Gene/Proteome Database (LMPD)

LMPD ID
LMP002040
Gene ID
4481
Species
Homo sapiens (Human)
Gene Name
macrophage scavenger receptor 1
Gene Symbol
MSR1
Synonyms
CD204; SCARA1; SR-A; SRA; phSR1; phSR2
Alternate Names
macrophage scavenger receptor types I and II; scavenger receptor class A member 1; scavenger receptor class A, member 1; macrophage scavenger receptor type III; macrophage acetylated LDL receptor I and II
Chromosome
8
Map Location
8p22
Summary
This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for MSR1

Proteins

macrophage scavenger receptor types I and II isoform type 1
Refseq ID NP_619729
Protein GI 20357512
UniProt ID P21757
mRNA ID NM_138715
Length 451
RefSeq Status REVIEWED
MEQWDHFHNQQEDTDSCSESVKFDARSMTALLPPNPKNSPSLQEKLKSFKAALIALYLLVFAVLIPLIGIVAAQLLKWETKNCSVSSTNANDITQSLTGKGNDSEEEMRFQEVFMEHMSNMEKRIQHILDMEANLMDTEHFQNFSMTTDQRFNDILLQLSTLFSSVQGHGNAIDEISKSLISLNTTLLDLQLNIENLNGKIQENTFKQQEEISKLEERVYNVSAEIMAMKEEQVHLEQEIKGEVKVLNNITNDLRLKDWEHSQTLRNITLIQGPPGPPGEKGDRGPTGESGPRGFPGPIGPPGLKGDRGAIGFPGSRGLPGYAGRPGNSGPKGQKGEKGSGNTLTPFTKVRLVGGSGPHEGRVEILHSGQWGTICDDRWEVRVGQVVCRSLGYPGVQAVHKAAHFGQGTGPIWLNEVFCFGRESSIEECKIRQWGTRACSHSEDAGVTCTL
macrophage scavenger receptor types I and II isoform type 2
Refseq ID NP_002436
Protein GI 4505259
UniProt ID P21757
mRNA ID NM_002445
Length 358
RefSeq Status REVIEWED
MEQWDHFHNQQEDTDSCSESVKFDARSMTALLPPNPKNSPSLQEKLKSFKAALIALYLLVFAVLIPLIGIVAAQLLKWETKNCSVSSTNANDITQSLTGKGNDSEEEMRFQEVFMEHMSNMEKRIQHILDMEANLMDTEHFQNFSMTTDQRFNDILLQLSTLFSSVQGHGNAIDEISKSLISLNTTLLDLQLNIENLNGKIQENTFKQQEEISKLEERVYNVSAEIMAMKEEQVHLEQEIKGEVKVLNNITNDLRLKDWEHSQTLRNITLIQGPPGPPGEKGDRGPTGESGPRGFPGPIGPPGLKGDRGAIGFPGSRGLPGYAGRPGNSGPKGQKGEKGSGNTLRPVQLTDHIRAGPS
macrophage scavenger receptor types I and II isoform type 3
Refseq ID NP_619730
Protein GI 20357515
UniProt ID P21757
mRNA ID NM_138716
Length 388
RefSeq Status REVIEWED
MEQWDHFHNQQEDTDSCSESVKFDARSMTALLPPNPKNSPSLQEKLKSFKAALIALYLLVFAVLIPLIGIVAAQLLKWETKNCSVSSTNANDITQSLTGKGNDSEEEMRFQEVFMEHMSNMEKRIQHILDMEANLMDTEHFQNFSMTTDQRFNDILLQLSTLFSSVQGHGNAIDEISKSLISLNTTLLDLQLNIENLNGKIQENTFKQQEEISKLEERVYNVSAEIMAMKEEQVHLEQEIKGEVKVLNNITNDLRLKDWEHSQTLRNITLIQGPPGPPGEKGDRGPTGESGPRGFPGPIGPPGLKGDRGAIGFPGSRGLPGYAGRPGNSGPKGQKGEKGSGNTLSTGPIWLNEVFCFGRESSIEECKIRQWGTRACSHSEDAGVTCTL

