Gene/Proteome Database (LMPD)
LMPD ID
LMP002048
Gene ID
Species
Homo sapiens (Human)
Gene Name
beta-carotene oxygenase 1
Gene Symbol
Synonyms
BCDO; BCDO1; BCMO; BCMO1; BCO
Alternate Names
beta,beta-carotene 15,15'-monooxygenase;,beta-carotene dioxygenase 1', "beta-carotene 15, 15'-dioxygenase 1", "beta-carotene 15,15'-monooxygenase 1
Chromosome
16
Map Location
16q23.2
EC Number
1.14.99.36
Summary
Vitamin A metabolism is important for vital processes such as vision, embryonic development, cell differentiation, and membrane and skin protection. The protein encoded by this gene is a key enzyme in beta-carotene metabolism to vitamin A. It catalyzes the oxidative cleavage of beta,beta-carotene into two retinal molecules. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| beta,beta-carotene 15,15'-monooxygenase | |
|---|---|
| Refseq ID | NP_059125 |
| Protein GI | 74027270 |
| UniProt ID | Q9HAY6 |
| mRNA ID | NM_017429 |
| Length | 547 |
| RefSeq Status | REVIEWED |
| MDIIFGRNRKEQLEPVRAKVTGKIPAWLQGTLLRNGPGMHTVGESRYNHWFDGLALLHSFTIRDGEVYYRSKYLRSDTYNTNIEANRIVVSEFGTMAYPDPCKNIFSKAFSYLSHTIPDFTDNCLINIMKCGEDFYATSETNYIRKINPQTLETLEKVDYRKYVAVNLATSHPHYDEAGNVLNMGTSIVEKGKTKYVIFKIPATVPEGKKQGKSPWKHTEVFCSIPSRSLLSPSYYHSFGVTENYVIFLEQPFRLDILKMATAYIRRMSWASCLAFHREEKTYIHIIDQRTRQPVQTKFYTDAMVVFHHVNAYEEDGCIVFDVIAYEDNSLYQLFYLANLNQDFKENSRLTSVPTLRRFAVPLHVDKNAEVGTNLIKVASTTATALKEEDGQVYCQPEFLYEGLELPRVNYAHNGKQYRYVFATGVQWSPIPTKIIKYDILTKSSLKWREDDCWPAEPLFVPAPGAKDEDDGVILSAIVSTDPQKLPFLLILDAKSFTELARASVDVDMHMDLHGLFITDMDWDTKKQAASEEQRDRASDCHGAPLT | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005829 | TAS:Reactome | C | cytosol |
| GO:0003834 | IDA:UniProtKB | F | beta-carotene 15,15'-monooxygenase activity |
| GO:0046872 | IEA:UniProtKB-KW | F | metal ion binding |
| GO:0004497 | IEA:UniProtKB-KW | F | monooxygenase activity |
| GO:0007603 | TAS:Reactome | P | phototransduction, visible light |
| GO:0042574 | NAS:BHF-UCL | P | retinal metabolic process |
| GO:0001523 | IDA:UniProtKB | P | retinoid metabolic process |
| GO:0042572 | IEA:UniProtKB-UniPathway | P | retinol metabolic process |
| GO:0035238 | NAS:BHF-UCL | P | vitamin A biosynthetic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa00830 | Retinol metabolism |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_24968 | Retinoid metabolism and transport |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR004294 | Carotenoid oxygenase |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Beta-carotene + O(2) = 2 all-trans-retinal. |
| Cofactor | Name=Fe(2+); Xref=ChEBI |
| Disease | Hypercarotenemia and vitamin A deficiency, autosomal dominant (ADHVAD) [MIM |
| Function | Symmetrically cleaves beta-carotene into two molecules of retinal. The reaction proceeds in three stages, epoxidation of the 15,15'-double bond, hydration of the double bond leading to ring opening, and oxidative cleavage of the diol formed. |
| Pathway | Cofactor metabolism; retinol metabolism. |
| Similarity | Belongs to the carotenoid oxygenase family. |
| Tissue Specificity | Highly expressed in retinal pigment epithelium. Also expressed in kidney, testis, liver, brain, small intestine and colon. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002048 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 74027270 | RefSeq | NP_059125 | 547 | beta,beta-carotene 15,15'-monooxygenase |
Identical Sequences to LMP002048 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:74027270 | EMBL | CAD33516.1 | 547 | unnamed protein product [Homo sapiens] |
| GI:74027270 | GenBank | AAG15380.1 | 547 | beta, beta-carotene 15,15'- dioxygenase [Homo sapiens] |
| GI:74027270 | GenBank | AAI26213.1 | 547 | Beta-carotene 15,15'-monooxygenase 1 [Homo sapiens] |
| GI:74027270 | GenBank | AHE02198.1 | 547 | Sequence 60552 from patent US 8586006 |
| GI:74027270 | GenBank | AIC63439.1 | 547 | BCMO1, partial [synthetic construct] |
| GI:74027270 | SwissProt | Q9HAY6.1 | 547 | RecName: Full=Beta,beta-carotene 15,15'-monooxygenase; AltName: Full=Beta-carotene dioxygenase 1; AltName: Full=Beta-carotene oxygenase 1 [Homo sapiens] |
Related Sequences to LMP002048 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:74027270 | DBBJ | BAA91776.1 | 547 | unnamed protein product [Homo sapiens] |
| GI:74027270 | EMBL | CAE89555.1 | 547 | unnamed protein product [Homo sapiens] |
| GI:74027270 | GenBank | AAI26211.1 | 547 | Beta-carotene 15,15'-monooxygenase 1 [Homo sapiens] |
| GI:74027270 | GenBank | EAW95537.1 | 547 | beta-carotene 15,15'-monooxygenase 1, isoform CRA_a [Homo sapiens] |
| GI:74027270 | GenBank | ADR83052.1 | 547 | beta-carotene 15,15'-monooxygenase 1, partial [synthetic construct] |
| GI:74027270 | GenBank | AIC56510.1 | 547 | BCMO1, partial [synthetic construct] |