of 58 kDa (component A) or as a chain of 50 kDa (component B) linked by disulfide bond(s) to a 7 kDa chain (component C). Interacts with SUMF1 (By similarity). {ECO:0000250}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002038 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 67972647 | RefSeq | NP_033843 | 506 | arylsulfatase A precursor |
Identical Sequences to LMP002038 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:67972647 | DBBJ | BAB23356.1 | 506 | unnamed protein product [Mus musculus] |
| GI:67972647 | DBBJ | BAE21207.1 | 506 | unnamed protein product [Mus musculus] |
| GI:67972647 | GenBank | AAH11284.1 | 506 | Arylsulfatase A [Mus musculus] |
| GI:67972647 | GenBank | AAH98075.1 | 506 | Arylsulfatase A [Mus musculus] |
| GI:67972647 | GenBank | EDL04336.1 | 506 | arylsulfatase A, isoform CRA_b [Mus musculus] |
| GI:67972647 | SwissProt | P50428.2 | 506 | RecName: Full=Arylsulfatase A; Short=ASA; AltName: Full=Cerebroside-sulfatase; Flags: Precursor [Mus musculus] |
Related Sequences to LMP002038 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:67972647 | EMBL | CAA51703.1 | 506 | arylsulfatase A [Mus musculus] |
| GI:67972647 | EMBL | CAA51702.1 | 506 | murine arylsulfatase A [Mus musculus] |
| GI:67972647 | GenBank | EDL76575.1 | 507 | arylsulfatase A, isoform CRA_a [Rattus norvegicus] |
| GI:67972647 | GenBank | ADT54627.1 | 506 | Sequence 105 from patent US 7842783 |
| GI:67972647 | RefSeq | NP_001030105.2 | 507 | arylsulfatase A precursor [Rattus norvegicus] |
| GI:67972647 | tpe | CAI84981.1 | 507 | TPA: arylsulfatase A [Rattus norvegicus] |