Gene Information

Entrez Gene ID
4481
Gene Name
macrophage scavenger receptor 1
Gene Symbol
MSR1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005581 IEA:UniProtKB-KW C collagen trimer
GO:0005829 IEA:Ensembl C cytosol
GO:0030666 TAS:Reactome C endocytic vesicle membrane
GO:0005887 TAS:ProtInc C integral component of plasma membrane
GO:0034362 IEA:UniProtKB-KW C low-density lipoprotein particle
GO:0005886 TAS:Reactome C plasma membrane
GO:0030169 ISS:BHF-UCL F low-density lipoprotein particle binding
GO:0005044 TAS:ProtInc F scavenger receptor activity
GO:0030301 ISS:BHF-UCL P cholesterol transport
GO:0042953 IEA:Ensembl P lipoprotein transport
GO:0034381 ISS:BHF-UCL P plasma lipoprotein particle clearance
GO:0010886 ISS:BHF-UCL P positive regulation of cholesterol storage
GO:0010744 ISS:BHF-UCL P positive regulation of macrophage derived foam cell differentiation
GO:0006898 TAS:ProtInc P receptor-mediated endocytosis

KEGG Pathway Links

KEGG Pathway ID Description
hsa04145 Phagosome

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_160300 Binding and Uptake of Ligands by Scavenger Receptors
REACT_163699 Scavenging by Class A Receptors

Domain Information

InterPro Annotations

Accession Description
IPR008160 Collagen triple helix repeat
IPR003543 Macrophage scavenger receptor
IPR001190 SRCR domain
IPR017448 SRCR-like domain

UniProt Annotations

Entry Information

Gene Name
macrophage scavenger receptor 1
Protein Entry
MSRE_HUMAN
UniProt ID
P21757
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=I; IsoId=P21757-1; Sequence=Displayed; Name=II; IsoId=P21757-2; Sequence=VSP_006229, VSP_006230; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=III; IsoId=P21757-3; Sequence=VSP_036842;
Disease Barrett esophagus (BE) [MIM
Disease Prostate cancer (PC) [MIM
Function Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize acetylated LDL.
Interaction Q86VS8:HOOK3; NbExp=4; IntAct=EBI-1776976, EBI-1777078; Q7TQ77:Hook3 (xeno); NbExp=2; IntAct=EBI-1776976, EBI-1777000;
Similarity Contains 1 SRCR domain. {ECO
Similarity Contains 1 collagen-like domain.
Subcellular Location Membrane; Single-pass type II membrane protein.
Subunit Homotrimer.
Tissue Specificity Isoform I, isoform II and isoform III are expressed in monocyte-derived macrophages.
Web Resource Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/msr1/";

Identical and Related Proteins

Unique RefSeq proteins for LMP002040 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
20357512 RefSeq NP_619729 451 macrophage scavenger receptor types I and II isoform type 1
4505259 RefSeq NP_002436 358 macrophage scavenger receptor types I and II isoform type 2
20357515 RefSeq NP_619730 388 macrophage scavenger receptor types I and II isoform type 3

Identical Sequences to LMP002040 proteins

Reference Database Accession Length Protein Name
GI:20357512 EMBL CCQ77679.1 451 unnamed protein product [Homo sapiens]
GI:20357515 GenBank AAC09251.1 388 macrophage scavenger receptor type III [Homo sapiens]
GI:20357515 GenBank EAW63832.1 388 macrophage scavenger receptor 1, isoform CRA_c [Homo sapiens]
GI:20357515 GenBank ACP57267.1 388 Sequence 1396 from patent US 7482117
GI:4505259 GenBank ACP57268.1 358 Sequence 1397 from patent US 7482117
GI:4505259 GenBank ACP57269.1 358 Sequence 1398 from patent US 7482117
GI:20357512 GenBank ADQ31955.1 451 macrophage scavenger receptor 1, partial [synthetic construct]
GI:4505259 GenBank ADS30862.1 358 Sequence 1394 from patent US 7781168
GI:20357512 GenBank ADS30863.1 451 Sequence 1395 from patent US 7781168
GI:20357515 GenBank ADS30864.1 388 Sequence 1396 from patent US 7781168
GI:4505259 GenBank ADS30865.1 358 Sequence 1397 from patent US 7781168
GI:4505259 GenBank ADS30866.1 358 Sequence 1398 from patent US 7781168
GI:20357512 GenBank AFL38876.1 451 Sequence 2 from patent US 8192928
GI:20357512 GenBank AHD75234.1 451 Sequence 16513 from patent US 8586006
GI:20357515 GenBank AHD75235.1 388 Sequence 16514 from patent US 8586006
GI:4505259 GenBank AHD78550.1 358 Sequence 26548 from patent US 8586006
GI:20357512 GenBank AIC54772.1 451 MSR1, partial [synthetic construct]

Related Sequences to LMP002040 proteins

Reference Database Accession Length Protein Name
GI:4505259 DBBJ BAA14208.1 451 scavenger receptor type I [Homo sapiens]
GI:20357512 DBBJ BAG56756.1 469 unnamed protein product [Homo sapiens]
GI:4505259 GenBank ACM83760.1 362 Sequence 9258 from patent US 6812339
GI:4505259 GenBank AFL38876.1 451 Sequence 2 from patent US 8192928
GI:20357512 pat US 451 Sequence 2 from patent US 5624904
GI:20357512 RefSeq XP_003807486.1 451 PREDICTED: macrophage scavenger receptor types I and II isoform X1 [Pan paniscus]
GI:20357515 RefSeq XP_003807487.1 388 PREDICTED: macrophage scavenger receptor types I and II isoform X2 [Pan paniscus]
GI:20357512 RefSeq XP_004046735.1 451 PREDICTED: macrophage scavenger receptor types I and II isoform 1 [Gorilla gorilla gorilla]
GI:20357515 RefSeq XP_004046736.1 388 PREDICTED: macrophage scavenger receptor types I and II isoform 2 [Gorilla gorilla gorilla]
GI:4505259 RefSeq XP_004046737.1 358 PREDICTED: macrophage scavenger receptor types I and II isoform 3 [Gorilla gorilla gorilla]
GI:20357515 RefSeq XP_004087998.1 388 PREDICTED: macrophage scavenger receptor types I and II [Nomascus leucogenys]
GI:20357515 RefSeq XP_005562707.1 388 PREDICTED: macrophage scavenger receptor types I and II isoform X4 [Macaca fascicularis]
GI:20357512 RefSeq XP_008957787.1 451 PREDICTED: macrophage scavenger receptor types I and II isoform X1 [Pan paniscus]
GI:4505259 RefSeq XP_008957788.1 358 PREDICTED: macrophage scavenger receptor types I and II isoform X3 [Pan paniscus]
GI:20357515 RefSeq XP_009453115.1 445 PREDICTED: macrophage scavenger receptor types I and II isoform X1 [Pan troglodytes]
GI:20357515 RefSeq XP_009453117.1 433 PREDICTED: macrophage scavenger receptor types I and II isoform X2 [Pan troglodytes]
GI:20357512 RefSeq XP_010356459.1 451 PREDICTED: macrophage scavenger receptor types I and II isoform X1 [Rhinopithecus roxellana]
GI:4505259 SwissProt P21757.1 451 RecName: Full=Macrophage scavenger receptor types I and II; AltName: Full=Macrophage acetylated LDL receptor I and II; AltName: Full=Scavenger receptor class A member 1; AltName: CD_antigen=CD204 [Homo sapiens]